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A Safety Study of Human Cord Blood Derived, Culture Expanded Natural Killer Cell (PNK-007) Infusion With Subcutaneous Recombinant Human IL-2 (rhIL-2) in Adults With Relapsed and/or Refractory Acute Myeloid Leukemia (AML)

Phase 1
Terminated
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2016-05-24
Last Posted Date
2020-07-22
Lead Sponsor
Celularity Incorporated
Target Recruit Count
10
Registration Number
NCT02781467
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

🇺🇸

University of Minnesota, Minneapolis, Minnesota, United States

🇺🇸

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States

and more 4 locations

An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)

Phase 2
Completed
Conditions
Myelodysplastic Syndromes
Leukemia, Myeloid, Acute
Interventions
Biological: Durvalumab
First Posted Date
2016-05-18
Last Posted Date
2023-02-28
Lead Sponsor
Celgene
Target Recruit Count
213
Registration Number
NCT02775903
Locations
🇺🇸

Yale Cancer Center, New Haven, Connecticut, United States

🇺🇸

Georgetown University Hospital, Washington, District of Columbia, United States

🇺🇸

University of Florida, Gainesville, Florida, United States

and more 100 locations

Clinical Trial of Oral Ciprofloxacin and Etoposide in Subjects With Resistant Acute Myeloid Leukemia (AML)(UF-AML-CE-101)

Phase 1
Terminated
Conditions
Leukemia
Acute Myelogenous Leukemia
Acute Myeloid Leukemia
Interventions
First Posted Date
2016-05-16
Last Posted Date
2022-08-05
Lead Sponsor
University of Florida
Target Recruit Count
11
Registration Number
NCT02773732
Locations
🇺🇸

UF Health Shands Cancer Hospital, Gainesville, Florida, United States

A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy

Phase 3
Completed
Conditions
Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Interventions
First Posted Date
2016-04-26
Last Posted Date
2024-12-27
Lead Sponsor
Astellas Pharma Global Development, Inc.
Target Recruit Count
183
Registration Number
NCT02752035
Locations
🇺🇸

UCLA David Geffen School of Medicine, Los Angeles, California, United States

🇺🇸

University of California, Irvine Medical Center, Orange, California, United States

🇺🇸

Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, United States

and more 108 locations

Study of IRX5183 in Relapsed and Refractory Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

Phase 1
Terminated
Conditions
Chronic Myelomonocytic Leukemia (CMML)
Myelodysplastic Syndrome (MDS)
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2016-04-25
Last Posted Date
2019-04-22
Lead Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Target Recruit Count
13
Registration Number
NCT02749708
Locations
🇺🇸

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Phase 1
Completed
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2016-03-22
Last Posted Date
2021-08-31
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
62
Registration Number
NCT02715011

A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Phase 1
Active, not recruiting
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2016-02-09
Last Posted Date
2025-04-23
Lead Sponsor
Celgene
Target Recruit Count
130
Registration Number
NCT02677922
Locations
🇺🇸

Local Institution - 105, Duarte, California, United States

🇺🇸

Local Institution - 107, New Haven, Connecticut, United States

🇺🇸

Local Institution - 108, Chicago, Illinois, United States

and more 46 locations

Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML)

Phase 3
Completed
Conditions
Acute Myeloid Leukemia
Leukemia
Interventions
Drug: Chemotherapy
Drug: Placebo
First Posted Date
2016-01-29
Last Posted Date
2024-08-06
Lead Sponsor
Daiichi Sankyo
Target Recruit Count
539
Registration Number
NCT02668653
Locations
🇺🇸

University of Florida (UF) Health Shands Hospital, Gainesville, Florida, United States

🇺🇸

The University of Chicago Medical Center, Chicago, Illinois, United States

🇺🇸

Franciscan St. Francis Health Indianapolis, Indianapolis, Indiana, United States

and more 240 locations

Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia

Phase 2
Completed
Conditions
Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Acute Myeloid Leukemia With Multilineage Dysplasia
Myeloid Sarcoma
Secondary Acute Myeloid Leukemia
Therapy-Related Acute Myeloid Leukemia
Therapy-Related Myelodysplastic Syndrome
Interventions
First Posted Date
2016-01-18
Last Posted Date
2025-04-15
Lead Sponsor
Vanderbilt-Ingram Cancer Center
Target Recruit Count
42
Registration Number
NCT02658487
Locations
🇺🇸

Yale University, New Haven, Connecticut, United States

🇺🇸

Medical University of South Carolina Hollings Cancer Center, Charleston, South Carolina, United States

🇺🇸

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States

Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants with Relapsed/Refractory Cancer Indications

Phase 1
Completed
Conditions
Relapsed/Refractory Multiple Myeloma (RRMM)
Metastatic Colorectal Cancer (mCRC)
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Higher-Risk Myelodysplastic Syndrome (HR-MDS)
Newly Diagnosed Intermediate/High-Risk MDS
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2016-01-07
Last Posted Date
2025-03-19
Lead Sponsor
Karyopharm Therapeutics Inc
Target Recruit Count
277
Registration Number
NCT02649790
Locations
🇺🇸

David Geffen School of Medicine at UCLA, Los Angeles, California, United States

🇺🇸

Oncology Institute of Hope and Innovation, Pasadena, California, United States

🇺🇸

Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United States

and more 43 locations

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