Comparison of the efficacy of dual trigger HCG and GnRH agonist compared to HCG only in women with poor response undergoing with antagonist protocol
Not Applicable
Recruiting
- Conditions
- Condition 1: Decreased ovarian reserve. Condition 2: Infertility. Condition 3: Poor response to ovarian stimulation.Female infertility associated with anovulationFemale infertilityN97.0
- Registration Number
- IRCT20230506058097N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 152
Inclusion Criteria
Women of reproductive age (from 15 to 45) with poor ovarian response who have at least two of the following criteria according to the Bologna criteria: age greater than or equal to 40 years, history of poor response with a maximum number of three oocytes obtained after stimulation or abnormal ovarian reserve confirmed by one of the two AFC test less than or equal to 7 or AMH less than or equal to 1.2
In the absence of criteria for old age or abnormal ovarian reserve, if a woman has a history of two weak responses after maximal ovarian stimulation
Informed consent of clients to enter the research
Exclusion Criteria
Azospermia in the client's wife
Women with polycystic ovary syndrome
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of oocyte obtained. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: Observation (with microscope) and counting of eggs in the laboratory by an embryologist.;Chemical pregnancy. Timepoint: two weeks after embryo transfer. Method of measurement: Blood sampling, Measurement of BHCG Titer.;Clinical pregnancy. Timepoint: eight weeks after embryo transfer. Method of measurement: Ultrasound, visualization of the gestational sac and fetal heart.
- Secondary Outcome Measures
Name Time Method Abortion. Timepoint: any time before 20 weeks of gestation. Method of measurement: Removal of pregnancy products before week 20.