MedPath

Nefopam

Generic Name
Nefopam
Drug Type
Small Molecule
Chemical Formula
C17H19NO
CAS Number
13669-70-0
Unique Ingredient Identifier
4UP8060B7J
Background

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.

Indication

用于术后镇痛、癌痛、急性外伤痛。亦可用于急性胃炎、胆道蛔虫症、输尿管结石等内脏平滑肌收缩绞痛；局部麻醉、针麻等麻醉辅助用药。

Associated Conditions
Pain
Clinical Trials
Related News

Post-operative Analgesic Effect of Oral Nefopam

Phase 2
Recruiting
Conditions
Postoperative Pain After a Total Knee Arthroplasty
Interventions
Drug: Placebo
First Posted Date
2020-10-06
Last Posted Date
2024-04-22
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
40
Registration Number
NCT04576078
Locations
🇫🇷

Département d'Anesthésie Réanimation, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France

Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS

Not Applicable
Completed
Conditions
Postoperative Pain
Interventions
Drug: Normal saline
First Posted Date
2020-06-29
Last Posted Date
2022-05-06
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
90
Registration Number
NCT04450355
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy

Phase 4
Completed
Conditions
Pain, Postoperative
Interventions
Drug: Placebo
First Posted Date
2020-01-27
Last Posted Date
2024-11-20
Lead Sponsor
Mahidol University
Target Recruit Count
72
Registration Number
NCT04241640
Locations
🇹🇭

faculty of medicine Siriraj hospital, Bangkok, Thailand

Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery

First Posted Date
2019-10-01
Last Posted Date
2019-10-01
Lead Sponsor
Centre Hospitalier Universitaire de Nīmes
Target Recruit Count
200
Registration Number
NCT04110665
Locations
🇫🇷

CHU de Nimes, Nîmes, France

Analgesic Effectiveness of Nefopam in Patients Undergoing Anterior Cervical Spine Surgery

Not Applicable
Conditions
Cervical Spine Degeneration
Interventions
Drug: Normal saline
First Posted Date
2019-05-20
Last Posted Date
2020-09-04
Lead Sponsor
Mahidol University
Target Recruit Count
50
Registration Number
NCT03955705
Locations
🇹🇭

Siriraj Hospital Mahidol University, Bangkok, Thailand

Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section

Phase 2
Completed
Conditions
Postoperative Pain
Spinal Anaesthesia During the Puerperium
Cesarean Section; Complications, Wound, Infection (Following Delivery)
Interventions
Drug: "Nefopam (Acupan)" 20 MG/ML Injectable Solution
Drug: (Acetaminophen "paracetamol") IV Soln 10 MG/ML
Drug: "Acetaminophen, (paracetamol)" 500Mg Tab
Drug: (Piroxicam "piroxan") 20 MG Oral Tablet
Drug: (Piroxicam "piroxan") 20Mg/1mL Injection
First Posted Date
2018-08-13
Last Posted Date
2018-08-15
Lead Sponsor
Centre de Maternité de Monastir
Target Recruit Count
200
Registration Number
NCT03626753
Locations
🇹🇳

Centre de Maternité de Monastir, Monastir, Tunisia

Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery

Not Applicable
Completed
Conditions
Colonic Neoplasms
Diverticulosis, Colonic
Interventions
Other: saline solution
First Posted Date
2018-08-08
Last Posted Date
2018-08-08
Lead Sponsor
Centre Hospitalier Universitaire de Nīmes
Target Recruit Count
80
Registration Number
NCT03619538

Bioequivalence Study of Nefopam Hydrochloride 30mg Tablets vs Acupan® 30mg Tablets in Healthy Subjects

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2017-10-16
Last Posted Date
2017-10-16
Lead Sponsor
Galen Limited
Target Recruit Count
29
Registration Number
NCT03311022
Locations
🇬🇧

BioKinetic Europe Ltd, Belfast, United Kingdom

The Effect of Nefopam on Catheter-related Bladder Discomfort

Not Applicable
Completed
Conditions
Nefopam
Catheter-related Bladder Discomfort
Interventions
First Posted Date
2017-04-26
Last Posted Date
2018-04-30
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
110
Registration Number
NCT03130010
Locations
🇰🇷

Seoul National Univ. Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Effectiveness of Nefopam for Thermoregulation During Surgery

Not Applicable
Completed
Conditions
Hypothermia
Interventions
First Posted Date
2017-04-21
Last Posted Date
2020-06-18
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
8
Registration Number
NCT03122665
Locations
🇨🇭

Department of Anesthesiology, University of Bern, Bern, Freiburgstrasses, Switzerland

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