The difference in postprandial anabolic response between young and elderly, healthy volunteers.
- Conditions
- 10019654postprandial anabolic response10018424
- Registration Number
- NL-OMON48596
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 18
- Ability to provide informed consent
- 18-30 years or older than 65 years at the time of signing the informed consent
- Body mass index (BMI) 18.5- 25 kg/m2
- Caucasian men
- General good health as determined by medical history, physical examination
and blood chemistry by a physician.
- HOMA-IR index: * 2.0 (measured as fasting insulin (pmol/L) x fasting glucose
(mmol/L) / 135)
- Major illness in the past 3 months
- Use of any medication
- Gastro-intestinal disease that may influence bile acid signalling metabolism
- History of cholecystectomy or other bile duct abnormalities
- Tobacco smoking
- Drugs abuse
- Alcoholism (>3 units a day)
- Blood chemistry (fasted):
* Creatinine >120 µM
* Glucose * 5.6 mmol/L
* >2 times upper limit reference interval of the following: ASAT, ALAT, GGT, AP
- Strenuous exercise for at least 3 days prior to each study day, defined as
more than 1 hour of exercise per day.
- Hypersensitivity to substances in Nutridrink
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are postprandial bile metabolism expressed as<br /><br>concentration, area under the curve and inflammatory response as determined by<br /><br>the whole blood leukocyte counts and plasma cytokines. </p><br>
- Secondary Outcome Measures
Name Time Method <p>. To assess the effect of a MMT on:<br /><br>* Glucoregulatory and gut hormones<br /><br>* Lipid profiles<br /><br>* Resting energy expenditure<br /><br>* Appetite and satiety<br /><br>* Body composition<br /><br>* Micriobiome </p><br>