Cyclobenzaprine
- Generic Name
- Cyclobenzaprine
- Brand Names
- Amrix, Fexmid, Flexeril
- Drug Type
- Small Molecule
- Chemical Formula
- C20H21N
- CAS Number
- 303-53-7
- Unique Ingredient Identifier
- 69O5WQQ5TI
- Background
Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from Amitriptyline by only a single double bond. Since its approval, it has remained relatively popular...
- Indication
用于缓解与急性疼痛的肌肉骨骼疾病相关的肌肉痉挛（作为休息和物理治疗的辅助药）。但环苯扎林对脑、脊髓疾病或儿童脑性瘫痪引起的痉挛无效。
- Associated Conditions
- Muscle Spasms
- Associated Therapies
- -
Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study
- First Posted Date
- 2021-02-25
- Last Posted Date
- 2023-04-27
- Lead Sponsor
- Prisma Health-Midlands
- Target Recruit Count
- 72
- Registration Number
- NCT04771741
- Locations
- 🇺🇸
Prisma Health Midlands, Columbia, South Carolina, United States
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Conditions
- Interventions
- Drug: Tranexamic acid (TXA)Drug: HydrocodoneDrug: labetalolDrug: metforminDrug: nifedipineDrug: oxycodoneDrug: clindamycinDrug: azithromycinDrug: escitalopramDrug: sertralineDrug: CiprofloxacinDrug: ondansetronDrug: DoxycyclineDrug: LevofloxacinDrug: MethylphenidateDrug: CitalopramDrug: SumatriptanDrug: CyclobenzaprineDrug: FurosemideDrug: RosuvastatinDrug: GabapentinDrug: HydrochlorothiazideDrug: HydroxyureaDrug: TrazodoneDrug: TopiramateDrug: ValganciclovirDrug: RemdesivirDrug: VenlafaxineDrug: VerapamilDrug: FluvoxamineDrug: AnakinraDrug: TocilizumabDrug: AmoxicillinDrug: BupropionDrug: BuprenorphineDrug: LevetiracetamDrug: ParoxetineDrug: Duloxetine
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- Duke University
- Target Recruit Count
- 1600
- Registration Number
- NCT03511118
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸Loma Linda University Health, Loma Linda, California, United States
Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction
- Conditions
- Interventions
- First Posted Date
- 2017-04-25
- Last Posted Date
- 2023-02-09
- Lead Sponsor
- Apsen Farmaceutica S.A.
- Target Recruit Count
- 140
- Registration Number
- NCT03127592
- Locations
- 🇧🇷
Azidus Brasil Pesquisa Científica e Desenvolvimento Ltda., Valinhos, São Paulo, Brazil
Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine in Osteomuscular Treatment
- Conditions
- Interventions
- First Posted Date
- 2017-01-19
- Last Posted Date
- 2021-02-24
- Lead Sponsor
- EMS
- Target Recruit Count
- 416
- Registration Number
- NCT03025113
- Locations
- 🇧🇷
Allegisa, Campinas, São Paulo, Brazil
Cyclobenzaprine in Muscle Cramps With Liver Cirrhosis
- First Posted Date
- 2015-12-30
- Last Posted Date
- 2018-01-03
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 200
- Registration Number
- NCT02642861
- Locations
- 🇪🇬
Tanta university - faculty of medicine, Tanta, Egypt
Pilot Study of Cyclobenzaprine for Treatment of Sleep Disturbance in Aromatase Inhibitor-treated Breast Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2013-08-13
- Last Posted Date
- 2016-04-20
- Lead Sponsor
- Lynn Henry
- Target Recruit Count
- 2
- Registration Number
- NCT01921296
- Locations
- 🇺🇸
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
- Conditions
- Interventions
- First Posted Date
- 2012-04-30
- Last Posted Date
- 2018-07-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 323
- Registration Number
- NCT01587274
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Use of Cyclobenzaprine After Vaginal Surgery
- First Posted Date
- 2010-03-05
- Last Posted Date
- 2019-09-10
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 63
- Registration Number
- NCT01081990
- Locations
- 🇺🇸
Evanston NorthShore University HealthSystem, Evanston, Illinois, United States
Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters
- Conditions
- Interventions
- First Posted Date
- 2009-12-09
- Last Posted Date
- 2012-06-08
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 56
- Registration Number
- NCT01028014
- Locations
- 🇺🇸
University of Alabama at Birmingham, The Kirklin Clinic, Birmingham, Alabama, United States
Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2008-11-13
- Last Posted Date
- 2012-11-21
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 61
- Registration Number
- NCT00790270
- Locations
- 🇺🇸
Stony Brook University, Stony Brook, New York, United States
Drug Development Updates
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