Effects of supervised structured aerobic exercise training (SSAET) on patients with type 2 diabetes mellitus compared with routine medical management

Completed

• Conditions: Diabetes mellitus type 2; Nutritional, Metabolic, Endocrine; Non-insulin-dependent diabetes mellitus

• Registration Number: ISRCTN16466697
• Lead Sponsor: Riphah International University

Brief Summary

1. 2017 results of the effects of supervised structured aerobic exercise training program on fasting blood glucose level, plasma insulin level, glycemic control, and insulin resistance in type 2 diabetes mellitus. In https://www.ncbi.nlm.nih.gov/pubmed/28811774 (added 24/01/2019) 2. 2017 results of the effects of supervised structured aerobic exercise training program on high and low density lipoprotein in patients with type II diabetes mellitus. In https://www.ncbi.nlm.nih.gov/pubmed/28367180 (added 24/01/2019) 3. 2017 results of the effects of supervised structured aerobic exercise training program on interleukin-6, nitric oxide synthase-1, and cyclooxygenase-2 in type 2 diabetes mellitus. In https://www.ncbi.nlm.nih.gov/pubmed/28689524 (added 24/01/2019) 4. 2017 results of the effects of supervised structured aerobic exercise training programme on level of exertion, dyspnoea, VO2 max and body mass index in patients with type 2 diabetes mellitus. In https://www.ncbi.nlm.nih.gov/pubmed/29171557 (added 24/01/2019) 5. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/30129517 (added 24/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2016-06-30
• Study Start: 2016-12-12
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients with type 2 diabetes mellitus diagnosed as per WHO criteria
2. Established diagnosis of type 2 diabetes mellitus with 1 year history
3. Age 30-70
4. No other post-diabetic complications or comorbidity
5. No prior history of regular physical exercise

Exclusion Criteria

1. Patients with type 1 diabetes mellitus or pregnancy induced diabetes
2. Aged less than 30/more than 70
3. Patients with any other post-diabetic complications or comorbidity
4. Musculoskeletal, cardiopulmonary or neurological problems.
5. Smokers
6. Patients with type 2 diabetes mellitus with a history of regular exercise

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Insulin resistance, measured using the HOMA Method<br> 2. Glycemic control (HbA1c), measured using a kit<br> 3. Plasma insulin level, measured using a kit<br> 4. Fasting blood glucose level, estimated by glucometer<br> Measured at baseline and at the completion of 6 month (25 weeks) intervention.<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. LDL and HDL cholesterol, measured from blood by using kits<br> 2. Aerobic capacity (VO2 peak), measured by resting heart rate based method<br> 3. Body weight<br> 4. Body mass index (BMI)<br> 5. Level of exertion, measured using the Borge scale<br> 6. Dyspnea, measured by dyspnea index<br> 7. Blood pressure, measured by BP apparatus<br> 8. Post diabetic complications, measured by physical examination<br> 9. Inflammatory markers, measured by Human ELISA Kits<br> Measured at baseline and at the completion of 6 month (25 weeks) intervention.<br>