MedPath

Primaquine

Generic Name
Primaquine
Drug Type
Small Molecule
Chemical Formula
C15H21N3O
CAS Number
90-34-6
Unique Ingredient Identifier
MVR3634GX1
Background

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)

Indication

For the treatment of malaria.

Associated Conditions
Malaria, Malaria caused by Plasmodium ovale, Malaria caused by plasmodium vivax, Pneumocystis Jirovecii Pneumonia
Clinical Trials
Related News

Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas

Phase 4
Completed
Conditions
Falciparum Malaria
Malaria
Vivax Malaria
Interventions
First Posted Date
2019-04-16
Last Posted Date
2023-11-21
Lead Sponsor
Menzies School of Health Research
Target Recruit Count
500
Registration Number
NCT03916003
Locations
🇪🇹

Arba Minch University, Arba Minch, Ethiopia

🇧🇩

Icddrb, Upazila, Bangladesh

🇮🇩

Puskesmas Mangili, Dusun Tenggara, Indonesia

Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic

Phase 4
Completed
Conditions
Plasmodium Falciparum Malaria
Interventions
Diagnostic Test: Standard RDT and HS-RDT
First Posted Date
2018-12-21
Last Posted Date
2021-02-23
Lead Sponsor
University of California, San Francisco
Target Recruit Count
39968
Registration Number
NCT03783299
Locations
🇱🇦

Centre for Marialogy, Parasitology, and Entomology, Vientiane, Lao People's Democratic Republic

Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil

Not Applicable
Completed
Conditions
Malaria, Vivax
P Vivax
Interventions
First Posted Date
2018-08-01
Last Posted Date
2021-08-09
Lead Sponsor
Centers for Disease Control and Prevention
Target Recruit Count
257
Registration Number
NCT03610399
Locations
🇧🇷

Hospital do Jurua, Cruzeiro do Sul, Brazil

Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients

Phase 2
Completed
Conditions
Vivax Malaria
G6PD Deficiency
Interventions
First Posted Date
2018-05-18
Last Posted Date
2025-02-20
Lead Sponsor
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Target Recruit Count
106
Registration Number
NCT03529396
Locations
🇧🇷

Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil

🇧🇷

Centro de Pesquisa em Medicina Tropical (Cepem), Porto Velho, RO, Brazil

Single Low-dose Primaquine Efficacy and Safety.

Phase 4
Completed
Conditions
Malaria
Interventions
First Posted Date
2017-11-24
Last Posted Date
2023-02-24
Lead Sponsor
Tropical Pesticides Research Institute, Tanzania
Target Recruit Count
157
Registration Number
NCT03352843
Locations
🇹🇿

Tropical Pesticides Research Institute (TPRI), Arusha, Tanzania

Assessing a Risk Model for G6PD Deficiency

Phase 4
Terminated
Conditions
Malaria, Vivax
G6PD Deficiency
Interventions
First Posted Date
2017-11-08
Last Posted Date
2021-11-12
Lead Sponsor
PATH
Target Recruit Count
54
Registration Number
NCT03337152
Locations
🇹🇭

Shoklo Malaria Research Unit (SMRU), Mae Sot, Thailand

"Prolonging the Therapeutic Life Span of Artemisinin-based Combination Therapies (ACT) in Bagamoyo District, Tanzania"

Phase 4
Completed
Conditions
Malaria,Falciparum
Interventions
Drug: Artemether-Lumefantrine Tab 20-120mg
Other: Placebo
First Posted Date
2017-08-08
Last Posted Date
2018-03-27
Lead Sponsor
Muhimbili University of Health and Allied Sciences
Target Recruit Count
280
Registration Number
NCT03241901
Locations
🇹🇿

Fukayosi Dispensary, Bagamoyo, Pwani, Tanzania

🇹🇿

Yombo Dispensary, Bagamoyo, Yombo, Tanzania

Genetic Variability in CYP2D6 in U.S Active Duty Population

Phase 1
Completed
Conditions
Pharmacologic Action
Interventions
First Posted Date
2016-11-09
Last Posted Date
2021-10-20
Lead Sponsor
Walter Reed Army Institute of Research (WRAIR)
Target Recruit Count
550
Registration Number
NCT02960568
Locations
🇺🇸

WRAIR, Silver Spring, Maryland, United States

G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria

First Posted Date
2016-08-23
Last Posted Date
2020-10-14
Lead Sponsor
University of Oxford
Target Recruit Count
1000
Registration Number
NCT02876549
Locations
🇦🇫

Dr. Ghulam Rahim Awab MD, Jalalabad, Nangarha, Afghanistan

Methylene Blue Against Falciparum Malaria in Burkina Faso

Phase 2
Completed
Conditions
Malaria, Falciparum
Interventions
First Posted Date
2016-08-01
Last Posted Date
2020-03-25
Lead Sponsor
Heidelberg University
Target Recruit Count
100
Registration Number
NCT02851108
Locations
🇧🇫

CRSN, Nouna, Burkina Faso

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