CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST

🇬🇧United Kingdom

Country: 🇬🇧United Kingdom

Ownership: Subsidiary

Established: 1992-11-04

Employees: 10K

Market Cap: -

Website: http://www.cuh.org.uk

Clinical Trials

Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

Terminated

Conditions: Cardiovascular Diseases

Interventions: Other: Eligibility and lifestyle restrictions check.
Other: Medical history, demographic and lifestyle factors
Other: Blood pressure and heart rate
Other: Blood biochemistry (PNPLA3)
Other: Blood EPCR function (PROCR)
Other: Baseline Venepuncture (PNPLA3, Visit 1)
Other: Blood platelet coagulation and function (PROCR)
Other: Deuterium water - Loading dose 1 (PNPLA3, Visit 1)
Other: Blood endothelial permeability (PROCR)
Other: Deuterium water - Loading dose 2 (PNPLA3, Visit 1)
Other: Blood leukocyte-endothelium adhesion (PROCR)
Other: Energy-balanced dinner (PNPLA3, Visit 1)
Other: Venepuncture (PROCR)
Other: Fasting venepuncture (PNPLA3, Visit 2)
Other: Deuterium water - Maintenance dose (PNPLA3, Visit 2)
Other: Consumption of high carbohydrate meal (PNPLA3, Visit 2)
Other: Postprandial Venepuncture (PNPLA3, Visit 2)

First Posted Date: 2017-02-01

Last Posted Date: 2024-02-02

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 74

Registration Number: NCT03038750

Locations: 🇬🇧
Department of Public Health and Primary Care, Cambridge, United Kingdom

Infrared Choroidal Reflectance Camera for the Detection of Childhood Cataract

Completed

Conditions: Childhood Cataract

Interventions: Diagnostic Test: Red-reflex assessment
Diagnostic Test: Infrared-reflex assessment

First Posted Date: 2017-01-30

Last Posted Date: 2023-11-07

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 110

Registration Number: NCT03035292

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Influence of Age, Weight and Ethnic Background on Blood Pressure

Conditions: Cardiovascular Diseases
Vascular Diseases
Hypertension

Interventions: Other: Brief lifestyle/medical history questionnaire
Other: Anthropometric measures
Other: Blood pressure and arterial stiffness
Other: Cardiac output and lung function
Other: Heart rate variability
Other: Blood sample & spot urine sample
Other: 24 hour ambulatory blood pressure monitor
Other: 24 hour urine collection
Other: Large artery endothelial function
Other: Dundee step test
Other: Detailed haemodynamic response to submaximal exercise
Other: Haemodynamic response to mental stress

First Posted Date: 2017-01-09

Last Posted Date: 2022-08-23

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 500

Registration Number: NCT03014791

Locations: 🇬🇧
Vascular Research Clinic, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.

Completed

Conditions: Chronic Kidney Disease
Cardiovascular Diseases

Interventions: Drug: Darbepoetin Alfa
Drug: Acetylcholine
Drug: Noradrenaline
Drug: BQ 123

First Posted Date: 2016-12-09

Last Posted Date: 2024-02-07

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 29

Registration Number: NCT02987465

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Gastrectomy, Eating Behaviour and GLP-1

Not Applicable

Completed

Conditions: Dumping Syndrome
Gastric Cancer

Interventions: Other: Placebo
Other: Exendin 9-39

First Posted Date: 2016-11-23

Last Posted Date: 2019-08-29

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 5

Registration Number: NCT02971631

Locations: 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

High Water Intake in Polycystic Kidney Disease

Not Applicable

Completed

Conditions: Autosomal Dominant Polycystic Kidney Disease

Interventions: Other: Ad libitum water intake
Dietary Supplement: High water intake

First Posted Date: 2016-10-14

Last Posted Date: 2019-01-15

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 42

Registration Number: NCT02933268

Locations: 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children

Not Applicable

Conditions: Small for Gestational Age

Interventions: Drug: Growth Hormone
Drug: Metformin
Drug: Placebo

First Posted Date: 2016-10-13

Last Posted Date: 2016-10-14

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 24

Registration Number: NCT02931591

The Effect of Anacetrapib on Vascular Function and Arterial Stiffness

Completed

Conditions: Atherosclerotic Cardiovascular Disease
Vascular Disease

Interventions: Drug: Statin
Drug: Anacetrapib
Drug: Placebo

First Posted Date: 2016-10-12

Last Posted Date: 2024-02-07

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 103

Registration Number: NCT02931188

Locations: 🇬🇧
Clinical Investigation Ward, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Advanced MR Imaging of Osteoarthritis

Completed

Conditions: Osteoarthritis

First Posted Date: 2016-08-30

Last Posted Date: 2019-01-15

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 20

Registration Number: NCT02883907

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Comparison of Optimal Hypertension Regimens

Phase 4

Conditions: Hypertension

Interventions: Drug: Amlodipine
Drug: Lisinopril
Drug: Amiloride
Drug: Chlortalidone

First Posted Date: 2016-07-28

Last Posted Date: 2021-07-28

Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Target Recruit Count: 1320

Registration Number: NCT02847338

Locations: 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
🇬🇧
University Hospital Llandough, Cardiff, United Kingdom
🇬🇧
Queen Elizabeth Hospital, Birmingham, United Kingdom

and more 11 locations

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