Pregabalin

Generic Name
Pregabalin
Brand Names
Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
Drug Type
Small Molecule
Chemical Formula
C8H17NO2
CAS Number
148553-50-8
Unique Ingredient Identifier
55JG375S6M
Background

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by bind...

Indication

Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions
Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
Associated Therapies
-
Clinical Trials
Related News

The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting

First Posted Date
2008-02-26
Last Posted Date
2011-03-16
Lead Sponsor
University of Manitoba
Target Recruit Count
40
Registration Number
NCT00623285
Locations
🇨🇦

St. Boniface General Hospital, Winnipeg, Manitoba, Canada

A Methodology Study Of Brain Imaging Of Pain-Killers In Post-Traumatic Neuropathic Pain Patients

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: Tramadol SR
Drug: Pregabalin
First Posted Date
2008-02-07
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
18
Registration Number
NCT00610155
Locations
🇬🇧

Pfizer Investigational Site, Solihull, West Midlands, United Kingdom

Bunionectomy Study (0000-063)

Phase 1
Completed
Conditions
Acute Pain
Interventions
Drug: pregabalin
Drug: naproxen sodium
First Posted Date
2008-01-28
Last Posted Date
2015-04-10
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
100
Registration Number
NCT00601458

A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia

First Posted Date
2008-01-24
Last Posted Date
2021-08-05
Lead Sponsor
Pfizer
Target Recruit Count
72
Registration Number
NCT00599638
Locations
🇺🇸

Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, United States

🇺🇸

Arthritis Associates of South Florida, Delray Beach, Florida, United States

🇺🇸

Delray Research Associates, Delray Beach, Florida, United States

and more 36 locations

Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures

Phase 3
Completed
Conditions
Epilepsy
Interventions
Drug: pregabalin
First Posted Date
2008-01-17
Last Posted Date
2021-01-26
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
75
Registration Number
NCT00596466
Locations
🇺🇦

Pfizer Investigational Site, Odessa, Ukraine

Pregabalin (Lyrica) for the Treatment of Essential Tremor

Phase 4
Completed
Conditions
Essential Tremor
Interventions
Drug: Placebo
Drug: Pregabalin
First Posted Date
2008-01-02
Last Posted Date
2012-06-18
Lead Sponsor
University of South Florida
Target Recruit Count
29
Registration Number
NCT00584376
Locations
🇺🇸

Emory Univ. School of Medicine, Atlanta, Georgia, United States

🇺🇸

Medical College of Georgia, Augusta, Georgia, United States

🇺🇸

Vanderbilt, Nashville, Tennessee, United States

and more 5 locations

Role of Pregabalin in Treatment of Post-Op Pain in Fracture Patients

Early Phase 1
Completed
Conditions
Post-operative Pain
Interventions
Drug: Placebo
Drug: Pregabalin
First Posted Date
2008-01-02
Last Posted Date
2014-01-07
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
86
Registration Number
NCT00583869
Locations
🇺🇸

The University of Alabama at Birmingham, Birmingham, Alabama, United States

A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy

Phase 4
Completed
Conditions
Diabetic Neuropathy
Interventions
Drug: Placebo
Drug: Pregabalin
First Posted Date
2007-12-14
Last Posted Date
2014-07-21
Lead Sponsor
Duke University
Target Recruit Count
40
Registration Number
NCT00573261
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA

Phase 2
Completed
Conditions
CRPS
Interventions
Drug: Placebo
Drug: pregabalin
First Posted Date
2007-11-15
Last Posted Date
2016-05-26
Lead Sponsor
Rush University Medical Center
Target Recruit Count
240
Registration Number
NCT00558753

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy

Phase 3
Completed
Conditions
Diabetic Neuropathy, Painful
Interventions
Drug: pregabalin
First Posted Date
2007-11-04
Last Posted Date
2021-01-25
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
123
Registration Number
NCT00553280
Locations
🇯🇵

Pfizer Investigational Site, Tokushima, Japan

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy