Nefopam

Generic Name: Nefopam

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO

CAS Number: 13669-70-0

Unique Ingredient Identifier: 4UP8060B7J

Background: Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.

Indication: 用于术后镇痛、癌痛、急性外伤痛。亦可用于急性胃炎、胆道蛔虫症、输尿管结石等内脏平滑肌收缩绞痛；局部麻醉、针麻等麻醉辅助用药。

Associated Conditions: Pain

Clinical Trials

The Analgesic Efficacy of Nefopam in Orthopedics Surgery

Early Phase 1

Completed

Conditions: Pain Management
Orthopedic Procedure Pain

Interventions: Drug: Placebo
Drug: Nefopam 20 MG/ML

First Posted Date: 2024-11-08

Last Posted Date: 2024-11-08

Lead Sponsor: King Abdullah University Hospital

Target Recruit Count: 49

Registration Number: NCT06680609

Locations: 🇯🇴
King Abdullah University Hospital, Irbid, Jordan

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries.

Not Applicable

Recruiting

Conditions: Nefopam
Dexmeditomidine
Meperidine
Post-spinal Anesthesia Shivering

Interventions: Drug: Nefopam

First Posted Date: 2024-10-04

Last Posted Date: 2025-04-30

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 240

Registration Number: NCT06627816

Locations: 🇪🇬
Kasr Al Aini Hospitals, Cairo, Egypt

Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)

Phase 3

Not yet recruiting

Conditions: Total Hip Arthroplasty

Interventions: Drug: NaCl 0.9%
Drug: Nefopam

First Posted Date: 2024-04-05

Last Posted Date: 2024-04-05

Lead Sponsor: University Hospital, Tours

Target Recruit Count: 546

Registration Number: NCT06349798

Locations: 🇫🇷
Anaesthesia - Intensive care, Poitiers, France
🇫🇷
Anesthesia - intensive care, Tours, France

Role of Nefopam in Rituximab Transfusion Reaction

Phase 3

Not yet recruiting

Conditions: Nefopam

Interventions: Drug: diphenhydramine ampule
Drug: Nefopam ampule

First Posted Date: 2022-12-13

Last Posted Date: 2022-12-15

Lead Sponsor: Ministry Of Health / Nineveh Health Directorate

Target Recruit Count: 100

Registration Number: NCT05648058

Nefopam as a Multimodal Analgesia for Thoracic Surgery

Not Applicable

Completed

Conditions: Lung Cancer

Interventions: Drug: Nefopam

First Posted Date: 2021-12-29

Last Posted Date: 2023-02-14

Lead Sponsor: Kangbuk Samsung Hospital

Target Recruit Count: 46

Registration Number: NCT05173337

Locations: 🇰🇷
Eunah Cho, Seoul, Korea, Republic of

Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg)

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: nefopam hydrochloride 30mg X2
Drug: paracetamol 500 mg X2

First Posted Date: 2021-11-22

Last Posted Date: 2024-10-31

Lead Sponsor: Unither Pharmaceuticals, France

Target Recruit Count: 32

Registration Number: NCT05129137

Locations: 🇮🇳
Accutest Research Laboratories, Navi Mumbai, India

Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study

Phase 3

Recruiting

Conditions: Analgesia
Critical Illness
Mechanical Ventilation
Sedation

Interventions: Drug: Nefopam
Drug: Standard of care in the ICU for assessment and management of pain, sedation, and delirium.

First Posted Date: 2021-10-08

Last Posted Date: 2023-02-08

Lead Sponsor: Cairo University

Target Recruit Count: 60

Registration Number: NCT05071352

Locations: 🇪🇬
Cairo University Hospitals (Kasr Alainy), Cairo, Egypt

Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering.

Phase 4

Conditions: Adverse Effects in the Therapeutic Use of Anaesthetic
Shivering

Interventions: Drug: Ondansetron 8mg
Drug: Nefopam Injectable Solution

First Posted Date: 2021-05-03

Last Posted Date: 2021-05-03

Lead Sponsor: Saint-Joseph University

Target Recruit Count: 150

Registration Number: NCT04870541

Locations: 🇱🇧
Universite Saint Joseph , Hotel Dieu de France, Beirut, Lebanon

Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients

Phase 2

Recruiting

Conditions: Burn; Multiple Body Regions, Max. Second Degree
Third-Degree Burn
Burn Degree Second

Interventions: Other: Placebo (Vehicle)
Drug: Nefopam

First Posted Date: 2020-12-28

Last Posted Date: 2025-01-22

Lead Sponsor: University of Alberta

Target Recruit Count: 60

Registration Number: NCT04685577

Locations: 🇨🇦
University of Alberta Hospital, Edmonton, Alberta, Canada

Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction

Phase 3

Completed

Conditions: Acute Pain

Interventions: Combination Product: nefopam hydrochloride 30mg / paracetamol 500mg X2
Drug: Paracetamol 500 Mg Oral Tablet X2
Drug: Nefopam HCl 30 MG Oral Tablet X2

First Posted Date: 2020-11-10

Last Posted Date: 2024-11-27

Lead Sponsor: Unither Pharmaceuticals, France

Target Recruit Count: 321

Registration Number: NCT04622735

Locations: 🇷🇺
State Medico-stomato Univ., by A.I. Evdokimov, Moscow, Russian Federation
🇬🇧
University Dental Hospital, Cardiff, United Kingdom
🇷🇺
Regional clinical hospital, Yaroslavl, Russian Federation

and more 15 locations

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