Pregabalin

Generic Name: Pregabalin

Brand Names: Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₇NO_₂

CAS Number: 148553-50-8

Unique Ingredient Identifier: 55JG375S6M

Background: Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by bind...

Indication: Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions: Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia

Associated Therapies: -

Clinical Trials

Pregabalin Trial for the Treatment of Alcohol Use Disorder

Phase 2

Suspended

Conditions: Alcohol Use Disorder

Interventions: Other: Placebo
Drug: Pregabalin

First Posted Date: 2020-03-26

Last Posted Date: 2023-09-05

Lead Sponsor: New York State Psychiatric Institute

Target Recruit Count: 50

Registration Number: NCT04322305

Locations: 🇺🇸
Nyspi-Stars, New York, New York, United States

Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life

Phase 4

Terminated

Conditions: Painful Diabetic Peripheral Neuropathy

Interventions: Drug: Pregabalin
Drug: Duloxetine

First Posted Date: 2020-01-29

Last Posted Date: 2022-04-07

Lead Sponsor: KRKA

Target Recruit Count: 254

Registration Number: NCT04246619

Locations: 🇸🇮
Zdravstveni dom Koper, Koper, Slovenia
🇭🇷
Opća bolnica Karlovac, Karlovac, Croatia
🇭🇷
Klinička bolnica Sveti Duh, Zagreb, Croatia

and more 10 locations

Pregabalin for the Prevention of Chemotherapy Induced Nausea and Vomiting

Phase 2

Conditions: Nausea

Interventions: Drug: Placebo
Drug: Pregabalin

First Posted Date: 2019-11-29

Last Posted Date: 2019-11-29

Lead Sponsor: Faculdade de Medicina do ABC

Target Recruit Count: 82

Registration Number: NCT04181346

Locations: 🇧🇷
IBCC Oncologia, São Paulo, SP, Brazil

A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery

Phase 4

Completed

Conditions: Opioid Use

Interventions: Drug: Celecoxib
Drug: Percocet
Drug: Acetaminophen
Drug: Pregabalin
Drug: Oxycodone

First Posted Date: 2019-07-11

Last Posted Date: 2024-07-08

Lead Sponsor: University of Utah

Target Recruit Count: 100

Registration Number: NCT04015908

Locations: 🇺🇸
University of Utah, Salt Lake City, Utah, United States

Pregabalin Treatment for RDEB Pain and Itch

Phase 3

Completed

Conditions: Epidermolysis Bullosa
Pain, Neuropathic
Itch

Interventions: Drug: Pregabalin

First Posted Date: 2019-04-25

Last Posted Date: 2024-02-12

Lead Sponsor: The Hospital for Sick Children

Target Recruit Count: 1

Registration Number: NCT03928093

Locations: 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada

Efficacy of Pregabalin for the Treatment of Acute Herpetic Neuralgia

Phase 4

Completed

Conditions: Herpes Zoster

Interventions: Drug: Placebo
Drug: Pregabalin

First Posted Date: 2019-01-18

Last Posted Date: 2020-10-14

Lead Sponsor: B.P. Koirala Institute of Health Sciences

Target Recruit Count: 82

Registration Number: NCT03809702

Locations: 🇳🇵
B P Koirala Institute of Health Sciences, Dharān Bāzār, Province 1, Nepal

Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery

Phase 3

Completed

Conditions: Breast Cancer Patient

Interventions: Drug: Capsaicin
Drug: Pregabalin

First Posted Date: 2019-01-07

Last Posted Date: 2023-08-01

Lead Sponsor: Institut Cancerologie de l'Ouest

Target Recruit Count: 140

Registration Number: NCT03794388

Locations: 🇫🇷
Centre Leon Berard, Lyon, France
🇫🇷
Ch Valenciennes, Valenciennes, France
🇫🇷
Institut de Cancerologie de L'Ouest, Angers, France

and more 8 locations

Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI

Phase 4

Conditions: Spinal Cord Injuries
Central Pain Syndrome

Interventions: Drug: Placebo Oral Tablet
Drug: Pregabalin

First Posted Date: 2018-11-20

Last Posted Date: 2018-11-20

Lead Sponsor: Sheba Medical Center

Target Recruit Count: 50

Registration Number: NCT03748290

Locations: 🇮🇱
Sheba Medical Center rehabilitaion facility, Ramat Gan, Israel

Pharmacokinetics of Two Formulation of Pregabalin

Phase 4

Completed

Conditions: Diabetic Peripheral Neuropathy
Fibromyalgia
Partial Seizure Disorder

Interventions: Drug: Pregabalin

First Posted Date: 2018-10-19

Last Posted Date: 2019-01-28

Lead Sponsor: Yung Shin Pharm. Ind. Co., Ltd.

Target Recruit Count: 28

Registration Number: NCT03712475

Locations: 🇨🇳
Taichung Veterans General Hospital, Taichung, Taiwan

Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy

Phase 2

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Placebo oral capsule
Drug: Ketorolac
Drug: Saline
Drug: Pregabalin

First Posted Date: 2018-09-13

Last Posted Date: 2019-08-15

Lead Sponsor: University of Utah

Target Recruit Count: 64

Registration Number: NCT03669081

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