Clomifene

Generic Name: Clomifene

Brand Names: Clomid

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₈ClNO

CAS Number: 911-45-5

Unique Ingredient Identifier: 1HRS458QU2

Background: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Indication: Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.

Associated Conditions: Ovulatory Dysfunction

Clinical Trials

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

Phase 4

Not yet recruiting

Conditions: Infertility, Female

Interventions: Drug: Clomiphene Citrate

First Posted Date: 2024-11-22

Last Posted Date: 2024-11-22

Lead Sponsor: University of Southern California

Target Recruit Count: 60

Registration Number: NCT06701071

Locations: 🇺🇸
HRC Fertility, Pasadena, California, United States

One-shot Ovarian Stimulation Protocol (One-shot)

Not Applicable

Recruiting

Conditions: Infertility, Female

Interventions: Drug: Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1
Drug: Clomiphene Citrate (CC) 100 mg/day from D1
Diagnostic Test: Monitoring cycle

First Posted Date: 2024-10-10

Last Posted Date: 2025-02-26

Lead Sponsor: Fundación Santiago Dexeus Font

Target Recruit Count: 20

Registration Number: NCT06635538

Locations: 🇪🇸
Dexeus Mujer Sabadell, Sabadell, Barcelona, Spain
🇪🇸
Dexeus Mujer Sant Cugat, Sant Cugat Del Vallès, Barcelona, Spain
🇪🇸
Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus, Barcelona, Spain

Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Phase 3

Completed

Conditions: Infertility, Male

Interventions: Drug: Placebo
Drug: Clomiphene Citrate

First Posted Date: 2024-08-21

Last Posted Date: 2024-08-23

Lead Sponsor: Shakeela Ishrat

Target Recruit Count: 50

Registration Number: NCT06564961

Locations: 🇧🇩
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Cost-effective Treatment of Unexplained Infertility

Phase 4

Completed

Conditions: Unexplained Infertility

Interventions: Drug: Clomiphene Citrate.
Drug: Sildenafil Citrate
Procedure: Intrauterine Insemination

First Posted Date: 2023-12-21

Last Posted Date: 2025-02-13

Lead Sponsor: Batterjee Medical College

Target Recruit Count: 900

Registration Number: NCT06178523

Locations: 🇸🇦
Batterjee Medical College, Jeddah, Makkah, Saudi Arabia

Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle

Not yet recruiting

Conditions: Infertility, Female
Infertility

First Posted Date: 2023-05-19

Last Posted Date: 2023-05-19

Lead Sponsor: Neil Chappell

Target Recruit Count: 10

Registration Number: NCT05866068

Locations: 🇺🇸
Womans Hospital, Baton Rouge, Louisiana, United States

Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness

Phase 2

Completed

Conditions: Infertility, Female

Interventions: Drug: Sildenafil Citrate
Drug: Clomiphene Citrate 50mg

First Posted Date: 2023-05-06

Last Posted Date: 2023-05-30

Lead Sponsor: Beni-Suef University

Target Recruit Count: 130

Registration Number: NCT05846906

Locations: 🇪🇬
Beni-suef university, Banī Suwayf, Egypt

Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility

Phase 4

Completed

Conditions: Subfertility, Female

Interventions: Drug: estrogen therapy
Drug: Sildenafil
Drug: Clomiphene Citrate 50mg

First Posted Date: 2023-03-03

Last Posted Date: 2023-04-28

Lead Sponsor: Beni-Suef University

Target Recruit Count: 148

Registration Number: NCT05753098

Locations: 🇪🇬
Beni-suef university, Banī Suwayf, Egypt

Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome

Phase 2

Completed

Conditions: Polycystic Ovary Syndrome
Infertility

Interventions: Drug: letrozole 2.5mg-7.5mg
Drug: Clomiphene Citrate 50mg-150mg

First Posted Date: 2023-01-27

Last Posted Date: 2023-01-27

Lead Sponsor: Services Institute of Medical Sciences, Pakistan

Target Recruit Count: 220

Registration Number: NCT05702957

Locations: 🇵🇰
Services Institute of Medical sciences, Lahore, Punjab, Pakistan

Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate

Phase 2

Completed

Conditions: Clomiphene Citrate
Resistant Ovary Syndrome
Polycystic Ovary Syndrome

Interventions: Dietary Supplement: Alpha lipoic acid (ALA)
Drug: Pentoxifylline (PTX)
Drug: Clomiphene Citrate

First Posted Date: 2022-02-09

Last Posted Date: 2023-07-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 120

Registration Number: NCT05231980

Locations: 🇪🇬
College of Pharmacy Teaching Hospital Ainshams University, Cairo, Egypt
🇪🇬
Medical Center of Infertility, Banī Suwayf, Egypt
🇪🇬
Misr University For Sciences and Technology Teaching Hospital, Giza, Egypt

Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation

Phase 4

Active, not recruiting

Conditions: Polycystic Ovary Syndrome
Infertility
PCOS

Interventions: Drug: Letrozole
Drug: Clomiphene Citrate

First Posted Date: 2022-01-25

Last Posted Date: 2025-04-15

Lead Sponsor: Rachel Mejia

Target Recruit Count: 190

Registration Number: NCT05206448

Locations: 🇺🇸
University of Iowa Hospitals & Clinics- West Des Moines Clinic, West Des Moines, Iowa, United States
🇺🇸
University of Wisconsin, Madison, Wisconsin, United States
🇺🇸
University of Iowa Hospitals & Clinics - Davenport Clinic, Davenport, Iowa, United States

and more 1 locations

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