A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
- Registration Number
- NCT04232553
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 778
- Participants must have completed study I6T-MC-AMAG (NCT02891226) or study I6T-MC-AMAM (NCT03926130)
- If female, participant must meet the contraception requirements
- Participants must not have developed a new condition, including cancer in the previous study (I6T-MC-AMAG or I6T-MC-AMAM) that would pose an unacceptable risk in the trial.
- Participants must not have any important infections including, but not limited to, hepatitis B, hepatitis C, HIV/AIDS, and active tuberculosis (TB) during either previous study.
Note: Participants with a history of active TB with documentation of treatment by the Centers for Disease Control (CDC) and/or World Health Organization (WHO) criteria prior to the originator study are not excluded from the study.
- Participants must not have a known hypersensitivity to any component of mirikizumab or have experienced acute systemic hypersensitivity event with previous study drug administration in the originating study that precludes mirikizumab therapy.
- Participation must not be pregnant, lactating, or planning to become pregnant while enrolled in the study or 16 weeks after receiving the last dose of study drug.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Mirikizumab IV and SC Mirikizumab Mirikizumab given intravenously (IV) and SC. Mirikizumab SC Mirikizumab Mirikizumab given subcutaneously (SC).
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Endoscopic Response Week 52 Endoscopic response based on Simple Endoscopic Score for Crohn's Disease (SES-CD) total score
Percentage of Participants Achieving Clinical Remission Week 52 Clinical remission based on Crohn's Disease Activity Index (CDAI)
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Endoscopic Remission Week 52 Endoscopic remission based on SES-CD total score
Percentage of Participants Achieving Clinical Response Week 52 Clinical response by patient-reported outcomes (PRO) based on stool frequency (SF) and abdominal pain (AP)
Change from Baseline in Fecal Calprotectin Baseline, Week 12 Change from baseline in fecal calprotectin
Change from Baseline on the Inflammatory Bowel Disease Questionnaire (IBDQ) Baseline to Week 52 Change from baseline on the IBDQ
Change from Baseline in C-Reactive Protein Baseline, Week 12 Change from baseline in c-reactive protein
Trial Locations
- Locations (321)
Zhongshan Hospital Affiliated to Xiamen University
🇨🇳Xiamen, Fujian, China
The First People's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Tongji Hospital Tongji Medical,Science & Technology
🇨🇳Wuhan, Hubei, China
Wuxi People's Hospital
🇨🇳Wuxi, Jiangsu, China
Klinički bolnički centar Osijek
🇭🇷Osijek, Croatia
Vojenská Nemocnice Brno
🇨🇿Brno, Brno-město, Czechia
Oblastni nemocnice Nachod
🇨🇿Nachod, Náchod, Czechia
Synexus Czech
🇨🇿Prague, Praha 2, Czechia
Fakultni Thomayerova nemocnice
🇨🇿Prague, Praha 4, Czechia
Siteworks GmbH - Lauterbach
🇩🇪Lauterbach, Hessen, Germany
Allgemeine Innere Medizin I
🇩🇪Kiel, Schleswig-Holstein, Germany
Soroka Medical Center
🇮🇱Be'er Sheva, HaDarom, Israel
Kiryu Kosei General Hospital
🇯🇵Kiryu, Gunma, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Chuo-ku, Sapporo-shi, Hokkaido, Japan
Tokushukai Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Ibaraki Prefectural Central Hospital
🇯🇵Kasama, Ibaraki, Japan
Ofuna Central Hospital
🇯🇵Kamakura, Kanagawa, Japan
Institute of Science Tokyo Hospital
🇯🇵Bunkyo, Tokyo, Japan
Okayama Saiseikai Outpatient Center Hospital
