Effects of Sedentary Behaviour on Metabolic Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Blood Pressure
研究概览
简要总结
The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.
详细描述
There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.
Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.
This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years of age or older
- •type 2 diabetes managed with diet or oral hypoglycemic agents
排除标准
- •using insulin to manage diabetes
- •baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L
- •any medical condition that would limit the ability to perform activity portion of the study
- •people not comfortable exercising on a stationary bicycle
- •subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire
结局指标
主要结局
Blood Pressure
时间窗: every 60 minutes for 4 hours
次要结局
- C Reactive Protein(every 60 minutes for 4 hours)
- Insulin Levels(every 60 minutes for 4 hours)
- Blood glucose levels(every 60 minutes for 4 hours)
研究者
Kenneth Madden
Head, VGH Division of Geriatric Medicine
University of British Columbia