Pregabalin
- Generic Name
- Pregabalin
- Brand Names
- Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C8H17NO2
- CAS Number
- 148553-50-8
- Unique Ingredient Identifier
- 55JG375S6M
- Background
Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.
- Indication
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.
- Associated Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
- Associated Therapies
- -
Pain Relief Following Arthroscopic Rotator Cuff Repair: Perioperative Pregabalin Administration Versus Interscalene Brachial Plexus Block
- Conditions
- Interventions
- First Posted Date
- 2011-05-24
- Last Posted Date
- 2011-06-07
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 56
- Registration Number
- NCT01359085
- Locations
- 🇮🇱
Tel Aviv Sourasky Medical Center, Tel Aviv, weizman 6, Israel
A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain
- Conditions
- Interventions
- First Posted Date
- 2011-04-29
- Last Posted Date
- 2013-01-08
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 193
- Registration Number
- NCT01345045
- Locations
- 🇺🇸
Site Reference ID/Investigator# 51548, Dallas, Texas, United States
🇺🇸Site Reference ID/Investigator# 51302, Omaha, Nebraska, United States
🇺🇸Site Reference ID/Investigator# 52743, Portland, Oregon, United States
Pregabalin, Celecoxib, Total Knee Arthroplasty and Intrathecal Morphine
- Conditions
- Interventions
- First Posted Date
- 2011-04-29
- Last Posted Date
- 2011-08-04
- Lead Sponsor
- Chulalongkorn University
- Target Recruit Count
- 100
- Registration Number
- NCT01344213
- Locations
- 🇹🇭
Supranee Niruthisard, Bangkok, Thailand
Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy
- Conditions
- Interventions
- First Posted Date
- 2011-04-08
- Last Posted Date
- 2021-01-28
- Target Recruit Count
- 626
- Registration Number
- NCT01332149
- Locations
- 🇨🇳
Tongren Hospital Affiliated to Capital Medical University, Beijing, China
🇨🇳Southwest hospital of the third military medical university/Department of Neurology, Chongqing, Chongqing, China
🇨🇳Department of Endocrinology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome
- First Posted Date
- 2011-04-07
- Last Posted Date
- 2014-03-03
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 18
- Registration Number
- NCT01331213
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Pregabalin and Analgesia After Laparoscopic Cholecystectomy
- First Posted Date
- 2011-03-24
- Last Posted Date
- 2013-01-29
- Lead Sponsor
- Larissa University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT01321801
- Locations
- 🇬🇷
University Hospital of Larissa, Larissa, Greece
Diabetic Peripheral Neuropathic Pain (DPNP)
- Conditions
- Interventions
- First Posted Date
- 2011-03-14
- Last Posted Date
- 2015-12-07
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 178
- Registration Number
- NCT01314222
- Locations
- 🇺🇸
Comprehensive Clinical Development, Inc., St Petersburg, Florida, United States
🇫🇷Local Institution, Nice Cedex 1, France
🇺🇸Office Of Richard S. Cherlin, Md, Los Gatos, California, United States
Primary Care Identification Of Patients With Chronic Neuropathic Low Back Pain Study
Study Of A Controlled Release Formulation Of Pregabalin In Fibromyalgia Patients
- First Posted Date
- 2011-01-07
- Last Posted Date
- 2021-01-22
- Target Recruit Count
- 441
- Registration Number
- NCT01271933
- Locations
- 🇺🇸
Broward Research Group, Pembroke Pines, Florida, United States
🇺🇸Radiant Research,, Columbus, Ohio, United States
🇺🇸Sunstone Medical Research, LLC, Medford, Oregon, United States
A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis
- First Posted Date
- 2011-01-07
- Last Posted Date
- 2020-03-20
- Lead Sponsor
- Seoul National University Boramae Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT01271660
- Locations
- 🇰🇷
Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea, Republic of
Drug Development Updates
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