Ketamine

Generic Name
Ketamine
Brand Names
Ketalar
Drug Type
Small Molecule
Chemical Formula
C13H16ClNO
CAS Number
6740-88-1
Unique Ingredient Identifier
690G0D6V8H
Background

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication

Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions
-
Associated Therapies
General Anesthesia, Induction and Maintenance of General Anesthesia
Clinical Trials
Related News

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

Phase 4
Recruiting
Conditions
Dissociation
Pain, Acute
Interventions
Drug: Ketamine
First Posted Date
2022-08-29
Last Posted Date
2024-07-16
Lead Sponsor
Summa Health System
Target Recruit Count
48
Registration Number
NCT05518877
Locations
🇺🇸

Summa Health System, Akron, Ohio, United States

Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001

Phase 2
Completed
Conditions
Pain
Interventions
Drug: CT001
Drug: Placebo
Drug: Sufentanil
Drug: Ketamine
First Posted Date
2022-08-19
Last Posted Date
2023-10-18
Lead Sponsor
Cessatech A/S
Target Recruit Count
220
Registration Number
NCT05508594
Locations
🇩🇰

DanTrials, Copenhagen, NV, Denmark

The Effects of Sedatives on Tobacco Use Disorder Version 2

First Posted Date
2022-08-18
Last Posted Date
2024-07-08
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
52
Registration Number
NCT05505630
Locations
🇺🇸

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Comparison Of Dexmedetomidine & Ketamine For Control Of Shivering In Vaginal Hysterectomy Under Spinal Anesthesia

Phase 3
Conditions
Chills
Interventions
Drug: Dexmedetomidine
Drug: Ketamine
First Posted Date
2022-08-01
Last Posted Date
2022-08-01
Lead Sponsor
Hamdard University
Target Recruit Count
104
Registration Number
NCT05481281

Observational Study of Ketamine Infusions for the Treatment of Chronic Pain

Conditions
Chronic Pain
Interventions
Drug: Ketamine
First Posted Date
2022-07-27
Last Posted Date
2024-05-16
Lead Sponsor
Theresa Lii
Target Recruit Count
100
Registration Number
NCT05477004
Locations
🇺🇸

Stanford University, Stanford, California, United States

The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

Not Applicable
Completed
Conditions
Ketamine-Induced Mood Disorder
Interventions
Drug: Ketamine
First Posted Date
2022-07-26
Last Posted Date
2023-05-24
Lead Sponsor
Fayoum University Hospital
Target Recruit Count
90
Registration Number
NCT05474183
Locations
🇪🇬

Fayoum University hospital, Fayoum, Faiyum Governorate, Egypt

Auditory MMN EEG in TRD in Response to Ketamine

First Posted Date
2022-07-19
Last Posted Date
2023-11-29
Lead Sponsor
Unity Health Toronto
Target Recruit Count
30
Registration Number
NCT05464264
Locations
🇨🇦

St. Michael's Hospital, Toronto, Ontario, Canada

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

Phase 4
Recruiting
Conditions
Major Depressive Disorder
Interventions
Drug: Ketamine
Drug: Esketamine
First Posted Date
2022-07-08
Last Posted Date
2023-01-25
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
100
Registration Number
NCT05450432
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

Caudal Ketamine-bupivacaine More Effective Than Bupivacaine-saline

Phase 1
Completed
Conditions
Pediatric Surgery
Surgery
Interventions
Drug: Ketamine
First Posted Date
2022-07-05
Last Posted Date
2022-09-10
Lead Sponsor
Egymedicalpedia
Target Recruit Count
60
Registration Number
NCT05444036
Locations
🇪🇬

October 6 University Hospital, Giza, CAiro, Egypt

Analgosedation for Elective Colonoscopy

Phase 1
Completed
Conditions
Pain
Side Effect
Interventions
Drug: Ketamine
First Posted Date
2022-06-16
Last Posted Date
2022-06-21
Lead Sponsor
Cantonal Hospital Zenica
Target Recruit Count
90
Registration Number
NCT05421962
Locations
🇧🇦

Cantonal Hospital, Zenica, Bosnia and Herzegovina

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