Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Two Different Preparations of Sevoflurane in Induction

Phase 4

Completed

Conditions: Coughing on Induction
Vapors; Inhalation

Interventions: Drug: Sevoflurane

First Posted Date: 2013-02-15

Last Posted Date: 2013-04-19

Lead Sponsor: Istanbul University

Target Recruit Count: 200

Registration Number: NCT01792063

Locations: 🇹🇷
Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department, Istanbul, Fatih, Turkey

Three Anaesthesic Method in Electroconvulsive Theraphy

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Remifentanil and propofol
Drug: Sevoflurane

First Posted Date: 2013-01-03

Last Posted Date: 2013-01-03

Lead Sponsor: Inonu University

Target Recruit Count: 39

Registration Number: NCT01759589

Locations: 🇹🇷
Turgut Ozal Medical Center, Malatya, Turkey

Xenon in Off-pump Coronary Artery Bypass Graft Surgery

Phase 2

Completed

Conditions: Coronary Artery Disease
Anesthesia

Interventions: Drug: Xenon
Drug: sevoflurane

First Posted Date: 2012-12-28

Last Posted Date: 2014-03-26

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 42

Registration Number: NCT01757106

Locations: 🇧🇪
University Hospitals Leuven, Leuven, Belgium

Propofol Versus Sevoflurane Recovery After Gynecological Surgery

Phase 4

Completed

Conditions: Anesthesia
Surgery

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2012-12-24

Last Posted Date: 2016-03-14

Lead Sponsor: Northwestern University

Target Recruit Count: 90

Registration Number: NCT01755234

Locations: 🇺🇸
Prentice Women's Hospital, Chicago, Illinois, United States

Analysis of Cisatracurium Consumption in Balanced Anesthesia With 1% Sevoflurane, and With Only Sevoflurane, Using a Closed-loop Computer Controlled System Infusion.

Not Applicable

Completed

Conditions: Drug Interaction Potentiation

Interventions: Drug: Propofol
Drug: 1% Sevoflurane
Drug: Sevoflurane

First Posted Date: 2012-11-29

Last Posted Date: 2012-11-29

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 156

Registration Number: NCT01736371

Locations: 🇨🇳
Tianjin Medical University, Tianjin, China

Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG

Phase 4

Completed

Conditions: Middle Aged Patients
General Anesthesia

Interventions: Drug: Sevoflurane+Nitrous oxide
Drug: Sevoflurane

First Posted Date: 2012-10-12

Last Posted Date: 2014-02-04

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 76

Registration Number: NCT01705743

Locations: 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China