Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain

Phase 4

Completed

Conditions: Atypical Facial Pain
Typical Facial Pain

Interventions: Drug: Bupivacaine
Drug: Dexamethasone
Drug: Triamcinolone

First Posted Date: 2013-12-31

Last Posted Date: 2017-07-11

Lead Sponsor: Northwestern University

Target Recruit Count: 60

Registration Number: NCT02024724

Locations: 🇺🇸
Anesthesiology Pain Medcine Center, Chicago, Illinois, United States

Evaluation Exparel Delivered in Knee Replacement

Phase 4

Completed

Conditions: Arthritis

Interventions: Drug: Exparel
Other: Saline

First Posted Date: 2013-12-13

Last Posted Date: 2017-08-08

Lead Sponsor: Maimonides Medical Center

Target Recruit Count: 20

Registration Number: NCT02011464

Locations: 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States

Analgesic Benefits of Genicular Nerve Blocks of the Posterior Knee for Patients Undergoing ACL Reconstruction

Phase 4

Terminated

Conditions: Rupture of Anterior Cruciate Ligament

Interventions: Drug: Preservative free normal saline
Drug: Bupivacaine

First Posted Date: 2013-12-11

Last Posted Date: 2017-04-19

Lead Sponsor: Northwestern University

Target Recruit Count: 18

Registration Number: NCT02008617

Locations: 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

Effects of Epidural Local Anesthetics on Propofol Induction

Phase 4

Completed

Conditions: General Anesthesia
Propofol Target-controlled Infusion
Thoracic Epidural Anesthesia

Interventions: Drug: Normal Saline
Drug: Bupivacaine
Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2013-12-04

Last Posted Date: 2014-05-16

Lead Sponsor: First Hospital of China Medical University

Target Recruit Count: 80

Registration Number: NCT02000973

Phase III, Evaluate Noninferiority Between Levobupivacaine and Bupivacaine in Spinal Anesthesia.

Phase 3

Withdrawn

Conditions: Orthopedic Disorder of Spine

Interventions: Drug: Levobupivacaine
Drug: Bupivacaine

First Posted Date: 2013-11-26

Last Posted Date: 2017-07-21

Lead Sponsor: Cristália Produtos Químicos Farmacêuticos Ltda.

Registration Number: NCT01994967

Locations: 🇧🇷
IMIP - Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil
🇧🇷
CEMEC - Multidisciplinary Center of Clinical Studies, São Paulo, Brazil
🇧🇷
Hospital Ernesto Dornelles, Porto Alegre, RS, Brazil

and more 2 locations