Esomeprazole
- Generic Name
- Esomeprazole
- Brand Names
- Nexium, Vimovo, Nexium Control
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19N3O3S
- CAS Number
- 119141-88-7
- Unique Ingredient Identifier
- N3PA6559FT
- Background
Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison ...
- Indication
Esomeprazole is indicated for the treatment of acid-reflux disorders including healing and maintenance of erosive esophagitis, and symptomatic gastroesophageal reflux disease (GERD), peptic ulcer disease, H. pylori eradication, prevention of gastrointestinal bleeds with NSAID use, and for the long-term treatment of pathological hypersecretory conditions incl...
- Associated Conditions
- Duodenal Ulcer, Erosive Esophagitis, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Stress Ulcers, Upper Gastrointestinal Hemorrhage, Zollinger-Ellison Syndrome, Acute benign gastric ulcers, Develop NSAID-induced gastric ulcers, Maintenance of healing Erosive esophagitis, Postendoscopy Bleeding
- Associated Therapies
- -
A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection
- Conditions
- Interventions
- First Posted Date
- 2019-12-13
- Last Posted Date
- 2023-09-07
- Lead Sponsor
- Takeda
- Target Recruit Count
- 510
- Registration Number
- NCT04198363
- Locations
- 🇨🇳
The First People's Hospital of Foshan, Foshan, Guangdong, China
🇨🇳Friendship Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳Peking University Third Hospital, Beijing, Beijing, China
A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy Volunteers
- First Posted Date
- 2019-11-07
- Last Posted Date
- 2021-03-16
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 16
- Registration Number
- NCT04156646
- Locations
- 🇺🇸
PRA International Clinical Pharmacology Center (EDS US Clinic), Lenexa, Kansas, United States
A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy Adults
- First Posted Date
- 2019-10-29
- Last Posted Date
- 2020-03-04
- Lead Sponsor
- Assembly Biosciences
- Target Recruit Count
- 80
- Registration Number
- NCT04142762
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
Assess the Drug Interactions of BBT-877 and Midazolam, Itraconazole, and Esomeprazole in Healthy Adult Subjects
- Conditions
- Interventions
- First Posted Date
- 2019-10-25
- Last Posted Date
- 2020-01-18
- Lead Sponsor
- Bridge Biotherapeutics, Inc.
- Target Recruit Count
- 48
- Registration Number
- NCT04138836
- Locations
- 🇺🇸
Celerion, Lincoln, Nebraska, United States
High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment
- Conditions
- Interventions
- First Posted Date
- 2019-07-18
- Last Posted Date
- 2021-09-28
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 306
- Registration Number
- NCT04024527
- Locations
- 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
A Study of Esomeprazole in Children With Autism
- First Posted Date
- 2019-03-07
- Last Posted Date
- 2024-02-16
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 25
- Registration Number
- NCT03866668
- Locations
- 🇺🇸
Stanford University School of Medicine, Stanford, California, United States
A Trial to Evaluate the Effect of the Proton Pump Inhibitor Esomeprazole on the Single-dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants
- First Posted Date
- 2019-02-21
- Last Posted Date
- 2021-06-15
- Lead Sponsor
- Millennium Pharmaceuticals, Inc.
- Target Recruit Count
- 12
- Registration Number
- NCT03849690
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
- Conditions
- Interventions
- First Posted Date
- 2018-11-05
- Last Posted Date
- 2018-11-05
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 60
- Registration Number
- NCT03730766
- Locations
- 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
Esomeprazole for the Prevention of Preeclampsia
- First Posted Date
- 2018-10-24
- Last Posted Date
- 2019-01-10
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 1000
- Registration Number
- NCT03717740
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Metformin and Esomeprazole in Treatment of Early Onset Preeclampsia
- First Posted Date
- 2018-10-24
- Last Posted Date
- 2019-01-10
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT03717701
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Drug Development Updates
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