Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy
- Conditions
- Interventions
- First Posted Date
- 2014-04-04
- Last Posted Date
- 2018-12-04
- Lead Sponsor
- St. Luke's-Roosevelt Hospital Center
- Target Recruit Count
- 11
- Registration Number
- NCT02104414
- Locations
- 🇺🇸
St.Luke's-Roosevelt Hospital Center, New York, New York, United States
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
- Conditions
- Interventions
- First Posted Date
- 2014-04-01
- Last Posted Date
- 2017-07-11
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 40
- Registration Number
- NCT02100579
- Locations
- 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients
- First Posted Date
- 2014-03-13
- Last Posted Date
- 2018-08-10
- Lead Sponsor
- Laval University
- Target Recruit Count
- 38
- Registration Number
- NCT02086474
- Locations
- 🇨🇦
Pavillon de l'Éducation Physique et des Sports - Université Laval, Quebec, Canada
Application of Combined Lumbar Plexus and Sciatic Nerve Block
- Conditions
- Interventions
- First Posted Date
- 2014-03-12
- Last Posted Date
- 2014-09-11
- Target Recruit Count
- 34
- Registration Number
- NCT02084368
- Locations
- 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China
Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair
- Conditions
- Interventions
- First Posted Date
- 2014-03-03
- Last Posted Date
- 2016-05-18
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 1
- Registration Number
- NCT02075411
- Locations
- 🇺🇸
The Children's Hospital Of Philadelphia, Philadelphia, Pennsylvania, United States
Exparel and Ankle Surgery
- First Posted Date
- 2014-02-26
- Last Posted Date
- 2016-09-23
- Lead Sponsor
- Rutgers, The State University of New Jersey
- Target Recruit Count
- 4
- Registration Number
- NCT02072135
- Locations
- 🇺🇸
University Hospital, Newark, New Jersey, United States
Trigger-point Blockade in Persistent Pain After Laparoscopical Groin Hernia Repair
- First Posted Date
- 2014-02-19
- Last Posted Date
- 2017-10-18
- Lead Sponsor
- University of Copenhagen
- Target Recruit Count
- 14
- Registration Number
- NCT02065804
- Locations
- 🇩🇰
Multidisciplinary Pain Center, Neuroscience Center, Copenhagen University Hospital, DENMARK, Copenhagen, Denmark
Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block
- Conditions
- Interventions
- First Posted Date
- 2014-02-17
- Last Posted Date
- 2015-09-14
- Lead Sponsor
- TC Erciyes University
- Target Recruit Count
- 90
- Registration Number
- NCT02064530
- Locations
- 🇹🇷
Erciyes universty, Kayseri, Melikgazi, Turkey
Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair
- First Posted Date
- 2014-02-17
- Last Posted Date
- 2016-11-28
- Lead Sponsor
- University of Copenhagen
- Target Recruit Count
- 20
- Registration Number
- NCT02065219
- Locations
- 🇩🇰
Multidisciplinary Pain Center, Neuroscience Center, Copenhagen University Hospital, DENMARK, Copenhagen, Denmark
Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)
- First Posted Date
- 2014-02-12
- Last Posted Date
- 2014-02-12
- Lead Sponsor
- Rothman Institute Orthopaedics
- Registration Number
- NCT02060591
- Locations
- 🇺🇸
Rothman Institute, Philadelphia, Pennsylvania, United States
Drug Development Updates
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