Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
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Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2008-09-03

Last Posted Date: 2013-08-06

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 245

Registration Number: NCT00745290

Locations: 🇺🇸
Physicans Clinical Research Corp., Laguna Hills, California, United States
🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
🇺🇸
Accurate Clinical Trials, Inc., Laguna Hills, California, United States

and more 16 locations

Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy

Phase 3

Completed

Conditions: Hemorrhoids

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2008-09-01

Last Posted Date: 2013-08-06

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 204

Registration Number: NCT00744848

Locations: 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸
West Alabama Research Inc., Birmingham, Alabama, United States
🇺🇸
Accurate Clinical Trials, San Clemente, California, United States

and more 17 locations

Clonidine and Morphine in Caudal Anesthesia

Phase 1

Completed

Conditions: Postoperative Pain

Interventions: Drug: Bupivacaine plus clonidine and morphine
Drug: Bupivacaine
Drug: Clonidine
Drug: Morphine

First Posted Date: 2008-05-06

Last Posted Date: 2010-03-19

Lead Sponsor: Federal University of Minas Gerais

Target Recruit Count: 80

Registration Number: NCT00672347

Locations: 🇧🇷
Santa Casa de Belo Horizonte Hospital, Belo Horizonte, Minas Gerais, Brazil

Analgesic Efficacy After Umbilical Hernia Repair in Children

Not Applicable

Completed

Conditions: Umbilical Hernia

Interventions: Drug: Bupivacaine

First Posted Date: 2007-12-20

Last Posted Date: 2014-08-15

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 52

Registration Number: NCT00578136

Locations: 🇺🇸
The Children's hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis of the Knee

Interventions: Drug: ropivacaine
Drug: adrenaline
Drug: fentanyl
Drug: ketorolac
Drug: bupivacaine
Drug: morphine

First Posted Date: 2007-11-22

Last Posted Date: 2011-08-08

Lead Sponsor: Asker & Baerum Hospital

Target Recruit Count: 102

Registration Number: NCT00562627

Locations: 🇳🇴
Asker and Baerum Hospital, Rud, Norway

Continuous Bupivacaine Infusion Following Colonic Surgery

Not Applicable

Withdrawn

Conditions: Abdominal Surgery

Interventions: Drug: Bupivacaine
Drug: Saline

First Posted Date: 2007-11-14

Last Posted Date: 2018-05-21

Lead Sponsor: The Cleveland Clinic

Registration Number: NCT00557843

Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2007-09-14

Last Posted Date: 2021-03-04

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 100

Registration Number: NCT00529126

Locations: 🇬🇪
JSC Imereti Regional Clinical Hospital of the Name A. Dzotsenidze, Kutaisi, Georgia
🇬🇪
JSC K. Eristavi National Center of Experimental and Clinical Surgery, Tbilisi, Georgia
🇬🇪
Socieety with limited responsibility Proctology Center, Tbilisi, Georgia

and more 4 locations