🇯🇵Okayama, Japan
Synexus - Wroclaw
🇵🇱Wroclaw, Dolnośląskie, Poland
Dc-Med
🇵🇱Świdnica, Dolnośląskie, Poland
ETG Zamość
🇵🇱Zamosc, Lubelskie, Poland
Digestive Health Specialists
🇺🇸Dothan, Alabama, United States
Care Access - Gilroy
🇺🇸Gilroy, California, United States
IHS Health Research
🇺🇸Kissimmee, Florida, United States
Ezy Medical Research
🇺🇸Miami, Florida, United States
Care Access - Orlando
🇺🇸Orlando, Florida, United States
Precision Clinical Research
🇺🇸Sunrise, Florida, United States
USF Health
🇺🇸Tampa, Florida, United States
Alliance Clinical Research of Tampa
🇺🇸Tampa, Florida, United States
Digestive Healthcare of Georgia
🇺🇸Atlanta, Georgia, United States
Ohio Gastroenterology
🇺🇸Columbus, Ohio, United States
First Surgical Hospital
🇺🇸Bellaire, Texas, United States
Coastal Digestive Health
🇦🇺Maroochydore, Queensland, Australia
Universitaetsklinikum Allgemeines Krankenhaus Wien
🇦🇹Vienna, Wien, Austria
Uniklinikum Salzburg
🇦🇹Salzburg, Austria
Imelda General Hospital
🇧🇪Bonheiden, Antwerpen, Belgium
Clínica Hepatogastro JK
🇧🇷São Paulo, Brazil
Private Practice - Dr. Stephane M. Gauthier
🇨🇦North Bay, Ontario, Canada
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
Chongqing General Hospital
🇨🇳Chongqing, Chongqing, China
WIP Warsaw IBD Point Profesor Kierkus
🇵🇱Warsaw, Mazowieckie, Poland
Private Practice - Dr. Korczowski Bartosz
🇵🇱Rzeszow, Podkarpackie, Poland
Centrum Medyczne MEDYK
🇵🇱Rzeszow, Podkarpackie, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Mazowieckie, Poland
Topolowa Medicenter
🇵🇱Krakow, Małopolskie, Poland
NZOZ Formed
🇵🇱Wadowice, Małopolskie, Poland
Gastromed S.R.L.
🇷🇴Constanța, Romania
Hacettepe Universite Hastaneleri
🇹🇷Ankara, Turkey
Antalya Egitim ve Arastırma Hastanesi
🇹🇷Antalya, Turkey
Mustafa Kemal Universitesi
🇹🇷Hatay, Turkey
Medicana Kadiköy Hastanesi
🇹🇷Istanbul, Turkey
Acbadem Kozyatagi Hospital
🇹🇷Istanbul, Turkey
City Clinical Hospital No. 2
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Medbud Clinic
🇺🇦Kyiv, Kyivska Oblast, Ukraine
VNMU
🇺🇦Vinnytsya, Vinnytska Oblast, Ukraine
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
🇺🇦Kyiv, Ukraine
Whipps Cross University Hospital
🇬🇧London, England, United Kingdom
Synexus Wales Clinical Research Centre
🇬🇧Cardiff, United Kingdom
Postgraduate Institute of Medical Education & Research
🇮🇳Chandigarh, India
PreventaMed
🇨🇿Olomouc, Czechia
Research Solutions of Arizona
🇺🇸Litchfield Park, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC
🇺🇸Phoenix, Arizona, United States
Newport Huntington Medical Group
🇺🇸Huntington Beach, California, United States
California Medical Research Associates
🇺🇸Northridge, California, United States
Connecticut Clinical Research Institute
🇺🇸Bristol, Connecticut, United States
Gastroenterology Consultants of Clearwater
🇺🇸Clearwater, Florida, United States
Clinical Research of West Florida, Inc. (Clearwater)
🇺🇸Clearwater, Florida, United States
Gastroenterology Associates of Pensacola, PA
🇺🇸Pensacola, Florida, United States
Gastrointestinal Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Grand Teton Research Group
🇺🇸Idaho Falls, Idaho, United States
Qualmedica Research, LLC
🇺🇸Evansville, Indiana, United States
Indiana University Health University Hospital
🇺🇸Indianapolis, Indiana, United States
Delta Research Partners
🇺🇸Monroe, Louisiana, United States
Capital Digestive Care - Chevy Chase
🇺🇸Chevy Chase, Maryland, United States
Woodholme Gastroenterology Associates - Glen Burnie
🇺🇸Glen Burnie, Maryland, United States
The Digestive Health Center of Michigan (DHCMI)
🇺🇸Chesterfield, Michigan, United States
Revive Research Institute, Inc.
