Lamotrigine

Generic Name
Lamotrigine
Brand Names
Lamictal
Drug Type
Small Molecule
Chemical Formula
C9H7Cl2N5
CAS Number
84057-84-1
Unique Ingredient Identifier
U3H27498KS
Background

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 cou...

Indication

Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome.
...

Associated Conditions
Bipolar 1 Disorder, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Seizures, Generalized
Associated Therapies
Conversion to monotherapy
Clinical Trials
Related News

Lamotrigine for Ketamine Dependence Trial

Phase 2
Completed
Conditions
Addiction
Interventions
Drug: Lamotrigine
Drug: Placebo
First Posted Date
2015-09-22
Last Posted Date
2018-02-01
Lead Sponsor
Taipei City Hospital
Target Recruit Count
30
Registration Number
NCT02556060
Locations
🇨🇳

Taipei City Hospital and Psychiatric Center, Taipei, Taiwan

Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects

Phase 1
Completed
Conditions
Bipolar Disorder
Interventions
Drug: Lamotrigine
First Posted Date
2015-07-31
Last Posted Date
2017-05-08
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
16
Registration Number
NCT02513654
Locations
🇨🇳

GSK Investigational Site, Shanghai, China

16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression

Phase 4
Terminated
Conditions
Bipolar Disorder
Interventions
Drug: Lamotrigine
Drug: Fluoxetine
First Posted Date
2015-03-17
Last Posted Date
2019-06-19
Lead Sponsor
Mayo Clinic
Target Recruit Count
2
Registration Number
NCT02389712
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Interaction Between Paracetamol and Lamotrigine: A Clinical Interaction Study

Phase 4
Completed
Conditions
Healthy
Interventions
Drug: Lamotrigine
First Posted Date
2014-11-27
Last Posted Date
2015-04-22
Lead Sponsor
Per Damkier
Target Recruit Count
12
Registration Number
NCT02303106
Locations
🇩🇰

University of Southern Denmark, Odense, Denmark

Open-label Drug Interaction Study Between Eslicarbazepine Acetate and Lamotrigine.

Phase 1
Completed
Conditions
Epilepsy
Interventions
Drug: Eslicarbazepine acetate
Drug: Lamotrigine
First Posted Date
2014-11-05
Last Posted Date
2014-11-05
Lead Sponsor
Bial - Portela C S.A.
Target Recruit Count
32
Registration Number
NCT02283801

Effect of Lamotrigine on Cognition in NF1

Phase 2
Terminated
Conditions
Neurofibromatosis Type 1
Interventions
Drug: Placebo
Drug: Lamotrigine
First Posted Date
2014-10-03
Last Posted Date
2020-04-14
Lead Sponsor
Erasmus Medical Center
Target Recruit Count
41
Registration Number
NCT02256124
Locations
🇧🇪

University Hospital Leuven, Leuven, Belgium

🇳🇱

Erasmus Medical Center, Rotterdam, South Holland, Netherlands

🇪🇸

Hospital Sant Joan de Deu, Barcelona, Spain

Study of Lamotrigine to Treat Ménière's Disease

First Posted Date
2014-06-09
Last Posted Date
2022-06-22
Lead Sponsor
Dent Neuroscience Research Center
Target Recruit Count
15
Registration Number
NCT02158585
Locations
🇺🇸

Dent Neurologic Institute, Amherst, New York, United States

Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?

Phase 1
Completed
Conditions
Bipolar Disorder
Manic Depression
Interventions
Drug: IP6
Drug: Lamotrigine
First Posted Date
2014-03-07
Last Posted Date
2018-08-01
Lead Sponsor
San Diego Veterans Healthcare System
Target Recruit Count
8
Registration Number
NCT02081287
Locations
🇺🇸

VA San Diego Healthcare System, San Diego, California, United States

Pregnant Women Taking Lamictal for Bipolar Disorder

Completed
Conditions
Bipolar Disorder
Interventions
Drug: lamotrigine
First Posted Date
2013-11-27
Last Posted Date
2022-09-28
Lead Sponsor
Northwestern University
Target Recruit Count
30
Registration Number
NCT01996293
Locations
🇺🇸

Northwestern Memorial Hospital, Chicago, Illinois, United States

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