Propranolol
- Generic Name
- Propranolol
- Brand Names
- Hemangeol, Hemangiol, Inderal, Innopran
- Drug Type
- Small Molecule
- Chemical Formula
- C16H21NO2
- CAS Number
- 525-66-6
- Unique Ingredient Identifier
- 9Y8NXQ24VQ
- Background
Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.
Propranolol was granted FDA approval on 13 November 1967.
- Indication
Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.
- Associated Conditions
- Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)
- Associated Therapies
- -
Systemic Propranolol for the Treatment of Paediatric Patients With Infantile Hemangiomas
- First Posted Date
- 2020-12-03
- Last Posted Date
- 2020-12-03
- Lead Sponsor
- Qilu Hospital of Shandong University
- Target Recruit Count
- 128
- Registration Number
- NCT04651049
Pre-surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60%
- Conditions
- Interventions
- First Posted Date
- 2020-09-04
- Last Posted Date
- 2020-11-02
- Lead Sponsor
- Centro Ortopedico y Quirurgico del Pie
- Target Recruit Count
- 24
- Registration Number
- NCT04538365
- Locations
- 🇪🇸
Facultad de Enfermeria, Fisioterapia y Podologia, Madrid, Spain
Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas
- Conditions
- Interventions
- First Posted Date
- 2020-09-01
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Ahmed mohamed fathy ismail
- Target Recruit Count
- 128
- Registration Number
- NCT04533841
- Locations
- 🇪🇬
Ahmed mohamed fathy ismail, Zagazig, El Sharquia, Egypt
Propranolol in Angiosarcoma
- First Posted Date
- 2020-08-19
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- The Netherlands Cancer Institute
- Target Recruit Count
- 14
- Registration Number
- NCT04518124
- Locations
- 🇳🇱
Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, Netherlands
Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status
- Conditions
- Interventions
- First Posted Date
- 2020-08-11
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 771
- Registration Number
- NCT04508244
- Locations
- 🇶🇦
Hamad General Hospital, Doha, Qatar
Primary Prophylaxis for Variceal Bleed in Biliary Atresia
- Conditions
- Interventions
- First Posted Date
- 2020-07-31
- Last Posted Date
- 2021-03-18
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 92
- Registration Number
- NCT04494763
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH)
- Conditions
- Interventions
- First Posted Date
- 2020-05-29
- Last Posted Date
- 2020-05-29
- Lead Sponsor
- Shanghai Children's Medical Center
- Target Recruit Count
- 36
- Registration Number
- NCT04406870
- Locations
- 🇨🇳
Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China
Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.
- Conditions
- Interventions
- First Posted Date
- 2019-12-23
- Last Posted Date
- 2024-03-20
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 140
- Registration Number
- NCT04208776
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
Efficacy of Ivabradine Versus Propranolol Premedication During Hypotensive Anesthesia in Endoscopic Sinus Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-12-23
- Last Posted Date
- 2019-12-23
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 50
- Registration Number
- NCT04208594
- Locations
- 🇪🇬
Alexandria university, Alexandria, Egypt
Impact of Nonselective Beta-blocker on Acute Kidney Injury in Cirrhotic Patients With Esophageal Varices
- First Posted Date
- 2019-08-30
- Last Posted Date
- 2019-09-20
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 170
- Registration Number
- NCT04074473
- Locations
- 🇨🇳
Taipei Veterans General Hospital, Taipei, Taiwan
Drug Development Updates
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