MedPath

Clomifene

Generic Name
Clomifene
Brand Names
Clomid
Drug Type
Small Molecule
Chemical Formula
C26H28ClNO
CAS Number
911-45-5
Unique Ingredient Identifier
1HRS458QU2
Background

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Indication

Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.

Associated Conditions
Ovulatory Dysfunction

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH

Phase 2
Completed
Conditions
InFertility
Interventions
Drug: Pulsatile gonadotropin-releasing hormone (GnRH)
Drug: Placebo Pulsatile GnRH
First Posted Date
2006-02-27
Last Posted Date
2011-05-19
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
132
Registration Number
NCT00296465
Locations
🇺🇸

Southern Fertility Center and Clinical Research, Metairie, Louisiana, United States

Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction

First Posted Date
2005-09-21
Last Posted Date
2018-07-17
Lead Sponsor
EMD Serono
Target Recruit Count
271
Registration Number
NCT00213148
Locations
🇺🇸

Local US Medical Information, Rockland, Massachusetts, United States

Treatment of Infertility in Women With Polycystic Ovary Syndrome

Phase 3
Completed
Conditions
Polycystic Ovary Syndrome
Infertility
Pregnancy
First Posted Date
2003-09-11
Last Posted Date
2007-10-01
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Target Recruit Count
678
Registration Number
NCT00068861
Locations
🇺🇸

University of Colorado, Aurora, Colorado, United States

🇺🇸

University of Medicine and Dentistry New Jersey, Newark, New Jersey, United States

🇺🇸

University of California at San Diego, La Jolla, California, United States

and more 8 locations

Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome

Not Applicable
Completed
Conditions
Hyperinsulinism
Polycystic Ovary Syndrome
First Posted Date
2000-05-03
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
88
Registration Number
NCT00005654

Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome

Not Applicable
Completed
Conditions
Polycystic Ovary Syndrome
Hyperinsulinism
First Posted Date
2000-04-07
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
99
Registration Number
NCT00005104
Locations
🇺🇸

Louisiana State University School of Medicine, Shreveport, Louisiana, United States

🇺🇸

Washington University - St. Louis, St. Louis, Missouri, United States

🇮🇹

University Alma Mater, Bologna, Italy

and more 3 locations
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