Propranolol

Generic Name: Propranolol

Brand Names: Hemangeol, Hemangiol, Inderal, Innopran

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₁NO_₂

CAS Number: 525-66-6

Unique Ingredient Identifier: 9Y8NXQ24VQ

Background: Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication: Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions: Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)

Associated Therapies: -

Clinical Trials

Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

Phase 2

Withdrawn

Conditions: Dysfunctional Labor

Interventions: Drug: Propranolol
Other: IV Placebo

First Posted Date: 2006-04-19

Last Posted Date: 2019-02-27

Lead Sponsor: University of California, Irvine

Registration Number: NCT00315913

Locations: 🇺🇸
Long Beach Memorial Medical Center, Long Beach, California, United States

Treatment of Orthostatic Intolerance

First Posted Date: 2005-12-06

Last Posted Date: 2024-10-02

Lead Sponsor: Satish R. Raj

Target Recruit Count: 150

Registration Number: NCT00262470

Locations: 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States

Analysis of Atropine and Propranolol Induced Changes

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Atropine
Drug: Normal Saline
Drug: Propranolol

First Posted Date: 2005-11-10

Last Posted Date: 2012-08-06

Lead Sponsor: National Institute on Aging (NIA)

Target Recruit Count: 24

Registration Number: NCT00251602

Locations: 🇺🇸
National Institute on Aging, Harbor Hospital, Baltimore, Maryland, United States

Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2

Phase 2

Completed

Conditions: Cocaine-Related Disorders

Interventions: Drug: Propranolol
Drug: Placebo
Drug: Amantadine

First Posted Date: 2005-09-12

Last Posted Date: 2017-01-12

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 199

Registration Number: NCT00158132

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

Effect of Propranolol on Preventing Posttraumatic Stress Disorder

Phase 4

Completed

Conditions: Post-Traumatic Stress Disorder

Interventions: Drug: Propranolol
Drug: Placebo

First Posted Date: 2005-09-12

Last Posted Date: 2017-04-10

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 43

Registration Number: NCT00158262

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States