DeepMed Research

Acetazolamide

Generic Name: Acetazolamide

Drug Type: Small Molecule

Chemical Formula: C_₄H_₆N_₄O_₃S_₂

CAS Number: 59-66-5

Unique Ingredient Identifier: O3FX965V0I

Background: One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions: Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication

Associated Therapies: Urine alkalinization therapy

Clinical Trials

Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia

Phase 4

Completed

Conditions: Hyperalgesia
Opioid-Related Disorders

Interventions: Drug: Placebo Oral Tablet
Drug: Acetazolamide

First Posted Date: 2016-12-14

Last Posted Date: 2018-12-31

Lead Sponsor: University of Chile

Target Recruit Count: 50

Registration Number: NCT02992938

Locations: 🇨🇱
Faculty of Medicine, University of Chile, Santiago, Metropolitana, Chile

Controlled Hyperventilation as Prophylaxis for Acute Mountain Sickness

Not Applicable

Conditions: Altitude Sickness

Interventions: Behavioral: Voluntary ventilatory response
Drug: Acetazolamide

First Posted Date: 2016-11-23

Last Posted Date: 2016-11-23

Lead Sponsor: Hospital del Trabajador de Santiago

Target Recruit Count: 30

Registration Number: NCT02972411

Locations: 🇨🇱
110 Sports and health center, Santiago, Chile

Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Phase 2

Terminated

Conditions: Neurocysticercosis

Interventions: Drug: Dexamethasone
Drug: Acetazolamide

First Posted Date: 2016-10-26

Last Posted Date: 2025-04-01

Lead Sponsor: Universidad Peruana Cayetano Heredia

Target Recruit Count: 4

Registration Number: NCT02945527

Locations: 🇵🇪
Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru

Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome

Phase 2

Terminated

Conditions: Landau-Kleffner Syndrome
Status Epilepticus, Electrographic

Interventions: Drug: Diazepam
Drug: Acetazolamide

First Posted Date: 2016-09-16

Last Posted Date: 2020-06-11

Lead Sponsor: Mayo Clinic

Target Recruit Count: 3

Registration Number: NCT02904265

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Acetazolamide to Prevent Post Operative CSF Leak

Phase 2

Withdrawn

Conditions: Cerebrospinal Fluid Leak

Interventions: Drug: Acetazolamide

First Posted Date: 2016-09-15

Last Posted Date: 2020-04-21

Lead Sponsor: University of Miami

Registration Number: NCT02902133

Cerebrovascular Reserve Measurements in Sickle Cell Disease

Conditions: Sickle Cell Disease

Interventions: Drug: Acetazolamide

First Posted Date: 2016-07-06

Last Posted Date: 2016-07-06

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 60

Registration Number: NCT02824406

Locations: 🇳🇱
Academic Medical Center, Amsterdam, Netherlands

Evaluation of the Effect of Acetazolamide, Mannitol and N-acetylcysteine on Cisplatin-Induced Nephrotoxicity

Phase 2

Completed

Conditions: Cisplatin Nephrotoxicity

Interventions: Drug: Acetazolamide
Drug: Mannitol
Drug: Acetylcysteine
Drug: saline
Drug: Cisplatin

First Posted Date: 2016-05-04

Last Posted Date: 2017-01-24

Lead Sponsor: Ain Shams University

Target Recruit Count: 52

Registration Number: NCT02760901

AZ, MZ, and the Pulmonary System Response to Hypoxia

Phase 4

Completed

Conditions: Altitude Sickness
Hypertension, Pulmonary

Interventions: Drug: Placebo
Drug: Acetazolamide
Drug: Methazolamide

First Posted Date: 2016-05-03

Last Posted Date: 2016-10-19

Lead Sponsor: University of British Columbia

Target Recruit Count: 14

Registration Number: NCT02760121

Locations: 🇨🇦
University of British Columbia, Kelowna, British Columbia, Canada

Muscle Fatigue and Carbonic Anhydrase Inhibitors

Phase 4

Completed

Conditions: Hypoxia

Interventions: Other: Placebo
Drug: Acetazolamide
Drug: Methazolamide

First Posted Date: 2016-05-02

Last Posted Date: 2018-09-25

Lead Sponsor: University of British Columbia

Target Recruit Count: 13

Registration Number: NCT02758470

Locations: 🇨🇦
University of British Columbia, Kelowna, British Columbia, Canada

Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

Phase 2

Completed

Conditions: Hypertension, Pulmonary

Interventions: Drug: Placebo
Drug: Acetazolamide

First Posted Date: 2016-04-28

Last Posted Date: 2019-08-13

Lead Sponsor: University of Zurich

Target Recruit Count: 33

Registration Number: NCT02755259

Locations: 🇨🇭
University Hospital Zurich, Zurich, Switzerland

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