Clomifene

Generic Name: Clomifene

Brand Names: Clomid

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₈ClNO

CAS Number: 911-45-5

Unique Ingredient Identifier: 1HRS458QU2

Background: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Indication: Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.

Associated Conditions: Ovulatory Dysfunction

Clinical Trials

RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders

Phase 4

Withdrawn

Conditions: Infertility

Interventions: Drug: Low-dose Clomiphene
Drug: High dose gonadotropins

First Posted Date: 2012-04-13

Last Posted Date: 2016-12-16

Lead Sponsor: Weill Medical College of Cornell University

Registration Number: NCT01577199

Metformin for the Treatment of Unexplained Oligozspermia

Phase 4

Conditions: Infertility

Interventions: Drug: Metformin / clomid / hCG
Drug: Clomiphene citrate / hCG

First Posted Date: 2012-02-08

Last Posted Date: 2015-08-07

Lead Sponsor: The Egyptian IVF-ET Center

Target Recruit Count: 600

Registration Number: NCT01529177

Locations: 🇪🇬
The Egyptian IVF-ET center, Cairo, Egypt

Clomifene Citrate as First Line Treatment in in Vitro Fertilization Cycles for Patients With Lower Ovarian Reserve

Not Applicable

Completed

Conditions: Infertility

Interventions: Drug: GnRH analog and recombinant human FSH
Drug: Clomifene Citrate

First Posted Date: 2011-07-08

Last Posted Date: 2011-07-12

Lead Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Target Recruit Count: 289

Registration Number: NCT01389713

Locations: 🇮🇹
Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to Low Dose Clomiphene Citrate in Normally Menstruating Fertile Women

Phase 1

Completed

Conditions: Infertility

First Posted Date: 2011-04-22

Last Posted Date: 2012-12-20

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 25

Registration Number: NCT01340521

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation

Not Applicable

Completed

Conditions: Mood

Interventions: Other: Placebo
Drug: Clomiphene

First Posted Date: 2011-02-07

Last Posted Date: 2016-06-28

Lead Sponsor: University of Utah

Target Recruit Count: 20

Registration Number: NCT01291056

Locations: 🇺🇸
University of Utah, Salt Lake City, Utah, United States

Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene

Phase 1

Completed

Conditions: Disorder Due Cytochrome P450 CYP2D6 Variant
Cytochrome P450 CYP3A Enzyme Deficiency
Anovulation

Interventions: Drug: Clomiphene
Drug: clomiphene and paroxetine
Drug: clomiphene and clarithromycin

First Posted Date: 2011-02-04

Last Posted Date: 2015-02-24

Lead Sponsor: Robert Bosch Gesellschaft für Medizinische Forschung mbH

Target Recruit Count: 20

Registration Number: NCT01289756

Locations: 🇩🇪
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, BW, Germany

Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination

Phase 2

Completed

Conditions: Infertility

Interventions: Drug: Clomiphene citrate regimen
Drug: Extended letrozole regimen

First Posted Date: 2010-11-02

Last Posted Date: 2011-07-12

Lead Sponsor: Cairo University

Target Recruit Count: 214

Registration Number: NCT01232075

Locations: 🇪🇬
Ahmed Elgazzar hospital, Cairo, Egypt
🇪🇬
Cairo university hospital, Cairo, Egypt

The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination

Phase 4

Completed

Conditions: Infertility

Interventions: Drug: clomiphene citrate with plasebo
Drug: clomiphene citrate with ethinyl esteradiol

First Posted Date: 2010-10-13

Last Posted Date: 2014-11-06

Lead Sponsor: Royan Institute

Target Recruit Count: 95

Registration Number: NCT01219101

Locations: 🇮🇷
Royan Institute, Tehran, Iran, Islamic Republic of

Mild Stimulation Protocol Versus Microdose Gonadotropin-releasing Hormone Agonist Flare up Protocol in Poor Responders

Phase 4

Completed

Conditions: Pregnancy

Interventions: Drug: clomiphene citrate
Drug: buserelin

First Posted Date: 2010-10-01

Last Posted Date: 2010-10-01

Lead Sponsor: Yazd Medical University

Target Recruit Count: 159

Registration Number: NCT01213147

Locations: 🇮🇷
Yazd Research and Clinical Center for Infertility, Yazd, Iran, Islamic Republic of

Minimal Stimulation or Clomiphene Citrate in Treatment of Polycystic Ovary Syndrome

Not Applicable

Completed

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: clomiphene citrate +highly purified uFSH
Drug: clomiphene citrate

First Posted Date: 2010-07-07

Last Posted Date: 2010-07-19

Lead Sponsor: Mansoura University

Target Recruit Count: 113

Registration Number: NCT01157312

Locations: 🇪🇬
Mansoura University Hospitals,OB/GYN department, Mansoura, Dakahlia Governorate, Egypt

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