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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Sprix for Postoperative Pain Control Following Gynecologic Surgery

Phase 4
Withdrawn
Conditions
Urinary Incontinence , Stress
Pelvic Organ Prolapse
Post Operative Pain Control
Narcotic Use
Surgery
Interventions
First Posted Date
2020-06-24
Last Posted Date
2022-07-29
Lead Sponsor
University of Louisville
Registration Number
NCT04444830
Locations
🇺🇸

University of Louisville Hospital, Louisville, Kentucky, United States

Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Phase 2
Completed
Conditions
Arthritis Knee
Arthritis of Hip
Interventions
First Posted Date
2020-06-22
Last Posted Date
2020-06-22
Lead Sponsor
Saint Alphonsus Regional Medical Center
Target Recruit Count
120
Registration Number
NCT04441112
Locations
🇺🇸

Saint Alphonsus Regional Medical Center, Boise, Idaho, United States

Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use

Phase 1
Completed
Conditions
Breast Reduction
Breast Reconstruction
Interventions
First Posted Date
2020-06-19
Last Posted Date
2023-02-10
Lead Sponsor
Carilion Clinic
Target Recruit Count
183
Registration Number
NCT04439396
Locations
🇺🇸

James T. Thompson, Roanoke, Virginia, United States

Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy

Phase 3
Completed
Conditions
Pain, Postoperative
Interventions
Procedure: Paracervical block with ropivacaine
Procedure: Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites
First Posted Date
2020-06-11
Last Posted Date
2023-08-01
Lead Sponsor
State University of New York at Buffalo
Target Recruit Count
68
Registration Number
NCT04429022
Locations
🇺🇸

Millard Fillmore Suburban Hospital, Williamsville, New York, United States

Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain

Phase 4
Conditions
Pain
Supratentorial Brain Tumor
Interventions
First Posted Date
2020-05-08
Last Posted Date
2020-09-09
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
40
Registration Number
NCT04380298

Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

Phase 1
Withdrawn
Conditions
Chronic Migraine
Cluster Headache
Trigeminal Neuralgia
Interventions
First Posted Date
2020-04-20
Last Posted Date
2020-08-04
Lead Sponsor
Weill Medical College of Cornell University
Registration Number
NCT04353505
Locations
🇺🇸

Weill Cornell Medicine, New York, New York, United States

Omidria and Dexycu, or Omidria and Dextenza Compared to Topical Prednisolone Acetate 1% Following Cataract Surgery

Phase 4
Completed
Conditions
Cataract Surgery
Interventions
First Posted Date
2020-03-20
Last Posted Date
2023-06-15
Lead Sponsor
Silverstein Eye Centers
Target Recruit Count
15
Registration Number
NCT04316936
Locations
🇺🇸

Silverstein Eye Centers, Kansas City, Missouri, United States

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Phase 2
Recruiting
Conditions
Acute Pancreatitis
Interventions
Drug: Opioid
First Posted Date
2020-03-02
Last Posted Date
2024-02-14
Lead Sponsor
Boston Children's Hospital
Target Recruit Count
50
Registration Number
NCT04291599
Locations
🇺🇸

Boston Children's Hospital, Boston, Massachusetts, United States

Ketorolac in Acute Pancreatitis

Phase 4
Conditions
Acute Pancreatitis
Interventions
First Posted Date
2020-02-24
Last Posted Date
2020-12-08
Lead Sponsor
University of Cincinnati
Target Recruit Count
60
Registration Number
NCT04282200
Locations
🇺🇸

University of Cincinnati Medical Center, Cincinnati, Ohio, United States

Multimodal Pain Study in Free Flap Patients

Phase 4
Completed
Conditions
Analgesia
Head and Neck Cancer
Interventions
First Posted Date
2020-01-29
Last Posted Date
2023-08-18
Lead Sponsor
University of Kansas Medical Center
Target Recruit Count
30
Registration Number
NCT04246697
Locations
🇺🇸

University of Kansas Medical Center, Kansas City, Kansas, United States

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