🇺🇸Farmington Hills, Michigan, United States
MNGI Digestive Health - Plymouth Endoscopy Center & Clinic
🇺🇸Plymouth, Minnesota, United States
Washington University Medical School
🇺🇸Saint Louis, Missouri, United States
Care Access - Las Vegas
🇺🇸Las Vegas, Nevada, United States
Holy Name Medical Center
🇺🇸Teaneck, New Jersey, United States
Clinical & Translational Research Center (CTRC)
🇺🇸Chapel Hill, North Carolina, United States
Carolina Digestive Diseases and Endoscopy Center
🇺🇸Greenville, North Carolina, United States
Care Access - Kinston
🇺🇸Kinston, North Carolina, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Ohio State University
🇺🇸Hilliard, Ohio, United States
North Shore Gastroenterology & Endoscopy Centers
🇺🇸Westlake, Ohio, United States
The University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
University Gastroenterology
🇺🇸Providence, Rhode Island, United States
Gastroenterology Associates of Orangeburg
🇺🇸Orangeburg, South Carolina, United States
Gastroenterology Center Of The Midsouth
🇺🇸Cordova, Tennessee, United States
Baylor College of Medicine Medical Center
🇺🇸Houston, Texas, United States
West Texas Digestive Disease
🇺🇸Lubbock, Texas, United States
Southern Star Research Institute
🇺🇸San Antonio, Texas, United States
Tyler Research Institute
🇺🇸Tyler, Texas, United States
Care Access - Ogden
🇺🇸Ogden, Utah, United States
Care Access - Salt Lake City
🇺🇸Salt Lake City, Utah, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
Clinical Research Partners, LLC
🇺🇸Richmond, Virginia, United States
Tidewater Physicians Multispecialty Group Clinical Research
🇺🇸Williamsburg, Virginia, United States
Washington Gastroenterology - Bellevue
🇺🇸Bellevue, Washington, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
Washington Gastroenterology - Tacoma
🇺🇸Tacoma, Washington, United States
DOM Centro de Reumatología
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
St Vincent's Hospital
🇦🇺Sydney, New South Wales, Australia
Royal Brisbane and Women's Hospital
🇦🇺Brisbane, Queensland, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
Medizinische Universitaet Innsbruck
🇦🇹Innsbruck, Tirol, Austria
Université Libre de Bruxelles - Hôpital Erasme
🇧🇪Brussels, Bruxelles-Capitale, Région De, Belgium
UZ Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
UZ Leuven
🇧🇪Leuven, Vlaams-Brabant, Belgium
CLIAGEN Clínica de Atenção em Gastroenterologia, Especialidades e Nutrição
🇧🇷Salvador, Bahia, Brazil
L2IP - Instituto de Pesquisas Clínicas
🇧🇷Brasília, Distrito Federal, Brazil
Chronos Pesquisa Clínica
🇧🇷Brasília, Distrito Federal, Brazil
Hospital Felicio Rocho
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Fundação Universidade de Caxias do Sul (FUCS)
🇧🇷Caxias do sul, Rio Grande Do Sul, Brazil
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Moinhos de Vento
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Faculdade de Medicina da UNESP
🇧🇷Botucatu, São Paulo, Brazil
Centro de Pesquisa Sao Lucas
🇧🇷Campinas, São Paulo, Brazil
Praxis Pesquisa Medica
🇧🇷Santo Andre, São Paulo, Brazil
Pesquisare Saude
🇧🇷Santo André, São Paulo, Brazil
Centro Multidisciplinar de Estudos Clinicos
🇧🇷Sao Bernardo do Campo, São Paulo, Brazil
Hospital Sírio Libanês
🇧🇷Sao Paulo, São Paulo, Brazil
CPQuali Pesquisa Clínica
🇧🇷São Paulo, Brazil
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
🇧🇷São Paulo, Brazil
