Prediction of neurological outcome after out of hospital cardiac arrest - a prospective observational study

Recruiting

• Conditions: I46.0; Cardiac arrest with successful resuscitation

• Registration Number: DRKS00033447
• Lead Sponsor: niversitätsklinikum Heidelberg, Klinik für Anästhesiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patients:
- Out-of-hospital cardiac arrest of any cause with resuscitation efforts by emergency medical services
- Consent by legal representatives and/or patient after regaining consciousness

Healthy subjects:
- Capacity to consent
- Consent by the subject
- Age =18 years

Exclusion Criteria

Patients:
- Prisoners
- Living will prohibit resuscitation and intensive care measures

Healthy test subjects:
- Condition after circulatory arrest
- Neurological deficit, defined as a previous stroke, cerebral hemorrhage, or known epilepsy
- Chronic renal insufficiency, regardless of the stage
- Illness from the psychiatric spectrum

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Do the whole blood transcriptome, organ-specific damage as determined by methylation-specific PCR, and peripheral immune cell composition at the time of cardiac arrest, 24 and 72 hours after ROSC, and at 30 days differ between subjects with good neurologic survival (CPC 1-2) and subjects with poor neurologic survival (CPC 3-4) at day 30 after OHCA?