Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
-

Pre-operative Ketorolac Administration Has no Pre-emptive Analgesic Effect Following Total Abdominal Hysterectomy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-12-30
Last Posted Date
2016-01-05
Lead Sponsor
Hospital Arquitecto Marcide
Target Recruit Count
48
Registration Number
NCT02642718
Locations
🇪🇸

Complexo Hospitalario Arquitecto Marcide-Prof. Novoa Santos, Ferrol, A Coruña, Spain

🇬🇧

Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom

Ketorol Gel in Gonarthrosis and Low Back Pain

First Posted Date
2015-12-23
Last Posted Date
2017-03-13
Lead Sponsor
Dr. Reddy's Laboratories Limited
Target Recruit Count
240
Registration Number
NCT02638831

Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain

First Posted Date
2015-11-25
Last Posted Date
2016-09-20
Lead Sponsor
Azad University of Medical Sciences
Target Recruit Count
66
Registration Number
NCT02614118
Locations
🇮🇷

Dental Branch, AZad UMS, Tehran, Iran, Islamic Republic of

Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections

First Posted Date
2015-11-23
Last Posted Date
2016-10-13
Lead Sponsor
St. Luke's Hospital, Pennsylvania
Target Recruit Count
448
Registration Number
NCT02612272
Locations
🇺🇸

St Luke's Health and University Network, Bethlehem, Pennsylvania, United States

Betamethasone Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis

Phase 4
Active, not recruiting
Conditions
Interventions
First Posted Date
2015-11-13
Last Posted Date
2024-04-02
Lead Sponsor
OrthoCarolina Research Institute, Inc.
Target Recruit Count
64
Registration Number
NCT02604537
Locations
🇺🇸

OrthoCarolina, Charlotte, North Carolina, United States

Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection

First Posted Date
2015-11-11
Last Posted Date
2016-09-20
Lead Sponsor
Azad University of Medical Sciences
Target Recruit Count
60
Registration Number
NCT02601911
Locations
🇮🇷

Dental Branch, AZad UMS, Tehran, Iran, Islamic Republic of

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

First Posted Date
2015-10-07
Last Posted Date
2022-03-04
Lead Sponsor
Virginia Commonwealth University
Target Recruit Count
64
Registration Number
NCT02570503
Locations
🇺🇸

Virginia Commonwealth University, Richmond, Virginia, United States

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

First Posted Date
2015-09-03
Last Posted Date
2016-11-15
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
135
Registration Number
NCT02540070
Locations
🇨🇦

University Hospital, London Health Sciences Centre, London, Ontario, Canada

Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block

First Posted Date
2015-08-31
Last Posted Date
2015-09-02
Lead Sponsor
Nahid Mohammadzadeh Akhlaghi
Target Recruit Count
40
Registration Number
NCT02536430
Locations
🇮🇷

Dental Branch, AZad UMS, Tehran, Iran, Islamic Republic of

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