Bupivacaine

Generic Name
Bupivacaine
Brand Names
Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
Drug Type
Small Molecule
Chemical Formula
C18H28N2O
CAS Number
38396-39-3
Unique Ingredient Identifier
Y8335394RO
Background

Bupivacaine is a widely used local anesthetic agent.

Indication

As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions
Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
Associated Therapies
General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

First Posted Date
2021-11-05
Last Posted Date
2023-10-26
Lead Sponsor
Heron Therapeutics
Target Recruit Count
90
Registration Number
NCT05109312
Locations
🇺🇸

Endeavor Clinical Trials, LLC, San Antonio, Texas, United States

🇺🇸

First Surgical Hospital, Bellaire, Texas, United States

🇺🇸

Legent Orthopedic Hospital, Carrollton, Texas, United States

and more 4 locations

Liposomal Bupivacaine in Benign Soft Tissue Tumor Resection

First Posted Date
2021-10-19
Last Posted Date
2021-10-19
Lead Sponsor
Samaritan Health Services
Target Recruit Count
140
Registration Number
NCT05082441
Locations
🇺🇸

Good Samaritan Regional Medical Center, Corvallis, Oregon, United States

Postoperative Pain Control in Total Shoulder Arthroplasty

First Posted Date
2021-10-06
Last Posted Date
2024-01-03
Lead Sponsor
Scripps Clinic
Target Recruit Count
150
Registration Number
NCT05068960
Locations
🇺🇸

Scripps Clinic, La Jolla, California, United States

Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades

First Posted Date
2021-09-08
Last Posted Date
2021-09-21
Lead Sponsor
Jannie Bisgaard Stæhr
Target Recruit Count
50
Registration Number
NCT05038007
Locations
🇩🇰

Aalborg University Hospital, Aalborg, Region Of Northern Jutland, Denmark

Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

First Posted Date
2021-08-23
Last Posted Date
2024-05-23
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
174
Registration Number
NCT05017246
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

First Posted Date
2021-08-13
Last Posted Date
2024-05-07
Lead Sponsor
Mayo Clinic
Target Recruit Count
88
Registration Number
NCT05005260
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Posterior Quadratus Lumborum Block Using 0.125% Versus 0.25% Bupivacaine for Analgesia in Children Undergoing LPEC

Not Applicable
Conditions
Interventions
First Posted Date
2021-08-10
Last Posted Date
2021-08-10
Lead Sponsor
Queen Sirikit National Institute of Child Health
Target Recruit Count
50
Registration Number
NCT04998071
Locations
🇹🇭

Queen Sirikit National Institute of Child Health, Ratchathewi, Bangkok, Thailand

Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty

Phase 3
Completed
Conditions
Interventions
First Posted Date
2021-07-23
Last Posted Date
2022-11-03
Lead Sponsor
University of Virginia
Target Recruit Count
80
Registration Number
NCT04974385
Locations
🇺🇸

University of Virginia Medical Center, Charlottesville, Virginia, United States

U/s Guided Oblique Subcostal Transversus Abdominis Plane Block Versus Erector Spinae Plane Block as Preemptive Analgesia

Phase 4
Completed
Conditions
Interventions
First Posted Date
2021-06-28
Last Posted Date
2022-05-06
Lead Sponsor
Benha University
Target Recruit Count
70
Registration Number
NCT04941170
Locations
🇪🇬

Banha Faculity of Medicine, Banha, Elqalyoubea, Egypt

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