Propranolol

Generic Name
Propranolol
Brand Names
Hemangeol, Hemangiol, Inderal, Innopran
Drug Type
Small Molecule
Chemical Formula
C16H21NO2
CAS Number
525-66-6
Unique Ingredient Identifier
9Y8NXQ24VQ
Background

Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication

Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions
Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)
Associated Therapies
-
Clinical Trials
Related News

Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Phase 4
Completed
Conditions
Hyperthyroidism
Interventions
Drug: Propanolol
First Posted Date
2018-01-08
Last Posted Date
2018-01-08
Lead Sponsor
Yaounde Central Hospital
Target Recruit Count
10
Registration Number
NCT03393728

Oral Propranolol for Reducing Pediatric Dental Patients Anxiety

Not Applicable
Completed
Conditions
Extrusion of Tooth
Interventions
Drug: Midazolam
Drug: Propranolol
First Posted Date
2018-01-03
Last Posted Date
2021-03-24
Lead Sponsor
Damascus University
Target Recruit Count
60
Registration Number
NCT03388957
Locations
🇸🇾

Department of Peadodontics, University of Damascus Dental School, Damascus, Syrian Arab Republic

Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy

Phase 4
Completed
Conditions
Hyperthyroidism
Interventions
Drug: Propranolol
First Posted Date
2017-12-20
Last Posted Date
2020-02-13
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
19
Registration Number
NCT03379181
Locations
🇨🇭

University Hospital Basel, Department of Endocrinology, Basel, BS, Switzerland

Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol

First Posted Date
2017-12-06
Last Posted Date
2018-08-28
Lead Sponsor
Mark Ware
Target Recruit Count
10
Registration Number
NCT03364075
Locations
🇨🇦

Centre for Innovative Medicine - McGill University Health Centre, Montréal, Quebec, Canada

Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients

First Posted Date
2017-11-21
Last Posted Date
2020-01-07
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
240
Registration Number
NCT03348683
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Study of Propranolol Plus Sunitinib in First-line Treatment of Metastatic Renal Cell Carcinoma

Phase 2
Withdrawn
Conditions
Renal Cell Carcinoma
Interventions
Drug: Propranolol
Drug: Sunitinib
First Posted Date
2017-10-27
Last Posted Date
2019-01-09
Lead Sponsor
Military Institute od Medicine National Research Institute
Registration Number
NCT03323710
Locations
🇵🇱

Military Institute of Medicine, Warsaw, Mazowieckie, Poland

Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity

Phase 4
Completed
Conditions
Cigarette Smoking
Interventions
Drug: Placebo
Drug: Propranolol
First Posted Date
2017-10-16
Last Posted Date
2020-08-13
Lead Sponsor
Duke University
Target Recruit Count
44
Registration Number
NCT03309943
Locations
🇺🇸

Duke University School of Medicine, Durham, North Carolina, United States

A Study of Lasmiditan and Propranolol in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Lasmiditan
Drug: Propranolol
First Posted Date
2017-09-01
Last Posted Date
2019-12-16
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
44
Registration Number
NCT03270644
Locations
🇺🇸

Covance Daytona Beach, Daytona Beach, Florida, United States

Nabilone in Cannabis Users With PTSD

First Posted Date
2017-08-16
Last Posted Date
2022-07-15
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
4
Registration Number
NCT03251326
Locations
🇺🇸

New York State Psychiatric Institute, New York, New York, United States

Clinical Research on Teratment of Gastrointestinal Cancer in the Preoperative by Propranolol

Early Phase 1
Conditions
Gastrointestinal Cancer
Interventions
Drug: Propranolol
First Posted Date
2017-08-10
Last Posted Date
2018-04-09
Lead Sponsor
Central South University
Target Recruit Count
80
Registration Number
NCT03245554
Locations
🇨🇳

Institute of Clinical Pharmacology, Changsha, Hunan, China

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