Stiripentol

Generic Name
Stiripentol
Brand Names
Diacomit
Drug Type
Small Molecule
Chemical Formula
C14H18O3
CAS Number
49763-96-4
Unique Ingredient Identifier
R02XOT8V8I
Background

Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs. The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. However, its clinical efficacy as adjunctive therapy f...

Indication

In the US, stiripentol is indicated for the treatment of seizures associated with Dravet syndrome in patients taking clobazam who are 6 months of age and older and weighing 7 kg or more. There are no clinical data to support the use of stiripentol as monotherapy in Dravet syndrome.
...

Associated Conditions
Seizures, Refractory Grand mal Generalized tonic-clonic seizure
Associated Therapies
-
Clinical Trials
Related News

Stiripentol for the Treatment of Refractory Status Epilepticus

Completed
Conditions
Status Epilepticus
Interventions
Drug: Stiripentol
First Posted Date
2024-08-06
Last Posted Date
2024-08-06
Lead Sponsor
University Hospital Marburg
Target Recruit Count
25
Registration Number
NCT06540378

Study of Interest of Stiripentol and Carbamazepine in the Treatment of Patients With Pharmacoresistant Focal Epilepsies

Phase 4
Completed
Conditions
Pharmacoresistant Focal Epilepsies
Interventions
Drug: Stiripentol
First Posted Date
2022-06-15
Last Posted Date
2024-07-24
Lead Sponsor
Biocodex
Target Recruit Count
52
Registration Number
NCT05419180
Locations
🇫🇷

Centre de Référence Epilepsies Rares / Centre Investigation Clinique (CIC) - Hôpital Necker-Enfants Malades, Paris, France

Pharmacokinetic Study of Stiripentol and Its Metabolites After Multiple Dose Oral Administration in Healthy Male Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Stiripentol
First Posted Date
2019-03-07
Last Posted Date
2019-12-20
Lead Sponsor
Biocodex
Target Recruit Count
14
Registration Number
NCT03866928
Locations
🇧🇪

ATC, Liège, Belgium

Population Pharmacokinetics of Antiepileptic in Pediatrics

First Posted Date
2017-06-22
Last Posted Date
2024-10-30
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
1000
Registration Number
NCT03196466
Locations
🇫🇷

AP-HP Cochin, Paris, France

Expanded Access Use of Stiripentol in Dravet Syndrome or Sodium Channel Mutation Epileptic Encephalopathies

First Posted Date
2014-09-12
Last Posted Date
2020-02-05
Lead Sponsor
Cook Children's Health Care System
Registration Number
NCT02239276
Locations
🇺🇸

Cook Children's Medical Center, Fort Worth, Texas, United States

Treatment Plan to Provide Expanded Access to Stiripentol for Patients With Dravet Syndrome

Conditions
Dravet Syndrome
First Posted Date
2013-11-14
Last Posted Date
2019-07-11
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Registration Number
NCT01983722
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Compassionate Use of Stiripentol in Dravet Syndrome

Conditions
Dravet Syndrome
First Posted Date
2013-04-18
Last Posted Date
2019-10-04
Lead Sponsor
University of Colorado, Denver
Registration Number
NCT01835314
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Stiripentol in Dravet Syndrome

Conditions
Dravet Syndrome
First Posted Date
2012-02-15
Last Posted Date
2013-02-28
Lead Sponsor
Mayo Clinic
Registration Number
NCT01533506
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

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