Clomifene

Generic Name: Clomifene

Brand Names: Clomid

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₈ClNO

CAS Number: 911-45-5

Unique Ingredient Identifier: 1HRS458QU2

Background: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Indication: Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.

Associated Conditions: Ovulatory Dysfunction

Clinical Trials

Pharmacokinetics and Hepatic Safety of EGCG

Phase 1

Completed

Conditions: Uterine Fibroids

Interventions: Dietary Supplement: Epigallocatechin gallate (EGCG)
Drug: Clomiphene Citrate
Drug: Letrozole

First Posted Date: 2019-11-26

Last Posted Date: 2023-06-05

Lead Sponsor: Yale University

Target Recruit Count: 39

Registration Number: NCT04177693

Locations: 🇺🇸
Johns Hopkins Medicine, Baltimore, Maryland, United States

Added Value of N Acetyle Cysteine to Clomiphene Citrate in PCO

Not Applicable

Completed

Conditions: PCO

Interventions: Drug: clomiphene citrate plus metformin
Drug: Clomiphene plus metformin plus N acetyle cysteine in arm number 1
Drug: Clomiphene citrate plus metformin with chromium

First Posted Date: 2019-11-20

Last Posted Date: 2021-04-28

Lead Sponsor: Aljazeera Hospital

Target Recruit Count: 108

Registration Number: NCT04170439

Locations: 🇪🇬
Algazeerah and Kasralainy hospital, Giza, Egypt
🇪🇬
Algazeerah, Giza, Egypt

Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women

Phase 4

Completed

Conditions: PCOS
Vitamin D Deficiency

Interventions: Drug: Vit D
Drug: Metformin
Drug: Clomiphene

First Posted Date: 2019-07-08

Last Posted Date: 2019-07-08

Lead Sponsor: Ain Shams University

Target Recruit Count: 120

Registration Number: NCT04010942

Locations: 🇪🇬
Ain Shams University Maternity hospital, Cairo, Egypt

Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome

Phase 4

Conditions: Polycystic Ovary Syndrome
Ovulation Disorder
Infertility

Interventions: Drug: Gonadorelin
Drug: Clomiphene

First Posted Date: 2019-06-18

Last Posted Date: 2019-06-18

Lead Sponsor: RenJi Hospital

Target Recruit Count: 78

Registration Number: NCT03989024

Locations: 🇨🇳
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile Function

Phase 2

Completed

Conditions: Hypogonadism, Male

Interventions: Drug: Anastrozole 1mg
Drug: Clomiphene Citrate 25mg
Drug: Placebo - Cap

First Posted Date: 2019-05-01

Last Posted Date: 2019-11-18

Lead Sponsor: Albany Medical College

Target Recruit Count: 24

Registration Number: NCT03933618

The Effect Of Vitamin D Replacement Therapy On Serum Leptin And Follicular Growth Pattern In Women With Resistant Polycystic Ovary

Phase 4

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: Vitamin D
Drug: Clomiphene Citrate

First Posted Date: 2019-01-16

Last Posted Date: 2019-01-16

Lead Sponsor: Cairo University

Target Recruit Count: 100

Registration Number: NCT03806036

Locations: 🇪🇬
Kasr Alainy medical school, Cairo, Egypt

Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium

Phase 2

Completed

Conditions: Infertility, Female, Associated With Anovulation

Interventions: Drug: clomiphene citrate
Drug: Saline cervical flushing
Biological: Intrauterine Autologous platelet-rich plasma

First Posted Date: 2018-12-10

Last Posted Date: 2020-04-29

Lead Sponsor: Benha University

Target Recruit Count: 30

Registration Number: NCT03770026

Locations: 🇪🇬
Banha Faculty Hospital, Banha, Alkalubia, Egypt

Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility

Early Phase 1

Conditions: Infertility

Interventions: Drug: Placebo
Drug: Metformin
Drug: Clomiphene Citrate

First Posted Date: 2018-09-21

Last Posted Date: 2019-03-21

Lead Sponsor: Elham Raafat

Target Recruit Count: 170

Registration Number: NCT03681197

Locations: 🇪🇬
Elham Raafat Mohamed, Cairo, Egypt

Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate

Phase 2

Completed

Conditions: Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Interventions: Dietary Supplement: vitamin E
Drug: Metformin
Drug: Clomiphene Citrate

First Posted Date: 2018-09-17

Last Posted Date: 2020-07-10

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT03674385

Locations: 🇪🇬
Medical Center of Infertility, Banī Suwayf, Egypt

Study of VERU-944 to Ameliorate Hot Flashes in Men With Advanced Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer Metastatic

Interventions: Drug: Veru-944
Drug: Placebo

First Posted Date: 2018-08-24

Last Posted Date: 2021-12-03

Lead Sponsor: Veru Inc.

Target Recruit Count: 93

Registration Number: NCT03646162

Locations: 🇺🇸
Mary Crowley Cancer Research, Dallas, Texas, United States
🇺🇸
Houston Urology Partners, Houston, Texas, United States
🇺🇸
Urology of Virginia, Virginia Beach, Virginia, United States

and more 21 locations

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