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Clinical Trials/NCT06612125
NCT06612125
Recruiting
Not Applicable

Comparison of Positive Pressure Ventilation Strategies in Young Children Undergoing Laparoscopic Inguinal Hernia Repair With Laryngeal Mask Airway: A Prospective Randomized Study

Beni-Suef University1 site in 1 country78 target enrollmentOctober 1, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Ventilation Therapy; Complications
Sponsor
Beni-Suef University
Enrollment
78
Locations
1
Primary Endpoint
(PIP)
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV). VCV guarantees a target volume of ventilation using a constant flow, but may lead to high peak airway pressure (Ppeak) during the gas insufflation . In PCV mode, on the other hand,

Detailed Description

The laryngeal mask airway (LMA) provides a useful alternative for airway management during general anaesthesia. Inflation of the LMA cuff produces a low-pressure seal around the larynx, enabling positive pressure ventilation (PPV). The use of LMA as an airway management technique is common in the pediatric anesthesia because of its less irritating effect on the airways due to its location in the upper larynx. Now, the use of laryngeal mask instead of tracheal intubation for airway management has been achieved in day surgery, therefore, how to perform a respiratory management with a laryngeal mask is particularly important. In addition, mechanical ventilation is also a commonly used method of airway management in clinical practice. the ventilator will deliver a constant pressure by decelerating the flow. However, the ventilation volume varies according to the patient's respiratory mechanics . Pressure-controlled ventilation-volume guaranteed (PCV-VG) combines the advantages of both VCV and PCV, which delivers a stable ventilation volume using a decelerating flow pattern.

Registry
clinicaltrials.gov
Start Date
October 1, 2024
End Date
March 30, 2025
Last Updated
last year
Study Type
Interventional
Study Design
Sequential
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Mariana Soliman

egypt benisuef

Beni-Suef University

Eligibility Criteria

Inclusion Criteria

  • age between 1 and 5 years.
  • patient scheduled for laparoscopic inguinal hernia repair.
  • American Society of Anesthesiologists classification of physical status of I-II.

Exclusion Criteria

  • cardiopulmonary disease.
  • severe hepatorenal dysfunction.
  • history of upper respiratory tract infection 2 weeks before the operation.
  • overweight \[more than 20% of standard body weight\].
  • neuromuscular disease.
  • anticipated difficult airway.
  • hiatus hernia or gastroesophageal reflux disease.

Outcomes

Primary Outcomes

(PIP)

Time Frame: within one hour

peak inspiratory pressure

Pplat

Time Frame: within one hour

plateau airway pressure

(Cdyn)

Time Frame: within one hour

pulmonary dynamic compliance

(RAW

Time Frame: within one hour

airway resistance

VT

Time Frame: within one hour

exhaled tidal volume

EtCO2

Time Frame: within one hour

end-expiratory carbon dioxide

Vd/VT

Time Frame: within one hour

physiologic dead space over tidal volume

Secondary Outcomes

  • (MAP)(within one hour)
  • (HR)(within one hour)
  • postoperative respiratory adverse events(within 24 hour)

Study Sites (1)

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