Permethrin

Generic Name: Permethrin

Brand Names: Elimite, Nix Cream Rinse

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₀Cl_₂O_₃

CAS Number: 52645-53-1

Unique Ingredient Identifier: 509F88P9SZ

Background: A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Indication: For the treatment of infestation with Sarcoptes scabiei (scabies).

Associated Conditions: Head Lice Infestation, Norwegian scabies, Scabies, Lice of the pubic area

Clinical Trials

A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of Permethrin Foam, 5% and Permethrin Foam, 4% for the Treatment of Scabies

Phase 2

Completed

Conditions: Scabies

Interventions: Drug: Permethrin Foam 4%
Drug: Permethrin Foam 5%
Drug: Vehicle Foam

First Posted Date: 2014-03-24

Last Posted Date: 2023-04-26

Lead Sponsor: Mylan Inc.

Target Recruit Count: 130

Registration Number: NCT02094716

Locations: 🇵🇷
Clinical Research Site, Ponce, Puerto Rico

Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin

Not Applicable

Completed

Conditions: Pediculosis Capitis

Interventions: Drug: 1% permethrin creme rinse
Drug: Licefreee Spray

First Posted Date: 2012-01-23

Last Posted Date: 2015-01-01

Lead Sponsor: South Florida Family Health and Research Centers

Target Recruit Count: 42

Registration Number: NCT01514513

Locations: 🇺🇸
Lice Source Services Inc., Plantation, Florida, United States

Effectiveness of Permethrin Impregnated Underwear in Preventing Louse Proliferation in Infected Homeless

Not Applicable

Terminated

Conditions: Body's Louses

Interventions: Drug: no Permethrin impregnated
Drug: Permethrin impregnated

First Posted Date: 2011-02-01

Last Posted Date: 2014-08-29

Lead Sponsor: Assistance Publique Hopitaux De Marseille

Target Recruit Count: 125

Registration Number: NCT01287663

Locations: 🇫🇷
Assistance Publique Hopitaux de Marseille, Marseille, France

Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice

Phase 3

Completed

Conditions: Pediculosis

Interventions: Drug: Malathion gel 0.5%
Drug: Permethrin 1% rinse (Nix Crème)

First Posted Date: 2009-08-21

Last Posted Date: 2014-06-13

Lead Sponsor: Taro Pharmaceuticals USA

Target Recruit Count: 403

Registration Number: NCT00963508

Locations: 🇺🇸
Investigator Site, San Antonio, Texas, United States

Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice

Phase 3

Completed

Conditions: Pediculosis

Interventions: Drug: Permethrin 1% rinse
Drug: Malathion gel 0.5%

First Posted Date: 2009-06-25

Last Posted Date: 2014-08-04

Lead Sponsor: Taro Pharmaceuticals USA

Target Recruit Count: 254

Registration Number: NCT00927472

Locations: 🇺🇸
Investigator Site, Jonesboro, Arkansas, United States

A Safety and Efficacy Pilot Study Comparing NatrOVA Creme Rinse 1% and NIX Creme Rinse

Phase 2

Completed

Conditions: Pediculosis Capitis
Head Lice

Interventions: Drug: NatrOVA Creme Rinse - 1%
Drug: NIX Creme Rinse - 1% permethrin

First Posted Date: 2009-03-09

Last Posted Date: 2009-03-09

Lead Sponsor: ParaPRO LLC

Target Recruit Count: 24

Registration Number: NCT00857935

Locations: 🇺🇸
Concentrics Research, Indianapolis, Indiana, United States

Veron Scabies Education and Eradication Program

Not Applicable

Completed

Conditions: Scabies

Interventions: Drug: Permethrin 5% lotion
Drug: Ivermectin

First Posted Date: 2008-01-29

Last Posted Date: 2019-07-22

Lead Sponsor: Edward Via Virginia College of Osteopathic Medicine

Target Recruit Count: 1057

Registration Number: NCT00604084

Locations: 🇩🇴
Barrio Nuevo, Veron, La Altagracia, Dominican Republic

Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice

Phase 3

Completed

Conditions: Pediculus Capitis Infestation

Interventions: Drug: Spinosad
Drug: Permethrin 1%

First Posted Date: 2007-10-17

Last Posted Date: 2012-10-11

Lead Sponsor: ParaPRO LLC

Target Recruit Count: 480

Registration Number: NCT00545168

Locations: 🇺🇸
Alegent Health Clinic, Council Bluffs, Iowa, United States
🇺🇸
Advanced Dermatology and Cosmetic Surgery, Ormond Beach, Florida, United States
🇺🇸
Wee Care Pediatrics, Layton, Utah, United States

and more 3 locations

Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice

Phase 3

Completed

Conditions: Pediculosis

Interventions: Drug: Permethrin 1%
Drug: Spinosad

First Posted Date: 2007-10-17

Last Posted Date: 2012-10-11

Lead Sponsor: ParaPRO LLC

Target Recruit Count: 558

Registration Number: NCT00545753

Locations: 🇺🇸
Burke Pharmaceutical Research, Hot Springs, Arkansas, United States
🇺🇸
Hill Top Research, Miamiville, Ohio, United States
🇺🇸
Impact Clinical Trials, Beverly Hills, California, United States

and more 2 locations

Comparison of the Efficacy and Safety of Ivermectin to Permethrin

Phase 2

Completed

Conditions: Scabies

First Posted Date: 2005-12-06

Last Posted Date: 2007-12-28

Lead Sponsor: University Ghent

Target Recruit Count: 160

Registration Number: NCT00262418

Locations: 🇧🇪
University Hospital Ghent, Ghent, Belgium

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