Omeprazole
- Generic Name
- Omeprazole
- Brand Names
- Konvomep, Losec, Omeclamox, Omesec, Previdolrx Analgesic Pak, Prilosec, Talicia, Yosprala, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19N3O3S
- CAS Number
- 73590-58-6
- Unique Ingredient Identifier
- KG60484QX9
- Background
Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs . Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults .
- Indication
Omeprazole, according to the FDA label is a proton pump inhibitor (PPI) used for the following purposes:
• Treatment of active duodenal ulcer in adults
• Eradication of Helicobacter pylori to reduce the risk of duodenal ulcer
recurrence in adults
• Treatment of active benign gastric ulcer in adults
• Reduction of risk of upper gastrointestinal (GI) bleeding in critically ill adult patients.
• Treatment of symptomatic gastroesophageal reflux disease (GERD) in
patients 1 year of age and older
• Treatment of erosive esophagitis (EE) due to acid-mediated GERD in
patients 1 month of age and older
• Maintenance of healing of EE due to acid-mediated GERD in patients 1
year of age and older
• Pathologic hypersecretory conditions in adults
- Associated Conditions
- Ankylosing Spondylitis (AS), Duodenal Ulcer, Erosive Esophagitis, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Healing, Heartburn, Helicobacter Pylori Infection, Osteoarthritis (OA), Rheumatoid Arthritis, Upper GI Bleeding, Zollinger-Ellison Syndrome, Benign, active Gastric Ulcer, Develop NSAID-induced gastric ulcers, Hypersecretory conditions, Multiple endocrine adenomas
Antibiotic Therapy in Treating Patients With Low Grade Gastric Lymphoma
- Conditions
- Lymphoma
- First Posted Date
- 2004-08-24
- Last Posted Date
- 2012-07-02
- Target Recruit Count
- 96
- Registration Number
- NCT00003151
- Locations
- 🇬🇧
Clatterbridge Centre for Oncology NHS Trust, Merseyside, England, United Kingdom
🇬🇧Royal United Hospital, Bath, England, United Kingdom
🇬🇧Royal Free Hospital, Hampstead, London, England, United Kingdom
Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach
- Conditions
- Lymphoma
- Interventions
- First Posted Date
- 2004-06-10
- Last Posted Date
- 2018-10-24
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 5
- Registration Number
- NCT00002682
- Locations
- 🇺🇸
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
🇺🇸MD Anderson Cancer Center Orlando, Orlando, Florida, United States
Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach
- Conditions
- Gastric Cancer
- First Posted Date
- 2004-03-12
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Lymphoma Trials Office
- Target Recruit Count
- 200
- Registration Number
- NCT00003617
- Locations
- 🇬🇧
Clatterbridge Centre for Oncology NHS Trust, Merseyside, England, United Kingdom
🇬🇧Leeds Teaching Hospital Trust, Leeds, England, United Kingdom
🇬🇧Essex County Hospital, Colchester, England, United Kingdom
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
- Conditions
- Upper Gastrointestinal Bleeding
- Interventions
- First Posted Date
- 2002-09-11
- Last Posted Date
- 2019-11-25
- Lead Sponsor
- Bausch Health Americas, Inc.
- Target Recruit Count
- 354
- Registration Number
- NCT00045799
- Locations
- 🇺🇸
Verdugo Hills Hospital, Burbank, California, United States
🇺🇸Wellstar Kennestone Hospital, Marietta, Georgia, United States
🇺🇸PAB Clinical Research, Brandon, Florida, United States
The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid
- Conditions
- Zollinger Ellison SyndromeGastrinoma
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Drug Development Updates
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