Gastroenterology and internal medicine research institute
🇨🇦Edmonton, Alberta, Canada
GIRI GI Research Institute - Vancouver
🇨🇦Vancouver, British Columbia, Canada
Private Practice - Dr. Bruce Musgrave
🇨🇦Kentville, Nova Scotia, Canada
Victoria Hospital
🇨🇦London, Ontario, Canada
The Sixth Affiliated Hospital of Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
The First Affiliated Hospital, Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
The Third Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The First People's Hospital of Changzhou
🇨🇳Changzhou, Jiangsu, China
Changzhou No.2 People's Hospital
🇨🇳Changzhou, Jiangsu, China
Jiangsu Province Hospital of Chinese Medicine
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Affiliated Hospital of Jiangsu University
🇨🇳Zhenjiang, Jiangsu, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
West China Hospital, Sichuan University
🇨🇳Cheng Du, Sichuan, China
First Affiliated Hospital of Kunming Medical University
🇨🇳Kunming, Yunnan, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Shanghai, China
The First Affiliated Hospital, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated hospital of Zhejiang University school of medicine
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
🇨🇳Wenzhou, Zhejiang, China
The First Affiliated Hospital Of Fujian Medical University
🇨🇳Fuzhou, China
Klinički bolnički centar Zagreb
🇭🇷Zagreb, Grad Zagreb, Croatia
Fakultni Nemocnice u sv. Anny v Brne
🇨🇿Brno, Brno-město, Czechia
Hepato-Gastroenterologie HK
🇨🇿Hradec Kralove, Hradec Králové, Czechia
MUDr. Gregar, s.r.o.
🇨🇿Olomouc, Olomoucký Kraj, Czechia
MUDr. Radka Koskova, s.r.o.
🇨🇿Ostrava, Ostrava Město, Czechia
Institut Klinicke a Experimentalni Mediciny
🇨🇿Praha, Praha 4, Czechia
AXON Clinical
🇨🇿Praha, Praha 5, Czechia
Fakultni nemocnice Motol
🇨🇿Praha, Praha 5, Czechia
ISCARE klinické centrum
🇨🇿Prague, Praha 9, Czechia
Nemocnice Tomase Bati ve Zline
🇨🇿Zlín, Zlínský Kraj, Czechia
Masarykova Nemocnice V Usti Nad Labem
🇨🇿Usti nad Labem, Ústí Nad Labem, Czechia
Gastroenterologische Praxis Balsiger, Seibold & Partner
🇨🇭Bern, Berne, Switzerland
Chu Saint Eloi
🇫🇷Montpellier, Languedoc-Roussillon, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
🇫🇷Vandoeuvre lès Nancy, Meurthe-et-Moselle, France
Centre Hospitalier Universitaire de Poitiers
🇫🇷Poitiers, Vienne, France
Siloah St. Trudpert Klinikum
🇩🇪Pforzheim, Baden-Württemberg, Germany
Universitaetsklinikum Wuerzburg
🇩🇪Wuerzburg, Bayern, Germany
Synexus Clinical Research GmbH
🇩🇪Frankfurt am Main, Hessen, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Niedersachsen, Germany
Knappschaftskrankenhaus Bottrop
🇩🇪Bottrop, Nordrhein-Westfalen, Germany
Gemeinschaftspraxis Jakobeit
🇩🇪Wipperfürth, Nordrhein-Westfalen, Germany
Studiengesellschaft BSF Unternehmergesellschaft
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
Synexus Leipzig Clinical Research Centre
🇩🇪Leipzig, Sachsen, Germany
RED-Institut GmbH
🇩🇪Oldenburg, Schleswig-Holstein, Germany
Tumorzentrum Nordthüringen Medizinisches Versorgungszentrum
🇩🇪Nordhausen, Thüringen, Germany
Synexus Magyarország Kft
🇭🇺Gyula, Békés, Hungary
Bugát Pál Kórház
🇭🇺Gyöngyös, Heves, Hungary
Szent Borbala Korhaz
🇭🇺Tatabánya, Komárom-Esztergom, Hungary
Jávorszky Ödön Kórház
🇭🇺Vác, Pest, Hungary
CLINFAN Szolgáltató Kft
🇭🇺Szekszárd, Tolna, Hungary
DRC Gyógyszervizsgáló Központ
🇭🇺Balatonfüred, Veszprém, Hungary
Clinexpert Kft.
