COMPARATRIVE STUDY TO EVALUATE INTRAVENOUS DEXMEDETOMIDINE AND ESMOLOL FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Not yet recruiting

• Conditions: IN PATIENTS UNDERGOING GENERAL ANAESTHESIA WITH LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

• Registration Number: CTRI/2018/07/014846
• Lead Sponsor: DR AKSHAY KALIA

Brief Summary

**COMPARATIVE STUDY TO EVALUATE INTRAVENOUS DEXMEDETOMIDINE AND ESMOLOL FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION**

**Candidate:** Dr. Akshay Kalia

**Supervisor**:                                               **Co-Supervisor**:

  **Dr.Naresh Baghla                                    Dr. Gurpreet Singh**

Head of the Department                              Professor,

Dept. of Anaesthesiolgy,                           Dept. of Anaesthesiology

G.G.S. Medical College,                               G.G.S. Medical College,

Faridkot.                                                 Faridkot.

**INTRODUCTION :** Securing a patent airway is of paramount importance in the management of any safe anesthetic procedure and it is one of the primary goals of an anaesthesiologist during general anaesthesiaThough endotracheal intubation is a perfect airway device yet its placement isknown to evoke the stress response, predominantly in the form of tachycardia and systemic hypertension, exposing the patient to unwanted risk The topic of study will be selected because tachycardia and hypertension may getfurther enhanced in response, to laryngoscope and tracheal intubation, proven dangerous to cardiovascular disease patients.

**AIMS AND OBJECTIVES**The present study will be designed 1. to evaluate the effects of Intravenous Dexmedetomidine and esmolol  in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation. 2. to compare the effects of Intravenous Dexmedetomidine and esmolol  in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation

**MATERIALS AND METHODS :** The present study will be conducted in a randomized manner in the department of Anaesthesiology, GGS Medical College and hospital,Faridkot on 210 adults participants of ASA Grade I & II, aged 18-60 years, schedule to undergo elective surgery under general anaesthesia, will be  randomly allocated to either of the three study groups.GROUP C – will receive 20ml of 0.9% Normal saline infused over a period of 10 min and induction of anaesthesia will be done immediately.GROUP D – will receive Dexmedetomidine 1μ/kg intravenous diluted with 0.9%  normal saline to 20 ml infused over 10 min and induction of anaesthesia will be done immediately.GROUP E – will receive Esmolol 1.5mg/kg intravenous diluted  with 0.9% normal saline to 20ml  infused over 10 min  and induction of anaesthesia will be done immediately**.**

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-20
• Last Update Posted: 2018-10-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

• 1 American Society of Anaesthesiologists Grade I and II patients.
• 2 Patients scheduled for elective surgery under general anaesthesia.

Exclusion Criteria

American Society of Anaesthesiologists Grade 3 and 4 patients Pregnant patients Refusal of the patient.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HAEMODYNAMIC RESPONSE	TIME WILL BE NOTED BEFORE , DURING , AFTER 1, 2, 4, 6, 8 AND 10 MIN OF INTUBATION

Secondary Outcome Measures

Name	Time	Method
HAEMODYNAMIC OUTCOME	TIME WILL BE NOTED BEFORE , DURING , AFTER 1, 2, 4, 6, 8 AND 10 MIN OF INTUBATION

Trial Locations

Locations (1)

GURU GOBIND SINGH MEDICAL COLLEGE AND HOSPITAL; 🇮🇳 Faridkot, PUNJAB, India

GURU GOBIND SINGH MEDICAL COLLEGE AND HOSPITAL

🇮🇳Faridkot, PUNJAB, India

DR AKSHAY KALIA

Principal investigator

8264744236

akshaykalia91@gmail.com