A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients with Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
- Conditions
- AML (Acute Myelogenous Leukemia)Acute Lymphoid Leukemia (ALL)Acute Leukemia (Category)MDS (Myelodysplastic Syndrome)CML (Chronic Myelogenous Leukemia)CLL (Chronic Lymphocytic Leukemia)Prolymphocyctic LeukemiaChronic Myelomonocytic Leukemia (CMML)Myeloproliferative Neoplasm (MPN)Lymphoma
- Interventions
- Drug: Conditioning Regimen ADrug: Conditioning Regimen BDrug: Conditioning Regimen CDrug: Conditioning Regimen DDrug: Conditioning Regimen EProcedure: Hematopoietic Cell TransplantationDrug: PTCy (50 mg/kg D3, D4)Drug: PTCy (25 mg/kg D3, D4)Drug: Post-transplant TacrolimusDrug: Post-transplant Mycophenolate mofetilDrug: Post-transplant AbataceptDrug: Post-transplant RuxolitinibOther: Study treatment complianceOther: Prohibited Concomitant TherapyOther: Permitted Concomitant Therapy
- First Posted Date
- 2025-03-05
- Last Posted Date
- 2025-03-12
- Target Recruit Count
- 358
- Registration Number
- NCT06859424
HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis
- Conditions
- Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myeloid LeukemiaChronic Lymphocytic LeukemiaChronic Myelomonocytic LeukemiaAcute LeukemiaPro-Lymphocytic LeukemiaAcute Lymphoblastic LeukemiaMyelofibrosisMyeloproliferative Neoplasm
- Interventions
- Procedure: PBSC Hematopoietic Stem Cell Transplantation (HSCT)Other: Patient Reported OutcomesRadiation: Total-body irradiation
- First Posted Date
- 2023-08-21
- Last Posted Date
- 2025-04-03
- Target Recruit Count
- 190
- Registration Number
- NCT06001385
- Locations
- 🇺🇸
Honor Health, Scottsdale, Arizona, United States
🇺🇸University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
🇺🇸Mayo Clinic Jacksonville, Jacksonville, Florida, United States
Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events
- Conditions
- Acute Myeloid Leukemia in Remission
- Interventions
- Other: Prospective determination of the clinical utility of measurable residual disease (MRD) testing
- First Posted Date
- 2022-02-04
- Last Posted Date
- 2025-04-25
- Target Recruit Count
- 303
- Registration Number
- NCT05224661
- Locations
- 🇺🇸
City of Hope, Duarte, California, United States
🇺🇸University of California, San Francisco, San Francisco, California, United States
🇺🇸Stanford University, Stanford, California, United States
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
- Conditions
- Marrow Toxic InjuryCellular TherapyAllogeneic Stem Cell TransplantationAutologous Stem Cell Transplantation
- First Posted Date
- 2021-06-09
- Last Posted Date
- 2023-05-03
- Target Recruit Count
- 99999999
- Registration Number
- NCT04920474
- Locations
- 🇺🇸
NMDP Biorepository, New Brighton, Minnesota, United States
HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide
- Conditions
- Chronic Myelogenous LeukemiaMixed Phenotype Acute LeukemiaAcute LeukemiaAcute Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaAcute Myelogenous LeukemiaMyelodysplastic SyndromesLymphoma
- Interventions
- Radiation: Total-body irradiationProcedure: PBSC Hematopoietic Stem Cell Transplantation (HSCT)Procedure: Bone Marrow Hematopoietic Stem Cell TransplantationOther: Patient-Reported Outcomes
- First Posted Date
- 2021-05-27
- Last Posted Date
- 2024-05-23
- Target Recruit Count
- 300
- Registration Number
- NCT04904588
- Locations
- 🇺🇸
Levine Cancer Institute, Charlotte, North Carolina, United States
🇺🇸Ohio State Medical Center, James Cancer Center, Columbus, Ohio, United States
🇺🇸City of Hope National Medical Center, Duarte, California, United States
Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704)
- Conditions
- Hematologic Malignancy
- Interventions
- Diagnostic Test: Age 60+ with planned HCT for Hematologic Malignancy
- First Posted Date
- 2019-06-20
- Last Posted Date
- 2024-02-06
- Target Recruit Count
- 1229
- Registration Number
- NCT03992352
- Locations
- 🇺🇸
UMass Memorial Medical Center, Worcester, Massachusetts, United States
🇺🇸The Ohio State Universtiy, Columbus, Ohio, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia
- Conditions
- Acute Myelogenous Leukemia
- Interventions
- Biological: CD33CART allogeneicBiological: CD33CART autologous
- First Posted Date
- 2019-06-03
- Last Posted Date
- 2025-05-04
- Target Recruit Count
- 52
- Registration Number
- NCT03971799
- Locations
- 🇺🇸
Children's Hospital of Los Angeles, Los Angeles, California, United States
🇺🇸Children's Hospital of Colorado, Aurora, Colorado, United States
🇺🇸National Cancer Institute - NIH, Bethesda, Maryland, United States
Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)
- Conditions
- Myelodysplastic SyndromesHodgkin LymphomaAcute Lymphoblastic LeukemiaSickle Cell DiseaseAcute Myeloid LeukemiaNon-hodgkin LymphomaAcquired Aplastic Anemia
- Interventions
- Other: Donor Search Prognosis Score
- First Posted Date
- 2019-04-05
- Last Posted Date
- 2025-04-11
- Target Recruit Count
- 1753
- Registration Number
- NCT03904134
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸Dana Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors
- Conditions
- Quality of Life
- First Posted Date
- 2018-10-24
- Last Posted Date
- 2025-03-18
- Target Recruit Count
- 754
- Registration Number
- NCT03718546
- Locations
- 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Vanderbilt University Medical Center, Nashville, Tennessee, United States
🇺🇸Children's Health (formerly Children's Medical Center Dallas), Dallas, Texas, United States
Conditioning SCID Infants Diagnosed Early
- Conditions
- SCID
- Interventions
- Device: Cell processing for TCRαβ+/CD19+ depletion
- First Posted Date
- 2018-08-08
- Last Posted Date
- 2025-04-24
- Target Recruit Count
- 56
- Registration Number
- NCT03619551
- Locations
- 🇺🇸
Univeristy of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸Mayo Clinic Arizona and Phoenix Children's Hospital, Phoenix, Arizona, United States
🇺🇸Children's Hospital Los Angeles, Los Angeles, California, United States