🇭🇺Budapest, Hungary
SYNEXUS Magyarország Kft. Eü.
🇭🇺Budapest, Hungary
Pannónia Magánorvosi Centrum
🇭🇺Budapest, Hungary
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
🇭🇺Békéscsaba, Hungary
All India Institute of Medical Sciences
🇮🇳New Delhi, Delhi, India
Sir Ganga Ram Hospital
🇮🇳New Delhi, Delhi, India
Gujarat Hospital - Gastro & Vascular Centre
🇮🇳Surat, Gujarat, India
Grant Medical Foundation - Ruby Hall Clinic
🇮🇳Pune, Maharashtra, India
Dayanand Medical College and Hospital
🇮🇳Ludhiana, Punjab, India
SR Kalla Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Apollo Speciality Hospital - Teynampet
🇮🇳Chennai, Tamil Nadu, India
Sheba Medical Center
🇮🇱Ramat Gan, HaMerkaz, Israel
Kaplan Medical Center
🇮🇱Rehovot, HaMerkaz, Israel
Yitzhak Shamir Medical Center
🇮🇱Zerifin, HaMerkaz, Israel
Galilee Medical Center
🇮🇱Nahariya, HaTsafon, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Lombardia, Italy
IRCCS Policlinico San Donato
🇮🇹Milan, Milano, Italy
Ospedale Di Circolo
🇮🇹Rho, Milano, Italy
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Aomori, Japan
Tsujinaka Hospital - Kashiwanoha
🇯🇵Kashiwa, Chiba, Japan
Kitakyushu Municipal Medical Center
🇯🇵Kitakyusyu-shi, Fukoka, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Fukuoka, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Hokkaido, Japan
Hyogo College of Medicine
🇯🇵Nishinomiya, Hyogo, Japan
Mie University Hospital
🇯🇵Tsu, Mie, Japan
Takagi Clinic - Sendai
🇯🇵Sendai, Miyagi, Japan
Matsuda Hospital
🇯🇵Hamamatsu, Shizuoka, Japan
Kyorin University Hospital
🇯🇵Mitaka, Tokyo, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Shinjyuku-ku, Tokyo, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
Sameshima Hospital
🇯🇵Kagoshima, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
University Hospital,Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Tokyo Yamate Medical Center
🇯🇵Tokyo, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama, Japan
Yonsei University-Wonju Severance Christian Hospital
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Korea University Ansan Hospital
🇰🇷Ansan-si, Kyǒnggi-do, Korea, Republic of
Hanyang University Guri Hospital
🇰🇷Guri-si, Kyǒnggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon-si, Kyǒnggi-do, Korea, Republic of
Yeungnam Univeristy Medical Center
🇰🇷Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Haeundae-gu, Pusan-Kwangyǒkshi, Korea, Republic of
Chungang University Hospital
🇰🇷Dongjak-gu, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Daegu, Taegu-Kwangyǒkshi, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Deagu, Taegu-Kwangyǒkshi, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Jung-gu, Taegu-Kwangyǒkshi, Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital
🇰🇷Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of
Pauls Stradins Clinical Univeristy Hospital
🇱🇻Riga, Rīga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas
🇱🇹Kaunas, Lithuania
Christus Muguerza Hospital Sur
🇲🇽Monterrey, Nuevo León, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo León, Mexico
Centro de Alta Especialidad en Reumatologia e Investigación del Potosi,S.C
🇲🇽San Luis Potosi, San Luis Potosí, Mexico
Scientia Investigacion Clinica S.C.
