Primaquine

Generic Name: Primaquine

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₂₁N_₃O

CAS Number: 90-34-6

Unique Ingredient Identifier: MVR3634GX1

Background: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI dis...

Indication: For the treatment of malaria.

Associated Conditions: Malaria, Malaria caused by Plasmodium ovale, Malaria caused by plasmodium vivax, Pneumocystis Jirovecii Pneumonia

Associated Therapies: -

Clinical Trials

Methylene Blue Against Falciparum Malaria in Burkina Faso

Phase 2

Completed

Conditions: Malaria, Falciparum

Interventions: Drug: Primaquine
Drug: Methylene Blue

First Posted Date: 2016-08-01

Last Posted Date: 2020-03-25

Lead Sponsor: Heidelberg University

Target Recruit Count: 100

Registration Number: NCT02851108

Locations: 🇧🇫
CRSN, Nouna, Burkina Faso

Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria

Phase 3

Completed

Conditions: Malaria, Vivax

Interventions: Drug: Matched-Placebo for Tafenoquine
Drug: Tafenoquine
Drug: Matched-Placebo for Primaquine
Drug: Primaquine
Drug: Dihydroartemisinin-piperaquine (DHA-PQP)
Drug: ACT plus PQ (Rescue medication)
Drug: PQ (End of study treatment)

First Posted Date: 2016-06-16

Last Posted Date: 2020-07-24

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 150

Registration Number: NCT02802501

Locations: 🇮🇩
GSK Investigational Site, Jakarta, Indonesia

Pharmacokinetic Study of Primaquine in Healthy Obese Thai Adult Subjects

Phase 1

Completed

Conditions: Obese

Interventions: Drug: Primaquine

First Posted Date: 2016-06-03

Last Posted Date: 2016-06-03

Lead Sponsor: University of Oxford

Target Recruit Count: 10

Registration Number: NCT02789566

Locations: 🇹🇭
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Study of Artemether-lumefantrine, Amodiaquine and Primaquine in Healthy Subjects

Phase 1

Terminated

Conditions: Drug Combination
Healthy
Pharmacokinetic

Interventions: Drug: Artemether-lumefantrine
Drug: Amodiaquine
Drug: Artemether-lumefantrine + Amodiaquine
Drug: Primaquine
Drug: Artemether-lumefantrine + Amodiaquine + Primaquine
Drug: Artemether-lumefantrine + Primaquine

First Posted Date: 2016-03-02

Last Posted Date: 2019-06-28

Lead Sponsor: University of Oxford

Target Recruit Count: 17

Registration Number: NCT02696954

Locations: 🇹🇭
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection

Phase 2

Completed

Conditions: Malaria, Vivax

Interventions: Drug: Chloroquine
Drug: Primaquine

First Posted Date: 2016-02-25

Last Posted Date: 2016-02-25

Lead Sponsor: Oswaldo Cruz Foundation

Target Recruit Count: 204

Registration Number: NCT02691910

Locations: 🇧🇷
Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
🇧🇷
Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil

Malaria Elimination Pilot Study in Military Forces in Cambodia

Phase 4

Conditions: Malaria
Parasitic Diseases

Interventions: Drug: DHA-PIP
Drug: Primaquine
Drug: Artesunate + Mefloquine
Drug: Permethrin (Insecticide treated uniform)

First Posted Date: 2016-01-13

Last Posted Date: 2021-03-02

Lead Sponsor: Armed Forces Research Institute of Medical Sciences, Thailand

Target Recruit Count: 1050

Registration Number: NCT02653898

Locations: 🇰🇭
RCAF treatment facilities, Anlong Veng, Oddar Meancheay, Cambodia

Determining a Tolerable Dose of Primaquine in G6PD-deficient Persons Without Malaria in Mali

Phase 1

Completed

Conditions: Malaria

Interventions: Drug: Primaquine

First Posted Date: 2015-08-31

Last Posted Date: 2017-02-06

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 28

Registration Number: NCT02535767

Locations: 🇲🇱
Malaria Research and Training Centre, Bamako, Mali

Safety and Tolerability of Low Dose Primaquine

Phase 4

Completed

Conditions: Malaria, Falciparum
G6PD Deficiency

Interventions: Drug: Dihydroartemisinin piperaquine (DHA PP)
Drug: Primaquine

First Posted Date: 2015-05-06

Last Posted Date: 2016-08-23

Lead Sponsor: Malaria Consortium

Target Recruit Count: 109

Registration Number: NCT02434952

Locations: 🇰🇭
Ratanakiri Provincial Hospital, Ratanakiri, Cambodia

Effectiveness of OZ439 as a Gametocytocidal and Transmission Blocking Agent

Phase 1

Completed

Conditions: Malaria

Interventions: Drug: OZ439
Drug: Primaquine

First Posted Date: 2015-05-01

Last Posted Date: 2020-05-26

Lead Sponsor: Medicines for Malaria Venture

Target Recruit Count: 11

Registration Number: NCT02431650

Locations: 🇦🇺
Q-Pharm Clinics, Herston, Queensland, Australia

Effectiveness of Malaria Treatment in Mexico

Phase 4

Completed

Conditions: Malaria

Interventions: Drug: Chloroquine phosphate
Drug: primaquine

First Posted Date: 2015-03-20

Last Posted Date: 2015-03-20

Lead Sponsor: LILIA GONZALEZ CERON

Target Recruit Count: 153

Registration Number: NCT02394197

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