Pregabalin

Generic Name
Pregabalin
Brand Names
Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
Drug Type
Small Molecule
Chemical Formula
C8H17NO2
CAS Number
148553-50-8
Unique Ingredient Identifier
55JG375S6M
Background

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by bind...

Indication

Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions
Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
Associated Therapies
-
Clinical Trials
Related News

Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery

Phase 3
Active, not recruiting
Conditions
Persistent Postoperative Pain
Interventions
Drug: Placebos
Drug: Pregabalin
First Posted Date
2017-07-13
Last Posted Date
2024-06-13
Lead Sponsor
Benno Rehberg-Klug
Target Recruit Count
126
Registration Number
NCT03216187
Locations
🇨🇭

Brustzentrum Bern, Bern, Switzerland

🇨🇭

Clinique de Genolier, Genolier, Switzerland

🇨🇭

Clinique des Grangettes, Geneva, Switzerland

and more 3 locations

Does Perioperative Pregabalin Reduce Postoperative Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery Under Spinal Anesthesia?

First Posted Date
2017-07-07
Last Posted Date
2019-02-20
Lead Sponsor
Yonsei University
Target Recruit Count
96
Registration Number
NCT03211728
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of

Pregabalin Treatment and Prevention Post-herpetic Neuralgia

First Posted Date
2017-06-14
Last Posted Date
2017-06-14
Lead Sponsor
Second Affiliated Hospital of Guangzhou Medical University
Target Recruit Count
342
Registration Number
NCT03186443
Locations
🇨🇳

National drug clinical trial fundation, Guangzhou, Guangdong, China

Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica

Phase 4
Completed
Conditions
Healthy
Interventions
Other: Placebo
Drug: Pregabalin
Drug: Gabapentin
First Posted Date
2017-06-07
Last Posted Date
2020-06-01
Lead Sponsor
Depomed
Target Recruit Count
32
Registration Number
NCT03179345

Evaluating the Role of Pregabalin in Reducing Opioid Requirement in Spinal Fusion Surgeries of Two or More Vertebrae

Phase 3
Terminated
Conditions
Spinal Fusion
Interventions
Other: placebo
Drug: Pregabalin
First Posted Date
2017-01-25
Last Posted Date
2019-08-20
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
3
Registration Number
NCT03031340
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Pregabalin for Opiate Withdrawal Syndrome

First Posted Date
2017-01-11
Last Posted Date
2020-04-07
Lead Sponsor
St. Petersburg Bekhterev Research Psychoneurological Institute
Target Recruit Count
100
Registration Number
NCT03017430
Locations
🇷🇺

St.-Petersburg Bekhterev Reserach Psychoneurological Institute, St.-Petersburg, Russian Federation

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

First Posted Date
2016-11-03
Last Posted Date
2017-09-14
Lead Sponsor
National University Hospital, Singapore
Target Recruit Count
116
Registration Number
NCT02954484

The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy

First Posted Date
2016-10-07
Last Posted Date
2016-10-07
Lead Sponsor
Eastern Virginia Medical School
Target Recruit Count
44
Registration Number
NCT02927951
Locations
🇺🇸

Eastern Virgnia Medical School, Strelitz Diabetes Center, Norfolk, Virginia, United States

🇺🇸

Strelitz Diabetes Center, Norfolk, Virginia, United States

Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.

Phase 2
Terminated
Conditions
Earache
Interventions
Drug: Pregabalin
Drug: Placebo
First Posted Date
2016-10-05
Last Posted Date
2019-10-14
Lead Sponsor
University Hospital, Lille
Target Recruit Count
42
Registration Number
NCT02924675
Locations
🇫🇷

CHRU, Hôpital Claude Huriez, Lille, France

Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement

First Posted Date
2016-08-15
Last Posted Date
2018-04-03
Lead Sponsor
Christophe Aveline, MD
Target Recruit Count
70
Registration Number
NCT02866396
Locations
🇫🇷

Christophe Aveline, MD, Cesson Sevigne, France

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