Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Posterior Fossa Surgery

Phase 2

Completed

Conditions: Posterior Fossa Tumors

Interventions: Drug: Bupivacaine
Drug: morphine patient controlled analgesia

First Posted Date: 2016-08-02

Last Posted Date: 2017-08-22

Lead Sponsor: Istanbul University

Target Recruit Count: 45

Registration Number: NCT02852382

Pain Outcomes After Anterior Cruciate Ligament Reconstruction With Posterior Capsular Marcaine Injection

Not Applicable

Terminated

Conditions: Anesthesia

Interventions: Other: Ice
Drug: Marcaine
Drug: Percocet
Device: Knee Brace and Crutches

First Posted Date: 2016-07-11

Last Posted Date: 2018-09-05

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 23

Registration Number: NCT02826551

Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.

Early Phase 1

Conditions: Vasoplegia

Interventions: Drug: Bupivacaine
Drug: Bupivacaine + Morphine

First Posted Date: 2016-07-07

Last Posted Date: 2016-07-07

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 60

Registration Number: NCT02825056

Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies

Phase 4

Withdrawn

Conditions: Breast Cancer
Regional Anesthesia
Mastectomy
Post Operative Pain

Interventions: Drug: Lidocaine
Drug: Bupivacaine

First Posted Date: 2016-07-04

Last Posted Date: 2020-09-16

Lead Sponsor: The University of Texas Health Science Center, Houston

Registration Number: NCT02822196

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Spinal Anesthesia in Total Hip Arthroplasty

Phase 4

Terminated

Conditions: Total Hip Arthroplasty

Interventions: Drug: Bupivacaine
Drug: Lidocaine

First Posted Date: 2016-06-30

Last Posted Date: 2022-09-23

Lead Sponsor: Thomas L Bradbury

Target Recruit Count: 135

Registration Number: NCT02818894

Locations: 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States
🇺🇸
The Emory Clinic, Atlanta, Georgia, United States