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临床试验/NCT02615613
NCT02615613已完成不适用

Effect of Food Acceptability on Appetite Hormones' Response in Normal Weight Male Subjects

American University of Beirut Medical Center0 个研究点目标入组 11 人开始时间: 2014年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
11
主要终点
Food acceptability score

研究概览

简要总结

30-40 healthy male subjects with a BMI between 18.5 and 24.9 kg/m2 will be tested for food preferences using a questionnaire with 141 different foods. Accordingly, a high acceptability/palatability food will be selected (average score of ≥ 7 on the 9-point hedonic scale). Two versions of the selected high palatability food will be devised by modifying it to yield the original high and the modified low acceptability versions. The two versions will differ only in palatability and will be equicaloric. Subjects who agree on the acceptability of the two versions of the food (11 subjects) will consume, at fasting, the two versions of the food in a cross over design over two sessions. Each session will include an acceptability test, using the 9-point hedonic scale, on three instances: after sampling a spoonful, eating the whole portion and after 240 min. The quantity consumed on each session will constitute 30% of the subject's resting energy expenditure. Moreover, fasting and postprandial hunger ratings and blood samples will be collected at time 0 and after 15, 30, 60, 120, 180 and 240 min of the food/meal's ingestion. The visual analogue scale will be used for huger ratings.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Gender: Male
  • Age: 18-50 years
  • Body Mass Index (BMI): 18.5-24.9 kg/m2
  • Stable body weight for at least three months before the study with absence of any form of dieting, food restriction or other abnormal eating behaviors (to minimize effect of weight change on ghrelin status)

排除标准

  • Substance abuse such as alcohol or drugs
  • Medical or psychological illness
  • Use of medications
  • Previous gastrointestinal surgery
  • History of weight fluctuation (weight loss of greater than 5% within the past 3 months)

结局指标

主要结局

Food acceptability score

时间窗: Two weeks

Ghrelin level

时间窗: Two weeks

次要结局

  • Glucose level(Two weeks)
  • Appetite score on the visual analogue scale(Two weeks)
  • Insulin level(2 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ammar Olabi

Associate Professor

American University of Beirut Medical Center

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