Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

Not Applicable

• Conditions: Healthy
• Interventions: Other: fast and exercise; Other: exercise

• Registration Number: NCT00978640
• Lead Sponsor: University of Aarhus

Brief Summary

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2009-09-16
• Study First Submitted QC: 2009-09-16
• Study First Posted: 2009-09-17
• Status Verified: 2012-06
• Primary Completion: 2012-06
• Study Completion: 2012-06
• Last Update Submitted: 2012-06-19
• Last Update Posted: 2012-06-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• healthy men
• Body mass index (BMI) 20-26
• age 18-45 years

Exclusion Criteria

• any kind of disease
• any use of medicine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
fasting and exercise	fast and exercise	36 h fast and 1 h ergometer cycling 50% VO2max
exercise	exercise	1 h ergometer cycling 50% VO2max

Primary Outcome Measures

Name	Time	Method
Sirt1 activity	60 min

Secondary Outcome Measures

Name	Time	Method
secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.	4 h

Trial Locations

Locations (1)

mikkel Holm Vendelbo; 🇩🇰 Århus, Jylland, Denmark