🇲🇽Chihuahua, Mexico
Elisabeth-TweeSteden Ziekenhuis
🇳🇱Tilburg, Noord-Brabant, Netherlands
Amsterdam UMC, locatie VUmc
🇳🇱Amsterdam, Noord-Holland, Netherlands
Melita Medical
🇵🇱Wroclaw, Dolnośląskie, Poland
Reumatop
🇵🇱Wroclaw, Dolnośląskie, Poland
Centrum Medyczne "Medis" Manermed
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
ZOZ Gastromed
🇵🇱Lublin, Lubelskie, Poland
Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty
🇵🇱Bialystok, Podlaskie, Poland
Synexus Polska Gdansku
🇵🇱Gdansk, Pomorskie, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdyni
🇵🇱Gdynia, Pomorskie, Poland
Endoskopia Sp. z.o.o.
🇵🇱Sopot, Pomorskie, Poland
NZOZ TwojeZdrowie
🇵🇱Elblag, Warmińsko-mazurskie, Poland
Synexus Polska Sp. z o.o. Oddzial w Poznaniu
🇵🇱Poznan, Wielkopolskie, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Zachodniopomorskie, Poland
SONOMED Centrum Medyczne
🇵🇱Szczecin, Zachodniopomorskie, Poland
Synexus Polska Sp. z o.o. Oddzial w Czestochowie
🇵🇱Czestochowa, Śląskie, Poland
Synexus Polska - Katowicach
🇵🇱Katowice, Śląskie, Poland
Kiepury Clinic
🇵🇱Sosnowiec, Śląskie, Poland
Spitalul de Oncologie Monza
🇷🇴Bucharest, București, Romania
Delta Health Care
🇷🇴Bucharest, București, Romania
S.C. Centrul Medical Medicum SRL
🇷🇴Bucuresti, București, Romania
Spitalul Clinic Colentina
🇷🇴Bucuresti, București, Romania
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
🇷🇴Timisoara, Timiș, Romania
Poliklinika Agmu "Konsul'tativno-Diagnosticheskiy Tsentr"
🇷🇺Barnaul, Altayskiy Kray, Russian Federation
Scientific Centre of Reconstructive and Restorative Surgery
🇷🇺Irkutsk, Irkutskaya Oblast', Russian Federation
Karelia Republican Hospital V.A. Baranova
🇷🇺Petrozavodsk, Kareliya, Respublika, Russian Federation
SIH Kemerovo Regional Clinical Hosptial
🇷🇺Kemerovo, Kemerovskaya Oblast', Russian Federation
Olla-Med
🇷🇺Moscow, Moskva, Russian Federation
Nizhny Novgorod Regional Hospital N.A. Semashko
🇷🇺Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation
LLC "Medicine Center SibNovoMed"
🇷🇺Novosibirsk, Novosibirskaya Oblast', Russian Federation
Research Institute of Physiology and Fundamental Medicine
🇷🇺Novosibirsk, Novosibirskaya Oblast', Russian Federation
Clinic of Omsk State Medical University
🇷🇺Omsk, Omskaya Oblast', Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Rostovskaya Oblast', Russian Federation
Uludag Universitesi
🇹🇷Bursa, Turkey
NonState Healthcare Institution Central Clinical Hospital
🇷🇺Samara, Samarskaya Oblast', Russian Federation
LLC Medical Center Reavita Med SPb
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Balt Med Clinic
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Saint-Petersburg City Hospital of Saint Elizabeth
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Scientific research center ECO-security
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Saint Petersburg State Budgetary Healthcare Institution City Clinical Hospital No.31
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
First Pavlov State Medical University of Saint Petersburg
🇷🇺Saint-Petersburg, Sankt-Peterburg, Russian Federation
LLC MA New Hospital
🇷🇺Ekaterinburg, Sverdlovskaya Oblast', Russian Federation
Clinical Hospital Center Zvezdara
🇷🇸Belgrade, Beograd, Serbia
University Medical Center "Bezanijska kosa"
🇷🇸Belgrade, Beograd, Serbia
General Hospital "Djordje Joanovic"
🇷🇸Zrenjanin, Vojvodina, Serbia
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
🇸🇰Banska Bystrica, Banskobystrický Kraj, Slovakia
Cliniq s.r.o.
