CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST

🇬🇧United Kingdom

Country: 🇬🇧United Kingdom

Ownership: Subsidiary

Established: 1992-11-04

Employees: 10K

Market Cap: -

Website: http://www.cuh.org.uk

Clinical Trials

Pregnancy Related Inappropriate Sinus Tachycardia

Conditions: Pregnancy Related
Inappropriate Sinus Tachycardia

Interventions: Diagnostic Test: ECG
Diagnostic Test: heart rate monitor
Diagnostic Test: Autonomic Nervous System (ANS) Activity
Diagnostic Test: Haemodynamic variables
Other: Echocardiogram

First Posted Date: 2017-10-23

Last Posted Date: 2019-01-22

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 200

Registration Number: NCT03317249

Locations: 🇬🇧
Addenbrookes Hospital, Cambridge, United Kingdom

Validation of the Analysis Methodology Behind the Use of Quantitative 18F-FDG PET/CT to Assess Lung Inflammation

Conditions: Lung Inflammation
Sarcoidosis

Interventions: Radiation: PET/CT scan
Diagnostic Test: Blood and urine sampling
Other: LPS Challenge
Other: Saline Challenge

First Posted Date: 2017-10-18

Last Posted Date: 2020-01-09

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 36

Registration Number: NCT03312712

Locations: 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
🇬🇧
Royal Papworth Hospital NHS Foundation Trust, Papworth Everard, United Kingdom

The Role of Circuit Flow During Mechanical Ventilation of Neonates

Not Applicable

Completed

Conditions: Respiratory Distress Syndrome in Premature Infant

Interventions: Device: SIPPV_VG_0_32
Device: SIPPV_VG_0_08
Device: PSV_VG_0_08
Device: SIPPV_VG_0_24
Device: PSV_VG_0_24
Device: PSV_VG_0_32
Device: SIPPV_VG_0_16
Device: PSV_VG_0_16
Device: SIPPV_VG_0_40
Device: PSV_VG_0_40

First Posted Date: 2017-10-11

Last Posted Date: 2019-05-20

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 12

Registration Number: NCT03306524

Locations: 🇬🇧
Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom

A Pre-operative Window Study of Letrozole Plus PR Agonist (Megestrol Acetate) Versus Letrozole Alone in Post-menopausal Patients With ER-positive Breast Cancer

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: Megestrol Acetate 40 MG
Drug: Megestrol Acetate 160 MG
Drug: Letrozole

First Posted Date: 2017-10-11

Last Posted Date: 2024-01-30

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 198

Registration Number: NCT03306472

Locations: 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers

Not Applicable

Completed

Conditions: Atherosclerosis
Cardiovascular Diseases

Interventions: Other: Written Informed Consent
Other: Inclusion/Exclusion check
Other: Full Clinical Chemistry and Haematology Bloods
Other: Serum sample for systemic markers and lipid sub-fractions
Other: Pregnancy Test
Other: 12 Lead ECG
Other: Blood Pressure and Heart Rate
Other: Arterial Stiffness
Other: Central Haemodynamics
Other: Carotid Intima Media Thickness
Other: Forearm blood flow studies
Other: Concomitant medication check
Other: Medication compliance check (Pill count)
Other: Physical examination
Other: Medical history
Other: AE/SAE review & reporting
Drug: Dosing

First Posted Date: 2017-09-06

Last Posted Date: 2023-07-27

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 30

Registration Number: NCT03273972

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Gaucherite - A Study to Stratify Gaucher Disease

Recruiting

Conditions: Gaucher Disease, Type III
Gaucher Disease, Type I

Interventions: Other: Stratified response to Enzyme Therapy

First Posted Date: 2017-08-07

Last Posted Date: 2024-08-06

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 250

Registration Number: NCT03240653

Locations: 🇬🇧
Salford Royal NHS Foundation Trust, Salford, United Kingdom
🇬🇧
Royal Manchester Childrens Hospital, Manchester, United Kingdom
🇬🇧
Cambridge University Hospital, Cambridge, United Kingdom

and more 5 locations

Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and/or Germline BRCA Positive Breast Cancer

Phase 2

Recruiting

Conditions: Breast Cancer

Interventions: Drug: Paclitaxel and Carboplatin
Drug: Olaparib

First Posted Date: 2017-05-12

Last Posted Date: 2022-11-14

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 780

Registration Number: NCT03150576

Locations: 🇬🇧
The Christie, Manchester, Lancs, United Kingdom
🇬🇧
University Hospital Ayr, Ayr, United Kingdom
🇬🇧
Bedford General Hospital, Bedford, United Kingdom

and more 26 locations

Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes

Phase 1

Completed

Conditions: Ischemic Heart Disease

Interventions: Drug: Proleukin
Drug: Placebo Injection

First Posted Date: 2017-04-14

Last Posted Date: 2021-09-14

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 41

Registration Number: NCT03113773

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

Phase 1

Terminated

Conditions: Drug-Related Side Effects and Adverse Reactions
Cardiovascular System Disease

Interventions: Drug: Albuterol Sulfate
Drug: Phenylephrine Hydrochloride
Drug: Nicardipine Hydrochloride
Drug: Verapamil Hydrochloride
Drug: Phentolamine Mesylate
Drug: Dobutamine Hydrochloride
Drug: Placebo

First Posted Date: 2017-04-04

Last Posted Date: 2021-03-22

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 18

Registration Number: NCT03098680

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

APRIL (AbatacePt in Rheumatoid Arthritis-ILD)

Phase 2

Conditions: Interstitial Lung Disease
Rheumatoid Arthritis

Interventions: Drug: Abatacept

First Posted Date: 2017-03-21

Last Posted Date: 2019-07-22

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 30

Registration Number: NCT03084419

Locations: 🇬🇧
Papworth Hospital, Cambridge, United Kingdom
🇬🇧
Addenbrookes Hospital, Cambridge, United Kingdom

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