Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

Phase 4

Withdrawn

Conditions: Total Knee Arthroplasty
Pain Management

Interventions: Drug: Cocktail
Drug: Exparel
Drug: Marcaine

First Posted Date: 2015-10-08

Last Posted Date: 2017-04-06

Lead Sponsor: University of Louisville

Registration Number: NCT02571283

Low Dose Spinal Anesthesia in Cesarean Surgery

Completed

Conditions: Maternal Hypotension
Anesthesia

Interventions: Drug: Bupivacaine
Drug: Fentanyl

First Posted Date: 2015-09-30

Last Posted Date: 2016-03-15

Lead Sponsor: Ankara University

Target Recruit Count: 100

Registration Number: NCT02563795

Locations: 🇹🇷
Cigdem Yildirim Guclu, Ankara, Turkey

Infraclavicular Perineural Dexmedetomidine

Not Applicable

Completed

Conditions: The Analgesic Effects

Interventions: Drug: Bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2015-09-16

Last Posted Date: 2017-02-28

Lead Sponsor: Cukurova University

Target Recruit Count: 60

Registration Number: NCT02550782

Locations: 🇹🇷
Erzincan Üniversity, Erzincan, Merkez, Turkey

Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor

Not Applicable

Completed

Conditions: Labor Pain

Interventions: Drug: Bupivacaine
Drug: Fentanyl
Device: Infusion pump

First Posted Date: 2015-09-15

Last Posted Date: 2016-05-03

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 40

Registration Number: NCT02550262

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Postoperative Analgesic Effects of Using Dexmedetomidine for Ultrasound Guided Thoracic Paravertebral Block

Phase 4

Completed

Conditions: Pain

Interventions: Drug: serum physiologic
Drug: bupivacaine
Drug: dexmedetomidin

First Posted Date: 2015-09-09

Last Posted Date: 2016-08-03

Lead Sponsor: TC Erciyes University

Target Recruit Count: 93

Registration Number: NCT02544893

Locations: 🇹🇷
Erciyes University Medicine Faculty, Kayseri, Turkey

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Phase 4

Completed

Conditions: Total Hip and Knee Arthroplasty

Interventions: Drug: Liposomal Bupivacaine
Drug: Ropivacaine
Drug: Bupivacaine
Drug: Clonidine
Drug: Epinephrine
Drug: Ketorolac

First Posted Date: 2015-09-07

Last Posted Date: 2019-10-18

Lead Sponsor: Kootenai Health

Target Recruit Count: 239

Registration Number: NCT02543801

Comparison of Local Anesthetic Infusion Pump Versus DepoFoam Bupivacaine for Pain Management

Phase 4

Withdrawn

Conditions: Pain

Interventions: Drug: Exparel
Drug: Marcaine

First Posted Date: 2015-09-07

Last Posted Date: 2022-02-01

Lead Sponsor: Henry Ford Health System

Registration Number: NCT02542956

Locations: 🇺🇸
Henry Ford Health System, Detroit, Michigan, United States

Obturator and Femoral Nerve Block in Patients With Hip Fracture

Phase 4

Conditions: Hip Fractures

Interventions: Drug: Saline
Drug: Bupivacaine

First Posted Date: 2015-09-04

Last Posted Date: 2016-05-16

Lead Sponsor: University of Aarhus

Target Recruit Count: 90

Registration Number: NCT02540837

Locations: 🇩🇰
Aarhus University Hospital, Aarhus, Denmark

Paravertebral Block for Inguinal Hernia Repair in Elderly

Not Applicable

Completed

Conditions: Inguinal Hernia Repair

Interventions: Other: Paravertebral block injections from T12 to L2
Other: Paravertebral block injections between T11 and L3
Other: Placebo at T11 and L3
Procedure: Herniorrhaphy
Drug: Intravenous (IV) fentanyl
Drug: Bupivacaine

First Posted Date: 2015-09-02

Last Posted Date: 2018-01-03

Lead Sponsor: Makassed General Hospital

Target Recruit Count: 200

Registration Number: NCT02537860

Locations: 🇱🇧
Makassed General Hospital, Beirut, Lebanon

Postoperative Quality of Recovery After Transurethral Resection of the Bladder

Not Applicable

Conditions: Urinary Bladder Neoplasms
Transurethral Resection of the Bladder
Postoperative Recovery

Interventions: Procedure: General anesthesia
Procedure: Spinal anesthesia
Drug: fentanyl
Drug: bupivacaine
Drug: propofol
Drug: sevoflurane

First Posted Date: 2015-08-27

Last Posted Date: 2015-08-27

Lead Sponsor: General Hospital Zadar

Target Recruit Count: 70

Registration Number: NCT02534623

Locations: 🇭🇷
General Hospital Zadar, Zadar, Croatia

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