Pregabalin
- Generic Name
- Pregabalin
- Brand Names
- Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C8H17NO2
- CAS Number
- 148553-50-8
- Unique Ingredient Identifier
- 55JG375S6M
- Background
Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.
- Indication
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.
- Associated Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
- Associated Therapies
- -
Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy
- First Posted Date
- 2010-01-14
- Last Posted Date
- 2021-01-28
- Target Recruit Count
- 377
- Registration Number
- NCT01049217
- Locations
- 🇵🇪
Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru
🇵🇷Ponce School of Medicine-CAIMED Center, Ponce, Puerto Rico
🇵🇪Hospital Nacional Dos de Mayo, Lima, Peru
Imipramine and Pregabalin Combination in Painful Polyneuropathy
- Conditions
- Interventions
- First Posted Date
- 2010-01-13
- Last Posted Date
- 2010-01-13
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 75
- Registration Number
- NCT01047488
- Locations
- 🇩🇰
Department of Neurology, Aalborg Hospital, Aalborg, Denmark
🇩🇰Department of Neurology, Odense University Hospital, Odense, Denmark
🇩🇰Department of Neurology, Aarhus University Hospital, Århus, Denmark
Pain in Patients With Dementia and Behavioural Disturbances
- Conditions
- Interventions
- First Posted Date
- 2009-11-30
- Last Posted Date
- 2011-08-10
- Lead Sponsor
- University of Bergen
- Target Recruit Count
- 352
- Registration Number
- NCT01021696
- Locations
- 🇳🇴
Fantoft Omsorgssenter, Bergen, Hordaland, Norway
🇳🇴Solsletten Sykehjem, Bergen, Hordaland, Norway
🇳🇴Odinsvei Nursing Home, Nesttun, Hordaland, Norway
Pregabalin In Adolescent Patients With Fibromyalgia
- First Posted Date
- 2009-11-25
- Last Posted Date
- 2021-01-28
- Target Recruit Count
- 63
- Registration Number
- NCT01020526
- Locations
- 🇮🇳
Sushrut Hospital, Research Centre & Post Graduate Institute of Orthopaedics, Nagpur, Maharashtra, India
🇺🇸University of Louisville, Louisville, Kentucky, United States
🇮🇳Krishna Institute of Medical Sciences Ltd, Secunderabad, Andhra Pradesh, India
The Effect of Perioperative Pregabalin on the Incidence of Chronic Post-thoracotomy Pain Syndrome
- First Posted Date
- 2009-10-21
- Last Posted Date
- 2012-04-11
- Lead Sponsor
- Queen's University
- Registration Number
- NCT00998816
- Locations
- 🇨🇦
Dr. Jorge E Zamora, Kingston, Ontario, Canada
A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
- First Posted Date
- 2009-10-14
- Last Posted Date
- 2019-06-18
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 15
- Registration Number
- NCT00994786
- Locations
- 🇨🇦
MacAnxiety Research Centre, Hamilton, Ontario, Canada
Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance
- Conditions
- Interventions
- First Posted Date
- 2009-10-07
- Last Posted Date
- 2021-02-15
- Target Recruit Count
- 85
- Registration Number
- NCT00991276
- Locations
- 🇺🇸
Pfizer Investigational Site, Dallas, Texas, United States
Study to Determine if a Reduction in Pain Can be Measured in Spinal Cord Injured Patients Using a New Study Design
- Conditions
- Interventions
- First Posted Date
- 2009-09-16
- Last Posted Date
- 2021-01-25
- Target Recruit Count
- 15
- Registration Number
- NCT00978341
- Locations
- 🇦🇺
Pfizer Investigational Site, Heidelberg, Victoria, Australia
A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome
- First Posted Date
- 2009-09-15
- Last Posted Date
- 2016-10-28
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 85
- Registration Number
- NCT00977197
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
🇺🇸Mayo Clinic Health System - Franciscan Healthcare in La Crosse, La Crosse, Wisconsin, United States
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.
- First Posted Date
- 2009-08-27
- Last Posted Date
- 2012-04-12
- Target Recruit Count
- 110
- Registration Number
- NCT00967135
- Locations
- 🇨🇦
Centre Hospitalier de l'Université de Montréal (Hôpital Notre-Dame), Montreal, Quebec, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.