Comparison of the Upper Airway Patency by Dexmedetomidine and Propofol Used for Sedation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- The occurrence of upper airway obstruction
研究概览
简要总结
Under the hypothesis that dexmedetomidine sedation would result in less upper airway obstruction, we evaluated the occurrence of upper airway collapse or the requirement of airway intervention in patients with obstructive sleep apnea during dexmedetomidine or propofol sedation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgery under spinal anesthesia
- •Intraoperative sedation
- •American Society of Anesthesiology physical status 1 or 2
- •Apnea/hypopnea index 5-14/h in Watch-PAT 200 analysis
排除标准
- •Anatomical defects on upper respiratory tract
- •Psychotic disorder
- •Drug addition
- •Alcohol addition
- •body mass index ≥ 35 kg/m2
研究组 & 干预措施
Dexmedetomidine
Intraoperative sedation is performed by using dexmedetomidine.
干预措施: Dexmedetomidine (Drug)
Propofol
Intraoperative sedation is performed by using propofol
干预措施: Propofol (Drug)
结局指标
主要结局
The occurrence of upper airway obstruction
时间窗: During the sedation period, an average of 3 hours.
When end-tidal carbon dioxide was not detected in spite of the respiratory effort during the sedation period, the case will be regarded as the occurrence of upper airway obstruction.
次要结局
未报告次要终点
研究者
Hyo-Seok Na
Principal investigator
Seoul National University Bundang Hospital