Acetazolamide

Generic Name: Acetazolamide

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₄H_₆N_₄O_₃S_₂

CAS Number: 59-66-5

Unique Ingredient Identifier: O3FX965V0I

Background: One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions: Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication

Associated Therapies: Urine alkalinization therapy

Clinical Trials

A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent

Phase 4

Completed

Conditions: Acute Mountain Sickness

Interventions: Drug: Placebo
Drug: Acetazolamide

First Posted Date: 2011-08-16

Last Posted Date: 2013-06-24

Lead Sponsor: Oxford University Clinical Research Unit, Vietnam

Target Recruit Count: 380

Registration Number: NCT01418157

Locations: 🇳🇵
Oxford University Clinical Research Unit Nepal, Kathmandu, Nepal

Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients

Not Applicable

Completed

Conditions: Heart Failures

Interventions: Drug: Placebo
Drug: Acetazolamide

First Posted Date: 2011-06-22

Last Posted Date: 2018-06-13

Lead Sponsor: David Andrew Wellman

Target Recruit Count: 29

Registration Number: NCT01377987

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Intracranial Pressure in Experimental Models of Headache

Not Applicable

Completed

Conditions: High Altitude Headache

Interventions: Drug: Lactose monohydrate
Drug: Acetazolamide

First Posted Date: 2011-02-02

Last Posted Date: 2012-02-07

Lead Sponsor: Bangor University

Target Recruit Count: 23

Registration Number: NCT01288781

Locations: 🇬🇧
School of Sport, Health and Exercise Sciences, Bangor University, Bangor, Gwynedd, United Kingdom

Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru

Phase 1

Completed

Conditions: Mountain Sickness
Erythrocytosis

Interventions: Drug: Placebo pills
Drug: N-acetylcysteine
Drug: Acetazolamide

First Posted Date: 2010-08-23

Last Posted Date: 2015-05-15

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 85

Registration Number: NCT01187108

Locations: 🇵🇪
Chronic mountain sickness clinic, Cerro de Pasco, Pasco, Peru

Acetazolamide Facilitates Ventilator Weaning

Not Applicable

Conditions: Ventilator Weaning
Alkalosis, Metabolic

Interventions: Drug: acetazolamide
Drug: Saline

First Posted Date: 2010-05-27

Last Posted Date: 2010-05-27

Lead Sponsor: Asan Medical Center

Target Recruit Count: 150

Registration Number: NCT01131377

Locations: 🇰🇷
AMC MICU; Asan medical center, Seoul, 388-1, Pungnap-dong, Songpa-gu, Korea, Republic of

Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Not Applicable

Completed

Conditions: Pulmonary Edema
Cerebral Edema

Interventions: Drug: Acetazolamide
Drug: Tadalafil and acetazolamide

First Posted Date: 2010-02-02

Last Posted Date: 2012-09-10

Lead Sponsor: Sheba Medical Center

Target Recruit Count: 55

Registration Number: NCT01060969

Locations: 🇮🇱
Center of Geographic Medicine, Tel Hashomer, Israel
🇮🇱
Sheba Medical Ctr., Tel hashomer, Israel

Idiopathic Intracranial Hypertension Treatment Trial

Phase 2

Completed

Conditions: Idiopathic Intracranial Hypertension

Interventions: Drug: Placebo
Drug: Acetazolamide
Behavioral: Formal weight loss counselling program

First Posted Date: 2009-10-29

Last Posted Date: 2018-12-12

Lead Sponsor: St. Luke's-Roosevelt Hospital Center

Target Recruit Count: 165

Registration Number: NCT01003639

Locations: 🇺🇸
Doheny Eye Center, University of Southern California, Los Angeles, California, United States
🇺🇸
The Eye Care Group, PC, Waterbury, Connecticut, United States
🇺🇸
Neuro-Ophthamology & Balance Disorders Clinic, Tallahassee, Florida, United States

and more 38 locations