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Interest of the Pleth Variability Index in Neurosurgery

Not Applicable
Completed
Conditions
Intraoperative Monitoring
Hypovolemia
Fluid Challenge
Registration Number
NCT06624891
Lead Sponsor
National Institute of Neurology, Tunisia
Brief Summary

This clinical trial aims to study the interest of the Pleth Variability Index (PVI) to evaluate perioperative fluid responsiveness in neurosurgery in adults.

The main question it aims to answer is:

• Does the Pleth variability index predict fluid responsiveness in neurosurgery? Researchers will compare the Pleth variability index to dela PP to see if it predicts fluid responsiveness in neurosurgery.

Once participants give their consent, they will be randomly assigned to one of two groups. In one group, fluid responsiveness will be monitored using the Pleth Variability Index, while in the other group, it will be monitored using delta PP.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
70
Inclusion Criteria
  1. Patients proposed for intracranial surgery
  2. Must be aged 18 and over
  3. Must be classified as ASA I, ASA II, and ASA III according to the American Society of Anesthesiologists classification
Exclusion Criteria
  1. Non-consenting patients
  2. Patients classified ASA IV or higher
  3. Cardiac arrhythmia
  4. Heart disease with left ventricular ejection fraction less than 45%
  5. Obesity with a BMI greater than 40 Kg/m2.
  6. Peripheral vascular disease
  7. Severe lung disease
  8. End-stage renal disease
  9. Intraoperative cardiac arrhythmia
  10. The occurrence of cardiac arrest
  11. The occurrence of hemorrhagic shock
  12. Intraoperative use of low tidal volumes or high respiratory rates.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Value of PVI in fluid responsiveness in neurosurgerychanfe of PVI value from baseline to a value more than 14% and untill the end of surgery

Investigate the value of the plethysmographic variability index (PVI) in assessing the response to perioperative vascular filling in neurosurgery.

Secondary Outcome Measures
NameTimeMethod
Amount of fluids administered intraoperativelyduring the surgery
Renal, metabolic and hydroelectrolytic repercussions.up to the first 24 hours postoperatively
Length of postoperative stayup to hospital discharge, an average of 4 days
Incidence of post-operative complicationsup to hospital discharge, an average of 4 days

Trial Locations

Locations (1)

National Institute of Neurologie Mongi Ben-Hamida

🇹🇳

Tunis, Tunisia

National Institute of Neurologie Mongi Ben-Hamida
🇹🇳Tunis, Tunisia

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