Ketamine

Generic Name
Ketamine
Brand Names
Ketalar
Drug Type
Small Molecule
Chemical Formula
C13H16ClNO
CAS Number
6740-88-1
Unique Ingredient Identifier
690G0D6V8H
Background

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication

Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions
-
Associated Therapies
General Anesthesia, Induction and Maintenance of General Anesthesia
Clinical Trials
Related News

Axillary Approach to Brachial Plexus Blockade Using Ketamine, Regional Versus Intravenous Administration

First Posted Date
2022-03-28
Last Posted Date
2022-03-28
Lead Sponsor
National and Kapodistrian University of Athens
Target Recruit Count
81
Registration Number
NCT05297422
Locations
🇬🇷

National and Kapodistrian University of Athens, Athens, Attiki, Greece

Ketamine and Epigenetic Aging

Phase 2
Recruiting
Conditions
Post Traumatic Stress Disorder
Depression
Interventions
Drug: Ketamine
First Posted Date
2022-03-24
Last Posted Date
2022-09-08
Lead Sponsor
TruDiagnostic
Target Recruit Count
20
Registration Number
NCT05294835
Locations
🇺🇸

Wild Health, Lexington, Kentucky, United States

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

First Posted Date
2022-03-15
Last Posted Date
2024-01-24
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
70
Registration Number
NCT05279898
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Randomized Trial of Sedative Choice for Intubation

Phase 4
Recruiting
Conditions
Acute Respiratory Failure
Interventions
Drug: Ketamine
Drug: Etomidate
First Posted Date
2022-03-14
Last Posted Date
2024-10-04
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
2364
Registration Number
NCT05277896
Locations
🇺🇸

UAB Hospital, Birmingham, Alabama, United States

🇺🇸

University of Colorado Denver, Aurora, Colorado, United States

🇺🇸

Denver Health Medical Center, Denver, Colorado, United States

and more 3 locations

Ketamine and Kidney Injury in Cardiac Surgery

Phase 4
Recruiting
Conditions
Cardiac Surgery
Interventions
Drug: Ketamine
Drug: Propofol
First Posted Date
2022-03-07
Last Posted Date
2024-01-12
Lead Sponsor
Mayo Clinic
Target Recruit Count
200
Registration Number
NCT05268562
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic Density Spectrum Array Analysis

First Posted Date
2022-02-25
Last Posted Date
2022-08-17
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
90
Registration Number
NCT05256264
Locations
🇨🇳

Taipei Veterans General Hospital, Taipei, Beitou, Taiwan

Naturalistic Study of Ketamine in the Treatment of Depression

First Posted Date
2022-02-21
Last Posted Date
2023-09-25
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
90
Registration Number
NCT05249309
Locations
🇧🇷

Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul, Brazil

🇧🇷

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil

Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial

Phase 3
Completed
Conditions
Postoperative Depression
Interventions
Drug: Normal saline
Drug: Ketamine
First Posted Date
2022-02-10
Last Posted Date
2024-04-10
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
32
Registration Number
NCT05233566
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post-traumatic Acute Pain in the Emergency Department ( INVESCK )

Phase 2
Recruiting
Conditions
Acute Pain
Interventions
Drug: Ketamine
First Posted Date
2022-02-08
Last Posted Date
2023-05-15
Lead Sponsor
University of Monastir
Target Recruit Count
1000
Registration Number
NCT05229055
Locations
🇹🇳

university of Monastir, Monastir, Tunisia

The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study

Phase 1
Recruiting
Conditions
Endometriosis
Post Operative Pain
Interventions
Drug: Placebo
Drug: Ketamine
First Posted Date
2022-02-08
Last Posted Date
2023-12-13
Lead Sponsor
NYU Langone Health
Target Recruit Count
30
Registration Number
NCT05229653
Locations
🇺🇸

NYU Langone Health, New York, New York, United States

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