Primaquine
- Generic Name
- Primaquine
- Drug Type
- Small Molecule
- Chemical Formula
- C15H21N3O
- CAS Number
- 90-34-6
- Unique Ingredient Identifier
- MVR3634GX1
- Background
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
- Indication
For the treatment of malaria.
- Associated Conditions
- Malaria, Malaria caused by Plasmodium ovale, Malaria caused by plasmodium vivax, Pneumocystis Jirovecii Pneumonia
Clinical Investigation Study to Evaluate the Consistency and Reproducibility of Two Consecutive Mosquito Feeding Assays
- Conditions
- Malaria
- Interventions
- First Posted Date
- 2020-12-14
- Last Posted Date
- 2024-04-29
- Lead Sponsor
- PATH
- Target Recruit Count
- 42
- Registration Number
- NCT04666350
- Locations
- 🇰🇪
KEMRI, Kombewa, Kenya
Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With Anti-malarial Therapy
- Conditions
- Plasmodium Falciparum
- Interventions
- Biological: Abhayrab rabies vaccineBiological: Malaria Vaccine RTS,S/AS01EDrug: Dihydroartemisinin-piperaquine (DHA/Pip)
- First Posted Date
- 2020-12-10
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- PATH
- Target Recruit Count
- 620
- Registration Number
- NCT04661579
- Locations
- 🇰🇪
Lucas O Tina, Kisumu, Kisumu County, Kenya
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
- Conditions
- Vivax MalariaPlasmodium VivaxMalaria, VivaxMalaria Relapse
- Interventions
- First Posted Date
- 2020-06-02
- Last Posted Date
- 2024-10-07
- Lead Sponsor
- Menzies School of Health Research
- Target Recruit Count
- 960
- Registration Number
- NCT04411836
- Locations
- 🇵🇰
Aga Khan Hospital Karachi, Karachi, Pakistan
🇰🇭Kravanh District Hospital, Pursat, Pursat Province, Cambodia
🇰🇭Siem Pang Health Centre, Stung Treng, Cambodia
The Fleming [FMTVDM] Directed CoVid-19 Treatment Protocol
- Conditions
- CoVid 19 Positive
- Interventions
- Drug: Convalescent Serum
- First Posted Date
- 2020-04-16
- Last Posted Date
- 2020-11-12
- Lead Sponsor
- The Camelot Foundation
- Target Recruit Count
- 1800
- Registration Number
- NCT04349410
- Locations
- 🇺🇸
FHHI-OI-Camelot; QME, Los Angeles, California, United States
Controlled Human Malaria Infection Transmission Model - Phase A
- Conditions
- Malaria,Falciparum
- Interventions
- Biological: PfSPZ Challenge
- First Posted Date
- 2020-02-21
- Last Posted Date
- 2024-05-23
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 44
- Registration Number
- NCT04280692
- Locations
- 🇰🇪
KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
Biomarkers of P. Vivax Relapse
- Conditions
- Vivax MalariaRelapseMalariaCYP2D6 Polymorphism
- Interventions
- First Posted Date
- 2020-01-14
- Last Posted Date
- 2020-01-14
- Lead Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
- Target Recruit Count
- 100
- Registration Number
- NCT04228315
- Locations
- 🇹🇭
Khun Han Hospital, Khun Han, Thailand
TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014
- Conditions
- MalariaVivax MalariaFalciparum MalariaMalaria Recrudescence
- Interventions
- First Posted Date
- 2020-01-09
- Last Posted Date
- 2023-07-21
- Lead Sponsor
- Research Institute for Tropical Medicine, Philippines
- Target Recruit Count
- 159
- Registration Number
- NCT04222088
Short Course Radical Cure of P. Vivax Malaria in Nepal
- First Posted Date
- 2019-09-06
- Last Posted Date
- 2024-08-29
- Lead Sponsor
- Menzies School of Health Research
- Target Recruit Count
- 27
- Registration Number
- NCT04079621
- Locations
- 🇳🇵
Tikapur Hospital, Tikapur, Nepal
🇳🇵Malakheti Hospital, Malakheti, Nepal
Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission
- Conditions
- Malaria,Falciparum
- Interventions
- First Posted Date
- 2019-08-08
- Last Posted Date
- 2020-01-30
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 100
- Registration Number
- NCT04049916
- Locations
- 🇲🇱
Malaria Research and Training Centre, Bamako, Mali
🇳🇱Radboud university medical center, Nijmegen, Netherlands
Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen
- Conditions
- MalariaGlucose 6 Phosphate Dehydrogenase Deficiency
- Interventions
- First Posted Date
- 2019-05-01
- Last Posted Date
- 2019-05-14
- Lead Sponsor
- University of Mississippi, Oxford
- Target Recruit Count
- 36
- Registration Number
- NCT03934450
- Locations
- 🇺🇸
University of Mississippi, University, Mississippi, United States
Drug Development Updates
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