🇸🇰Bratislava, Bratislavský Kraj, Slovakia
Gastromedic
🇸🇰Nové Zámky, Nitriansky Kraj, Slovakia
Gastro LM
🇸🇰Presov, Prešovský Kraj, Slovakia
Endomed, s.r.o.
🇸🇰Vranov N. Toplou, Prešovský Kraj, Slovakia
Cantonal Hospital St.Gallen
🇨🇭St.Gallen, Sankt Gallen, Switzerland
Inselspital Bern
🇨🇭Berne, Switzerland
Eskisehir Osmangazi University
🇹🇷Eskisehir, Eskişehir, Turkey
Istanbul Universitesi Cerrahpasa
🇹🇷Istanbul- Fatih, İstanbul, Turkey
Dokuz Eylül Üniversitesi
🇹🇷Balcova, İzmir, Turkey
Kocaeli University Medical Faculty Hospital
🇹🇷Izmit, Kocaeli, Turkey
Ankara City Hospital
🇹🇷Ankara, Turkey
Gazi University Health Research and Application Center Gazi Hospital
🇹🇷Ankara, Turkey
Trakya University
🇹🇷Edirne, Turkey
Mersin University
🇹🇷Mersin, Turkey
Medical Center Family Medicine Clinic
🇺🇦Dnipro, Dnipropetrovska Oblast, Ukraine
Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council"
🇺🇦Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
🇺🇦Odesa, Odeska Oblast, Ukraine
Medical Clinical Investigational Center of Medical Center Health Clinic
🇺🇦Vinnytsia, Vinnytska Oblast, Ukraine
Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia Regio -T
🇺🇦Vinnytsya, Vinnytska Oblast, Ukraine
Communal Non-profit Enterprise "City Hospital #6" of Zaporizhzhia City Council
🇺🇦Zaporizhia, Zaporizka Oblast, Ukraine
University Hospital branch of Danylo Halytsky Lviv National Medical University (UH DHLNMU)
🇺🇦Lviv, Lvivska Oblast, Ukraine
City Clinical Hospital #1, Vinnitsya National Medical University
🇺🇦Vinnytsya, Vinnytska Oblast, Ukraine
Transcarpathian Regional Hospital im.Andriya Novak
🇺🇦Uzhgorod, Zakarpatska Oblast, Ukraine
Diacenter
🇺🇦Zaporizhzhia, Zaporizka Oblast, Ukraine
Chernivtsi Regional Clinical Hospital
🇺🇦Chernivtsi, Ukraine
Medical Center Ok!Clinic+
🇺🇦Kyiv, Ukraine
Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrainian Ra -T
🇺🇦Kyiv, Ukraine
Municipal non-profit enterprise of Kyiv Regional Council "Kyiv Regional Center for Rehabilitation Medicine"
🇺🇦Kyiv, Ukraine
Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"
🇺🇦Kyiv, Ukraine
Addenbrooke's Hospital
🇬🇧Cambridge, Cambridgeshire, United Kingdom